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Study · Animal study (in vivo) · rhesus macaque · 2007

13 results

The GLP-1 agonist exendin-4 reduces food intake in nonhuman primates through changes in meal size.

Scott KA, Moran TH

American journal of physiology. Regulatory, integrative and comparative physiology20 Jun 2007Cited by 90 (Europe PMC)

PMID17581835 (opens in a new tab)DOI10.1152/ajpregu.00323.2007 (opens in a new tab)PepBankPUB-17581835
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study13

13 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rhesus macaques, high-dose exendin‑4 completely prevented feeding during the feeding period.

    In plain wordsIn rhesus macaques, high-dose exendin‑4 completely prevented feeding during the observation period.

    Peptide
    Exenatide (exendin-4)
    Outcome
    DecreaseFood intake high dose
    Study

    rhesus macaquen = 4

    Adult male rhesus macaques
    Outcome group
    Appetite and food intake · Metabolic and weight
    Studied dose
    3.0 microg/kg · intramuscular · 6 hAs given in this study (rhesus macaque).

    Source sentences

    Summary
    Ex4 suppressed food intake in a dose-dependent manner, with the 3.0 microg/kg dose completely preventing feeding during the 6-h period and the 0.10 microg/kg dose suppressing intake by 17%.
    2 context sentences
    Summary · context
    In this study we investigated the effects of peripheral administration of Ex4 on food intake and meal patterns in adult male rhesus macaques.
    Summary · context
    Rhesus macaques (n = 4) that had been trained to lever press for food pellets were injected intramuscularly 15 min before the start of their 6-h daily feeding period.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rhesus macaques, low-dose exendin‑4 suppressed food intake.

    In plain wordsIn rhesus macaques, low-dose exendin‑4 reduced food intake.

    Peptide
    Exenatide (exendin-4)
    Outcome
    DecreaseFood intake low dose
    Study

    rhesus macaquen = 4

    Adult male rhesus macaques
    Outcome group
    Appetite and food intake · Metabolic and weight
    Studied dose
    0.10 microg/kg · intramuscular · 6 hAs given in this study (rhesus macaque).

    Measurements

    Intake suppression
    17%
    0.10 microg/kg

    Source sentences

    Summary
    Ex4 suppressed food intake in a dose-dependent manner, with the 3.0 microg/kg dose completely preventing feeding during the 6-h period and the 0.10 microg/kg dose suppressing intake by 17%.
    2 context sentences
    Summary · context
    In this study we investigated the effects of peripheral administration of Ex4 on food intake and meal patterns in adult male rhesus macaques.
    Summary · context
    Rhesus macaques (n = 4) that had been trained to lever press for food pellets were injected intramuscularly 15 min before the start of their 6-h daily feeding period.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In rhesus macaques, exendin‑4 reduced cumulative intake at every hourly measurement.

    In plain wordsIn rhesus macaques, exendin‑4 reduced cumulative food intake at every hourly measurement.

    Peptide
    Exenatide (exendin-4)
    Outcome
    DecreaseHourly cumulative intake low intermediate dose
    Study

    rhesus macaquen = 4

    Adult male rhesus macaques
    Outcome group
    Appetite and food intake · Metabolic and weight
    Studied dose
    0.32 microg/kg · intramuscular · 6 hAs given in this study (rhesus macaque).

    Source sentences

    Summary
    Doses of 0.32, 0.56, 1.0, and 3.0 microg/kg caused significant reductions in cumulative intake at all six hourly time points.
    2 context sentences
    Summary · context
    In this study we investigated the effects of peripheral administration of Ex4 on food intake and meal patterns in adult male rhesus macaques.
    Summary · context
    Rhesus macaques (n = 4) that had been trained to lever press for food pellets were injected intramuscularly 15 min before the start of their 6-h daily feeding period.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In rhesus macaques, exendin‑4 reduced cumulative intake at every hourly measurement.

    In plain wordsIn rhesus macaques, exendin‑4 reduced cumulative food intake at every hourly measurement.

    Peptide
    Exenatide (exendin-4)
    Outcome
    DecreaseHourly cumulative intake intermediate dose
    Study

    rhesus macaquen = 4

    Adult male rhesus macaques
    Outcome group
    Appetite and food intake · Metabolic and weight
    Studied dose
    0.56 microg/kg · intramuscular · 6 hAs given in this study (rhesus macaque).

    Source sentences

    Summary
    Doses of 0.32, 0.56, 1.0, and 3.0 microg/kg caused significant reductions in cumulative intake at all six hourly time points.
    2 context sentences
    Summary · context
    In this study we investigated the effects of peripheral administration of Ex4 on food intake and meal patterns in adult male rhesus macaques.
    Summary · context
    Rhesus macaques (n = 4) that had been trained to lever press for food pellets were injected intramuscularly 15 min before the start of their 6-h daily feeding period.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In rhesus macaques, exendin‑4 reduced cumulative intake at every hourly measurement.

    In plain wordsIn rhesus macaques, exendin‑4 reduced cumulative food intake at every hourly measurement.

