In healthy males during a hyperinsulinaemic clamp, pegvisomant did not significantly alter total ghrelin compared with saline control.
In plain wordsIn healthy males during an insulin clamp, pegvisomant did not significantly change ghrelin compared with saline control.
- Peptide
- Pegvisomant
- Outcome
- No significant changeTotal ghrelin levels
- Study
n = 8
- Comparator
- Saline control
- Outcome group
- Growth hormone and IGF-1 · Endocrine and hormones
- Studied dose
- 30 mg · subcutaneousAs given in this study (human).
Source sentences
Neither GH administration nor GHR blockade resulted in significant alterations in total ghrelin levels in the presence of unaltered insulin and FFA levels.
1 context sentence(design, population, supporting numbers)
In a randomized design, eight healthy males each underwent an 8-h hyperinsulinaemic glucose clamp on four occasions together with either: (1) control (saline), (2) intravenous FFA infusion (intralipid/heparin infusion 4 h), (3) a GH bolus (0.5 mg i.v.) or (4) GHR blockade (pegvisomant, 30 mg s.c.).