In hypogonadal mice given a GnRH gene vector, kisspeptin‑10 challenge raised plasma LH, which supported regulation of the introduced GnRH transgene.
In plain wordsIn mice given a GnRH gene treatment, kisspeptin‑10 was used as a test and LH rose, which supported regulation of the new gene.
- Peptide
- Kisspeptin-10
- Outcome
- IncreasePlasma LH after kisspeptin-10 in GnRH-vector-treated hpg mice
- Study
mousen: not reported in source
Hypogonadal (hpg) female mice- Outcome group
- Sex hormones and fertility · Reproductive and sexual health
Source sentences
Administration of kisspeptin-10 resulted in an increase in plasma luteinizing hormone levels, further supporting appropriate regulation of the introduced GnRH transgene.
1 context sentence(design, population, supporting numbers)
Here we show an improvement in reproductive parameters of adult female homozygous hpg mice by direct infusion into the hypothalamic preoptic area (POA) of a herpes simplex virus (HSV)-based amplicon vector containing a 13.5 kb genomic fragment encoding the GnRH gene together with its cognate promote…
In this study, Kisspeptin-10 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Kisspeptin-10.