Skip to content

Study · In vitro (cells) · 2007

7 results

Localization of thymosin beta-4 in tumors.

Larsson LI, Holck S

Annals of the New York Academy of Sciences10 May 2007Cited by 12 (Europe PMC)

PMID17495241 (opens in a new tab)DOI10.1196/annals.1415.005 (opens in a new tab)PepBankPUB-17495241
Publisher pagePubMedAsk about this study
Jump to 7 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

1 result from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Efficacy outcome

    Treatment of cultured SK-BR-3 breast cancer cells with 1-4 microg Tbeta4/mL significantly increased cell numbers.

    In plain wordsIn cultured human breast cancer cells, thymosin beta‑4 increased the number of cells.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseSK-BR-3 breast cancer cell number
    Study

    humann: not reported in source

    cultured SK-BR-3 breast cancer cells, MTT assay
    Outcome group
    Tumor growth · Cancer
    Studied dose
    1-4 microg/mLAs given in this study (human).

    Source sentences

    Summary
    Treatment of cultured breast cancer cells (SK-BR-3) with 1-4 microg thymosin beta-4/mL significantly increased cell numbers, as determined by MTT-assays.

Natural levels measured6

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 02HumanEndogenous levelObservational studyMechanism

    In human breast cancers, immunofluorescence showed a very heterogeneous staining pattern for Tbeta4.

    In plain wordsIn human breast cancer tissue, the body's own thymosin beta‑4 showed a very uneven staining pattern.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    Not applicableTbeta4 staining pattern in breast cancers
    Study

    n: not reported in source

    breast cancer tissue, immunofluorescence
    Outcome group
    Tumor growth · Cancer

    Source sentences

    Summary
    A very heterogeneous staining pattern for thymosin beta-4 was observed.
    1 context sentence
    Summary · context
    We therefore examined breast cancers for thymosin beta-4 using immunofluorescence.

    This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.

  2. 03HumanEndogenous levelObservational studyMechanism

    In breast cancers, leukocytes and macrophages showed intense Tbeta4 reactivity, while cancer cells and endothelial cells showed more variable reactivity.

    In plain wordsIn human breast cancer tissue, immune cells showed strong staining for the body's own thymosin beta‑4. Cancer cells and vessel cells varied more.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    Not applicableTbeta4 staining by cell type
    Study

    n: not reported in source

    breast cancer tissue, immunofluorescence
    Outcome group
    Tumor growth · Cancer

    Source sentences

    Summary
    Thus, while leukocytes and macrophages showed intense reactivity for this polypeptide, cancer cells, and endothelial cells showed a much more variable reactivity.
    1 context sentence
    Summary · context
    We therefore examined breast cancers for thymosin beta-4 using immunofluorescence.

    This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.

  3. 04HumanEndogenous levelObservational studyMechanism

    Colorectal carcinomas showed similar heterogeneous Tbeta4 staining.

    In plain wordsIn human colon cancer tissue, the body's own thymosin beta‑4 showed a similar uneven staining pattern.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    Not applicableTbeta4 staining pattern in colorectal carcinomas
    Study

    n: not reported in source

    colorectal carcinoma tissue
    Outcome group
    Tumor growth · Cancer

    Source sentences

    Summary
    A similar heterogeneous staining was observed also in colorectal carcinomas.

    This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.

  4. 05HumanEndogenous levelObservational studyMechanism

    In breast cancers, Tbeta4 staining of cancer cells did not correlate with histological grade.

    In plain wordsIn human breast cancer tissue, staining for the body's own thymosin beta‑4 was not linked to tumor grade.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    No significant changeCorrelation of cancer cell Tbeta4 staining with histological grade
    Study

    n: not reported in source

    breast cancer tissue
    Outcome group
    Tumor growth · Cancer

    Source sentences

    Summary
    The degree of staining of breast cancer cells for thymosin beta-4 correlated neither to histological grade nor to endothelial cell staining.
    1 context sentence
    Summary · context
    We therefore examined breast cancers for thymosin beta-4 using immunofluorescence.

    This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.

  5. 06HumanEndogenous levelObservational studyMechanism

    In breast cancers, Tbeta4 staining of cancer cells did not correlate with Tbeta4 staining of endothelial cells.

    In plain wordsIn human breast cancer tissue, staining for the body's own thymosin beta‑4 in cancer cells was not linked to staining in vessel cells.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    No significant changeCorrelation of cancer cell Tbeta4 staining with endothelial cell staining
    Study

    n: not reported in source

    breast cancer tissue
    Outcome group
    Tumor growth · Cancer

    Source sentences

    Summary
    The degree of staining of breast cancer cells for thymosin beta-4 correlated neither to histological grade nor to endothelial cell staining.
    1 context sentence
    Summary · context
    We therefore examined breast cancers for thymosin beta-4 using immunofluorescence.

    This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.

  6. 07HumanEndogenous levelObservational studyMechanism

    In breast cancers, endothelial cell Tbeta4 staining showed only a tendency toward correlation with histological grade (P = 0.07).

    In plain wordsIn human breast cancer tissue, staining for the body's own thymosin beta‑4 in vessel cells showed only a weak, not significant, link to tumor grade.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    No significant changeCorrelation of endothelial Tbeta4 staining with histological grade
    Study

    n: not reported in source

    breast cancer tissue
    Outcome group
    Tumor growth · Cancer

    Measurements

    P value
    0.07
    endothelial staining vs histological grade

    Source sentences

    Summary
    However, there was a tendency toward correlation (P = 0.07) between staining of endothelial cells and histological grade.
    1 context sentence
    Summary · context
    We therefore examined breast cancers for thymosin beta-4 using immunofluorescence.

    This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 01:52 UTC

    Study results updated

  2. Version 1

    12 Oct 2026, 18:17 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.