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Study · In vitro (cells) · 2007

4 results

Subcellular distribution of thymosin beta4.

Zoubek RE, Hannappel E

Annals of the New York Academy of Sciences13 Jun 2007Cited by 15 (Europe PMC)

PMID17567947 (opens in a new tab)DOI10.1196/annals.1415.031 (opens in a new tab)PepBankPUB-17567947
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Mechanism

    In cytoplasm-depleted A431 cells, no thymosin beta‑4 variant or fragment passed the intact nuclear pore, so all were excluded from the nucleus.

    In plain wordsIn cells, none of the thymosin beta‑4 variants or fragments crossed the nuclear pore of cytoplasm-depleted cells.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    Not applicableNuclear entry in cytoplasm-depleted cells
    Study

    humann: not reported in source

    A431 cells
    Outcome group
    Receptor activity and mechanism · Pharmacology
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In contrast to Oregon Green cadaverine, none of the variants or fragments of thymosin beta(4) could pass the intact nuclear pore of cytoplasm-depleted cells and were hence excluded from the nucleus.
    1 context sentence
    Summary · context
    The localization of Oregon Green cadaverine-labeled thymosin beta(4), its fragments, and variants was investigated in cytoplasm-depleted A431 cells and in microinjected cells without and with fixation.
  2. 02LabIn vitro (cells)Mechanism

    In living A431 cells, all thymosin beta‑4 variants were equally distributed.

    In plain wordsIn cells, all thymosin beta‑4 variants spread equally in living cells.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    Not applicableDistribution of variants in living cells
    Study

    humann: not reported in source

    A431 cells
    Outcome group
    Receptor activity and mechanism · Pharmacology
    Studied dose
    Dose not stated

    Source sentences

    Summary
    However, an equal distribution of all thymosin beta(4) variants was observed in living cells.
    1 context sentence
    Summary · context
    The localization of Oregon Green cadaverine-labeled thymosin beta(4), its fragments, and variants was investigated in cytoplasm-depleted A431 cells and in microinjected cells without and with fixation.
  3. 03LabIn vitro (cells)Mechanism

    In A431 cells, nuclear localization of thymosin beta‑4 did not depend on its actin-binding ability or its basic lysine cluster.

    In plain wordsIn cells, thymosin beta‑4 reached the nucleus without needing its actin-binding site or its lysine cluster.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    No significant changeDependence of nuclear localization on actin binding and lysine cluster
    Study

    humann: not reported in source

    A431 cells
    Outcome group
    Receptor activity and mechanism · Pharmacology
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The nuclear localization is neither dependent on the actin-binding ability of thymosin beta(4) nor on its basic lysine cluster.
    1 context sentence
    Summary · context
    The localization of Oregon Green cadaverine-labeled thymosin beta(4), its fragments, and variants was investigated in cytoplasm-depleted A431 cells and in microinjected cells without and with fixation.
  4. 04LabIn vitro (cells)Mechanism

    In A431 cells, thymosin beta‑4 fragments 1-26 and 27-43 entered the nucleus of intact cells after injection but were excluded from cytoplasm-depleted nuclei.

    In plain wordsIn cells, thymosin beta‑4 fragments entered the nucleus of intact cells but not of cytoplasm-depleted cells.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    Not applicableNuclear entry of fragments 1-26 and 27-43
    Study

    humann: not reported in source

    A431 cells
    Outcome group
    Receptor activity and mechanism · Pharmacology
    Studied dose
    Dose not stated

    Source sentences

    Summary
    the ability of the fragments thymosin beta(4)(1-26) and beta(4)(27-43) to enter the nucleus in intact cells immediately after injection, and their exclusion from cytoplasm-depleted nuclei
    1 context sentence
    Summary · context
    The localization of Oregon Green cadaverine-labeled thymosin beta(4), its fragments, and variants was investigated in cytoplasm-depleted A431 cells and in microinjected cells without and with fixation.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 01:52 UTC

    Study results updated

  2. Version 1

    12 Oct 2026, 18:17 UTC

    First added · source update from Europe PMC

Subjects

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Publication types

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