Low-dose pramlintide reduced food intake and meal duration in healthy, normal-weight subjects.

Chapman I, Parker B, Doran S, Feinle-Bisset C, Wishart J, Lush CW, Chen K, Lacerte C, Burns C, McKay R, Weyer C, Horowitz M

Obesity (Silver Spring, Md.)1 May 2007Cited by 45 (Europe PMC)

PMID17495194DOI10.1038/oby.2007.626PepBankPUB-17495194

Publisher page PubMedAsk about this study

Jump to 11 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study11

11 results from studies that gave the peptide. 11 results from people.

01HumanRandomized controlled trialEfficacy outcome
In healthy normal-weight men, pramlintide reduced buffet caloric intake versus placebo.
In plain wordsIn healthy normal-weight men, pramlintide reduced calories eaten at a buffet compared with placebo.
Peptide
Pramlintide (Symlin)
Outcome
DecreaseTotal caloric intake
Study
n = 15
Comparator
Placebo
Outcome group
Appetite and food intake · Metabolic and weight
Studied dose
30 microg · subcutaneous · Single injectionAs given in this study (human).
Measurements
Total caloric intake
1411 kcal
placebo
Total caloric intake
1190 kcal
pramlintide
Caloric intake difference
−221 kcal
pramlintide versus placebo
Caloric intake difference
−14%
pramlintide versus placebo
Source sentences
Summary
Compared with placebo, pramlintide reduced total caloric intake (1411 +/- 94 vs. 1190 +/- 117 kcal; Delta, -221 +/- 101 kcal; -14 +/- 9%; p = 0.05) and meal duration (36 +/- 2 vs. 31 +/- 3 minutes; Delta, -5.1 +/- 1.4 minutes; p < 0.005).
2 context sentences(design, population, supporting numbers)
Summary · context
In a randomized, double-blind, placebo-controlled, cross-over study, 15 healthy men (age, 24 +/- 7 years; BMI, 22.2 +/- 1.8 kg/m(2)) underwent a standardized buffet meal test on two occasions.
Summary · context
After an overnight fast, subjects received a single subcutaneous injection of pramlintide (30 microg) or placebo, followed immediately by a standardized pre-load meal.
Report a problemFND-1749519401
02HumanRandomized controlled trialEfficacy outcome
In healthy normal-weight men, pramlintide reduced buffet meal duration versus placebo.
In plain wordsIn healthy normal-weight men, buffet meals were shorter with pramlintide than placebo.
Peptide
Pramlintide (Symlin)
Outcome
DecreaseMeal duration
Study
n = 15
Comparator
Placebo
Outcome group
Appetite and food intake · Metabolic and weight
Studied dose
30 microg · subcutaneous · Single injectionAs given in this study (human).
Measurements
Meal duration
36 minutes
placebo
Meal duration
31 minutes
pramlintide
Meal duration difference
−5.1 minutes
pramlintide versus placebo
Source sentences
Summary
Compared with placebo, pramlintide reduced total caloric intake (1411 +/- 94 vs. 1190 +/- 117 kcal; Delta, -221 +/- 101 kcal; -14 +/- 9%; p = 0.05) and meal duration (36 +/- 2 vs. 31 +/- 3 minutes; Delta, -5.1 +/- 1.4 minutes; p < 0.005).
2 context sentences(design, population, supporting numbers)
Summary · context
In a randomized, double-blind, placebo-controlled, cross-over study, 15 healthy men (age, 24 +/- 7 years; BMI, 22.2 +/- 1.8 kg/m(2)) underwent a standardized buffet meal test on two occasions.
Summary · context
After an overnight fast, subjects received a single subcutaneous injection of pramlintide (30 microg) or placebo, followed immediately by a standardized pre-load meal.
Report a problemFND-1749519402
03HumanRandomized controlled trialEfficacy outcome
In healthy normal-weight men, hunger ratings trended lower during the first hour after pramlintide than placebo.
In plain wordsIn healthy normal-weight men, hunger tended to be lower during the first hour after pramlintide than placebo.
Peptide
Pramlintide (Symlin)
Outcome
DecreaseHunger during first hour
Study
n = 15
Comparator
Placebo
Outcome group
Appetite and food intake · Metabolic and weight
Studied dose
30 microg · subcutaneous · Single injectionAs given in this study (human).
Source sentences
Summary
Visual analog scale profiles of hunger trended lower and fullness higher during the first hour after pramlintide administration.
2 context sentences(design, population, supporting numbers)
Summary · context
In a randomized, double-blind, placebo-controlled, cross-over study, 15 healthy men (age, 24 +/- 7 years; BMI, 22.2 +/- 1.8 kg/m(2)) underwent a standardized buffet meal test on two occasions.
Summary · context
After an overnight fast, subjects received a single subcutaneous injection of pramlintide (30 microg) or placebo, followed immediately by a standardized pre-load meal.
Report a problemFND-1749519403
04HumanRandomized controlled trialEfficacy outcome
In healthy normal-weight men, fullness ratings trended higher during the first hour after pramlintide than placebo.
In plain wordsIn healthy normal-weight men, fullness tended to be higher during the first hour after pramlintide than placebo.
Peptide