    Peptide
    Exenatide (exendin-4)
    Outcome
    DecreaseHourly cumulative intake higher dose
    Study

    rhesus macaquen = 4

    Adult male rhesus macaques
    Outcome group
    Appetite and food intake · Metabolic and weight
    Studied dose
    1.0 microg/kg · intramuscular · 6 hAs given in this study (rhesus macaque).

    Source sentences

    Summary
    Doses of 0.32, 0.56, 1.0, and 3.0 microg/kg caused significant reductions in cumulative intake at all six hourly time points.
    2 context sentences
    Summary · context
    In this study we investigated the effects of peripheral administration of Ex4 on food intake and meal patterns in adult male rhesus macaques.
    Summary · context
    Rhesus macaques (n = 4) that had been trained to lever press for food pellets were injected intramuscularly 15 min before the start of their 6-h daily feeding period.
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In rhesus macaques, exendin‑4 reduced cumulative intake at every hourly measurement.

    In plain wordsIn rhesus macaques, exendin‑4 reduced cumulative food intake at every hourly measurement.

    Peptide
    Exenatide (exendin-4)
    Outcome
    DecreaseHourly cumulative intake highest dose
    Study

    rhesus macaquen = 4

    Adult male rhesus macaques
    Outcome group
    Appetite and food intake · Metabolic and weight
    Studied dose
    3.0 microg/kg · intramuscular · 6 hAs given in this study (rhesus macaque).

    Source sentences

    Summary
    Doses of 0.32, 0.56, 1.0, and 3.0 microg/kg caused significant reductions in cumulative intake at all six hourly time points.
    2 context sentences
    Summary · context
    In this study we investigated the effects of peripheral administration of Ex4 on food intake and meal patterns in adult male rhesus macaques.
    Summary · context
    Rhesus macaques (n = 4) that had been trained to lever press for food pellets were injected intramuscularly 15 min before the start of their 6-h daily feeding period.
  7. 07AnimalAnimal study (in vivo)Efficacy outcome

    In rhesus macaques, exendin‑4 significantly reduced meal size.

    In plain wordsIn rhesus macaques, exendin‑4 reduced meal size.

    Peptide
    Exenatide (exendin-4)
    Outcome
    DecreaseMeal size lower dose
    Study

    rhesus macaquen = 4

    Adult male rhesus macaques
    Outcome group
    Appetite and food intake · Metabolic and weight
    Studied dose
    0.32 microg/kg · intramuscularAs given in this study (rhesus macaque).

    Source sentences

    Summary
    Meal size was significantly reduced in a dose-dependent manner with significant reductions at the 0.32 and 1.0 microg/kg doses (P < 0.05).
    2 context sentences
    Summary · context
    In this study we investigated the effects of peripheral administration of Ex4 on food intake and meal patterns in adult male rhesus macaques.
    Summary · context
    Rhesus macaques (n = 4) that had been trained to lever press for food pellets were injected intramuscularly 15 min before the start of their 6-h daily feeding period.
  8. 08AnimalAnimal study (in vivo)Efficacy outcome

    In rhesus macaques, exendin‑4 significantly reduced meal size.

    In plain wordsIn rhesus macaques, exendin‑4 reduced meal size.

    Peptide
    Exenatide (exendin-4)
    Outcome
    DecreaseMeal size higher dose
    Study

    rhesus macaquen = 4

    Adult male rhesus macaques
    Outcome group
    Appetite and food intake · Metabolic and weight
    Studied dose
    1.0 microg/kg · intramuscularAs given in this study (rhesus macaque).

    Source sentences

    Summary
    Meal size was significantly reduced in a dose-dependent manner with significant reductions at the 0.32 and 1.0 microg/kg doses (P < 0.05).
    2 context sentences
    Summary · context
    In this study we investigated the effects of peripheral administration of Ex4 on food intake and meal patterns in adult male rhesus macaques.
    Summary · context
    Rhesus macaques (n = 4) that had been trained to lever press for food pellets were injected intramuscularly 15 min before the start of their 6-h daily feeding period.
  9. 09AnimalAnimal study (in vivo)Efficacy outcome

    In rhesus macaques, food intake returned to baseline without compensatory feeding after exendin‑4.

    In plain wordsIn rhesus macaques, food intake returned to baseline without extra feeding after exendin‑4.

    Peptide
    Exenatide (exendin-4)
    Outcome
    No significant changePost-dose food intake
    Study

    rhesus macaquen = 4

    Adult male rhesus macaques
    Comparator
    Baseline
    Outcome group
    Appetite and food intake · Metabolic and weight
    Studied dose
    Dose not stated · intramuscular · Day 2 and 3As given in this study (rhesus macaque).