Pramlintide (Symlin)
Outcome
IncreaseFullness during first hour
Study
n = 15
Comparator
Placebo
Outcome group
Appetite and food intake · Metabolic and weight
Studied dose
30 microg · subcutaneous · Single injectionAs given in this study (human).
Source sentences
Summary
Visual analog scale profiles of hunger trended lower and fullness higher during the first hour after pramlintide administration.
2 context sentences(design, population, supporting numbers)
Summary · context
In a randomized, double-blind, placebo-controlled, cross-over study, 15 healthy men (age, 24 +/- 7 years; BMI, 22.2 +/- 1.8 kg/m(2)) underwent a standardized buffet meal test on two occasions.
Summary · context
After an overnight fast, subjects received a single subcutaneous injection of pramlintide (30 microg) or placebo, followed immediately by a standardized pre-load meal.
Report a problemFND-1749519404
05HumanRandomized controlled trialEfficacy outcome
In healthy normal-weight men, hunger changed similarly after the buffet with pramlintide and placebo despite lower intake with pramlintide.
In plain wordsIn healthy normal-weight men, hunger changed similarly after the buffet with pramlintide and placebo.
Peptide
Pramlintide (Symlin)
Outcome
No significant changeHunger response to buffet
Study
n = 15
Comparator
Placebo
Outcome group
Appetite and food intake · Metabolic and weight
Studied dose
30 microg · subcutaneous · Single injectionAs given in this study (human).
Source sentences
Summary
In response to the buffet, hunger and fullness changed to a similar degree after pramlintide and placebo, despite subjects on pramlintide consuming 14% fewer kilocalories.
2 context sentences(design, population, supporting numbers)
Summary · context
In a randomized, double-blind, placebo-controlled, cross-over study, 15 healthy men (age, 24 +/- 7 years; BMI, 22.2 +/- 1.8 kg/m(2)) underwent a standardized buffet meal test on two occasions.
Summary · context
After an overnight fast, subjects received a single subcutaneous injection of pramlintide (30 microg) or placebo, followed immediately by a standardized pre-load meal.
Report a problemFND-1749519405
06HumanRandomized controlled trialEfficacy outcome
In healthy normal-weight men, fullness changed similarly after the buffet with pramlintide and placebo despite lower intake with pramlintide.
In plain wordsIn healthy normal-weight men, fullness changed similarly after the buffet with pramlintide and placebo.
Peptide
Pramlintide (Symlin)
Outcome
No significant changeFullness response to buffet
Study
n = 15
Comparator
Placebo
Outcome group
Appetite and food intake · Metabolic and weight
Studied dose
30 microg · subcutaneous · Single injectionAs given in this study (human).
Source sentences
Summary
In response to the buffet, hunger and fullness changed to a similar degree after pramlintide and placebo, despite subjects on pramlintide consuming 14% fewer kilocalories.
2 context sentences(design, population, supporting numbers)
Summary · context
In a randomized, double-blind, placebo-controlled, cross-over study, 15 healthy men (age, 24 +/- 7 years; BMI, 22.2 +/- 1.8 kg/m(2)) underwent a standardized buffet meal test on two occasions.
Summary · context
After an overnight fast, subjects received a single subcutaneous injection of pramlintide (30 microg) or placebo, followed immediately by a standardized pre-load meal.
Report a problemFND-1749519406
07HumanRandomized controlled trialSafety outcome
In healthy normal-weight men, nausea ratings remained near baseline and did not differ between pramlintide and placebo.
In plain wordsIn healthy normal-weight men, nausea ratings stayed near baseline and were similar with pramlintide and placebo.
Peptide
Pramlintide (Symlin)
Outcome
No significant changeNausea ratings
Study
n = 15
Comparator
Placebo
Outcome group
Gastrointestinal adverse events · Gastrointestinal
Studied dose
30 microg · subcutaneous · Single injectionAs given in this study (human).
Source sentences
Summary
Visual analog scale nausea ratings remained near baseline, without differences between treatments.
2 context sentences(design, population, supporting numbers)
Summary · context
In a randomized, double-blind, placebo-controlled, cross-over study, 15 healthy men (age, 24 +/- 7 years; BMI, 22.2 +/- 1.8 kg/m(2)) underwent a standardized buffet meal test on two occasions.
Summary · context
After an overnight fast, subjects received a single subcutaneous injection of pramlintide (30 microg) or placebo, followed immediately by a standardized pre-load meal.
Report a problemFND-1749519407
08HumanRandomized controlled trialMechanism
In healthy normal-weight men, plasma peptide YY did not differ between pramlintide and placebo.
In plain wordsIn healthy normal-weight men, peptide YY blood levels were similar with pramlintide and placebo.
Peptide
Pramlintide (Symlin)
Outcome