    Source sentences

    Summary
    Day 2 and 3 intakes returned to baseline levels with no compensation for Ex4-induced feeding suppression.
    2 context sentences
    Summary · context
    In this study we investigated the effects of peripheral administration of Ex4 on food intake and meal patterns in adult male rhesus macaques.
    Summary · context
    Rhesus macaques (n = 4) that had been trained to lever press for food pellets were injected intramuscularly 15 min before the start of their 6-h daily feeding period.
  10. 10AnimalAnimal study (in vivo)Efficacy outcome

    In rhesus macaques, repeated exendin‑4 sustained intake reductions without compensation.

    In plain wordsIn rhesus macaques, repeated exendin‑4 reduced food intake without compensatory feeding.

    Peptide
    Exenatide (exendin-4)
    Outcome
    DecreaseRepeated-dose intake lower dose
    Study

    rhesus macaquen = 4

    Adult male rhesus macaques
    Outcome group
    Appetite and food intake · Metabolic and weight
    Studied dose
    0.32 microg/kg · intramuscular · 5 consecutive daysAs given in this study (rhesus macaque).

    Source sentences

    Summary
    Administration of doses of 0.32 and 0.56 microg/kg Ex4 over 5 consecutive days led to sustained reductions in intake with no evidence of compensation.
    2 context sentences
    Summary · context
    In this study we investigated the effects of peripheral administration of Ex4 on food intake and meal patterns in adult male rhesus macaques.
    Summary · context
    Rhesus macaques (n = 4) that had been trained to lever press for food pellets were injected intramuscularly 15 min before the start of their 6-h daily feeding period.
  11. 11AnimalAnimal study (in vivo)Efficacy outcome

    In rhesus macaques, repeated exendin‑4 sustained intake reductions without compensation.

    In plain wordsIn rhesus macaques, repeated exendin‑4 reduced food intake without compensatory feeding.

    Peptide
    Exenatide (exendin-4)
    Outcome
    DecreaseRepeated-dose intake higher dose
    Study

    rhesus macaquen = 4

    Adult male rhesus macaques
    Outcome group
    Appetite and food intake · Metabolic and weight
    Studied dose
    0.56 microg/kg · intramuscular · 5 consecutive daysAs given in this study (rhesus macaque).

    Source sentences

    Summary
    Administration of doses of 0.32 and 0.56 microg/kg Ex4 over 5 consecutive days led to sustained reductions in intake with no evidence of compensation.
    2 context sentences
    Summary · context
    In this study we investigated the effects of peripheral administration of Ex4 on food intake and meal patterns in adult male rhesus macaques.
    Summary · context
    Rhesus macaques (n = 4) that had been trained to lever press for food pellets were injected intramuscularly 15 min before the start of their 6-h daily feeding period.
  12. 12AnimalAnimal study (in vivo)Efficacy outcome

    In rhesus macaques, repeated exendin‑4 reduced intake through effects on meal size.

    In plain wordsIn rhesus macaques, repeated exendin‑4 reduced food intake through smaller meals.

    Peptide
    Exenatide (exendin-4)
    Outcome
    DecreaseRepeated-dose meal size lower dose
    Study

    rhesus macaquen = 4

    Adult male rhesus macaques
    Outcome group
    Appetite and food intake · Metabolic and weight
    Studied dose
    0.32 microg/kg · intramuscular · 5 consecutive daysAs given in this study (rhesus macaque).

    Source sentences

    Summary
    Again, these reductions were due to specific effects on meal size.
    3 context sentences
    Summary · context
    Administration of doses of 0.32 and 0.56 microg/kg Ex4 over 5 consecutive days led to sustained reductions in intake with no evidence of compensation.
    Summary · context
    In this study we investigated the effects of peripheral administration of Ex4 on food intake and meal patterns in adult male rhesus macaques.
    Summary · context
    Rhesus macaques (n = 4) that had been trained to lever press for food pellets were injected intramuscularly 15 min before the start of their 6-h daily feeding period.
  13. 13AnimalAnimal study (in vivo)Efficacy outcome

    In rhesus macaques, repeated exendin‑4 reduced intake through effects on meal size.

    In plain wordsIn rhesus macaques, repeated exendin‑4 reduced food intake through smaller meals.

    Peptide
    Exenatide (exendin-4)
    Outcome
    DecreaseRepeated-dose meal size higher dose
    Study

    rhesus macaquen = 4

    Adult male rhesus macaques
    Outcome group
    Appetite and food intake · Metabolic and weight
    Studied dose
    0.56 microg/kg · intramuscular · 5 consecutive daysAs given in this study (rhesus macaque).

    Source sentences

    Summary
    Again, these reductions were due to specific effects on meal size.
    3 context sentences
    Summary · context
    Administration of doses of 0.32 and 0.56 microg/kg Ex4 over 5 consecutive days led to sustained reductions in intake with no evidence of compensation.
    Summary · context
    In this study we investigated the effects of peripheral administration of Ex4 on food intake and meal patterns in adult male rhesus macaques.
    Summary · context
    Rhesus macaques (n = 4) that had been trained to lever press for food pellets were injected intramuscularly 15 min before the start of their 6-h daily feeding period.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    22 Oct 2026, 02:26 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 18:59 UTC

    First added · source update from Europe PMC

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