No significant changePlasma peptide YY
Study
n = 15
Comparator
Placebo
Outcome group
Appetite and food intake · Endocrine and hormones
Studied dose
30 microg · subcutaneous · Single injectionAs given in this study (human).
Source sentences
Summary
Plasma peptide YY, cholecystokinin, and ghrelin concentrations did not differ with treatment, whereas glucagon-like peptide-1 concentrations after meals were lower in response to pramlintide than to placebo.
2 context sentences(design, population, supporting numbers)
Summary · context
In a randomized, double-blind, placebo-controlled, cross-over study, 15 healthy men (age, 24 +/- 7 years; BMI, 22.2 +/- 1.8 kg/m(2)) underwent a standardized buffet meal test on two occasions.
Summary · context
After an overnight fast, subjects received a single subcutaneous injection of pramlintide (30 microg) or placebo, followed immediately by a standardized pre-load meal.
Report a problemFND-1749519408
09HumanRandomized controlled trialMechanism
In healthy normal-weight men, plasma cholecystokinin did not differ between pramlintide and placebo.
In plain wordsIn healthy normal-weight men, cholecystokinin blood levels were similar with pramlintide and placebo.
Peptide
Pramlintide (Symlin)
Outcome
No significant changePlasma cholecystokinin
Study
n = 15
Comparator
Placebo
Outcome group
Appetite and food intake · Endocrine and hormones
Studied dose
30 microg · subcutaneous · Single injectionAs given in this study (human).
Source sentences
Summary
Plasma peptide YY, cholecystokinin, and ghrelin concentrations did not differ with treatment, whereas glucagon-like peptide-1 concentrations after meals were lower in response to pramlintide than to placebo.
2 context sentences(design, population, supporting numbers)
Summary · context
In a randomized, double-blind, placebo-controlled, cross-over study, 15 healthy men (age, 24 +/- 7 years; BMI, 22.2 +/- 1.8 kg/m(2)) underwent a standardized buffet meal test on two occasions.
Summary · context
After an overnight fast, subjects received a single subcutaneous injection of pramlintide (30 microg) or placebo, followed immediately by a standardized pre-load meal.
Report a problemFND-1749519409
10HumanRandomized controlled trialMechanism
In healthy normal-weight men, plasma ghrelin did not differ between pramlintide and placebo.
In plain wordsIn healthy normal-weight men, ghrelin blood levels were similar with pramlintide and placebo.
Peptide
Pramlintide (Symlin)
Outcome
No significant changePlasma ghrelin
Study
n = 15
Comparator
Placebo
Outcome group
Appetite and food intake · Endocrine and hormones
Studied dose
30 microg · subcutaneous · Single injectionAs given in this study (human).
Source sentences
Summary
Plasma peptide YY, cholecystokinin, and ghrelin concentrations did not differ with treatment, whereas glucagon-like peptide-1 concentrations after meals were lower in response to pramlintide than to placebo.
2 context sentences(design, population, supporting numbers)
Summary · context
In a randomized, double-blind, placebo-controlled, cross-over study, 15 healthy men (age, 24 +/- 7 years; BMI, 22.2 +/- 1.8 kg/m(2)) underwent a standardized buffet meal test on two occasions.
Summary · context
After an overnight fast, subjects received a single subcutaneous injection of pramlintide (30 microg) or placebo, followed immediately by a standardized pre-load meal.
Report a problemFND-1749519410
11HumanRandomized controlled trialMechanism
In healthy normal-weight men, post-meal glucagon-like peptide-1 concentrations were lower with pramlintide than placebo.
In plain wordsIn healthy normal-weight men, blood glucagon-like peptide-1 after meals was lower with pramlintide than placebo.
Peptide
Pramlintide (Symlin)
Outcome
DecreasePost-meal glucagon-like peptide-1
Study
n = 15
Comparator
Placebo
Outcome group
Appetite and food intake · Endocrine and hormones
Studied dose
30 microg · subcutaneous · Single injectionAs given in this study (human).
Source sentences
Summary
Plasma peptide YY, cholecystokinin, and ghrelin concentrations did not differ with treatment, whereas glucagon-like peptide-1 concentrations after meals were lower in response to pramlintide than to placebo.
2 context sentences(design, population, supporting numbers)
Summary · context
In a randomized, double-blind, placebo-controlled, cross-over study, 15 healthy men (age, 24 +/- 7 years; BMI, 22.2 +/- 1.8 kg/m(2)) underwent a standardized buffet meal test on two occasions.
Summary · context
After an overnight fast, subjects received a single subcutaneous injection of pramlintide (30 microg) or placebo, followed immediately by a standardized pre-load meal.
Report a problemFND-1749519411

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
22 Oct 2026, 02:26 UTC
Study results updated
Version 1
21 Oct 2026, 18:59 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.