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Study · Not a test of the peptide alone · 2007

3 results

Contributions from all over: widely distributed residues in thymosin beta-4 affect the kinetics and stability of actin binding.

Au JK, De La Cruz EM, Safer D

Annals of the New York Academy of Sciences27 Apr 2007Cited by 1 (Europe PMC)

PMID17468230 (opens in a new tab)DOI10.1196/annals.1415.015 (opens in a new tab)PepBankPUB-17468230
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone3

In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Thymosin beta-4 (human).

  1. 01LabNot a test of Thymosin beta-4 (human) aloneIn vitro (cell-free)Activity measurement

    Alanine substitutions at Pro4, Lys18, Lys19, Pro27, Leu28, Pro29 and Ile34 of Tbeta4 weakened the affinity of the actin-Tbeta4 complex.

    In plain wordsIn lab tests, changing single amino acids in thymosin beta‑4 weakened how tightly it bound actin.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    DecreaseActin binding affinity of Tbeta4 alanine mutants
    Study

    n: not reported in source

    purified MgATP-actin monomers with Tbeta4 mutants
    Comparator
    Wild-type Tbeta4
    Outcome group
    Receptor activity and mechanism · Pharmacology

    Source sentences

    Summary
    All these mutations weaken the affinity of the actin-Tbeta4 complex
    2 context sentences
    Summary · context
    Pro4, Lys18, Lys19, Pro27, Leu28, Pro29, and Ile34 were substituted by alanine residues.
    Summary · context
    We have used site-directed mutagenesis to investigate the contributions of widely distributed residues in the thymosin beta-4 (Tbeta4) sequence to the formation and stability of the actin-Tbeta4 complex.

    In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).

  2. 02LabNot a test of Thymosin beta-4 (human) aloneIn vitro (cell-free)Activity measurement

    Several Tbeta4 mutants, particularly at proline residues, dissociated from actin much more rapidly than the wild-type complex.

    In plain wordsIn lab tests, several changed versions of thymosin beta‑4 let go of actin much faster than the original.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseDissociation rate of actin-Tbeta4 complex for mutants
    Study

    n: not reported in source

    purified MgATP-actin monomers with Tbeta4 mutants
    Comparator
    Wild-type Tbeta4
    Outcome group
    Receptor activity and mechanism · Pharmacology

    Source sentences

    Summary
    Several mutants, particularly at proline residues, dissociate much more rapidly than the wild-type complex
    1 context sentence
    Summary · context
    We have used site-directed mutagenesis to investigate the contributions of widely distributed residues in the thymosin beta-4 (Tbeta4) sequence to the formation and stability of the actin-Tbeta4 complex.

    In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).

  3. 03LabNot a test of Thymosin beta-4 (human) aloneIn vitro (cell-free)Activity measurement

    Several Tbeta4 mutants showed small increases in the rate of association with actin.

    In plain wordsIn lab tests, several changed versions of thymosin beta‑4 attached to actin slightly faster than the original.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseAssociation rate of actin-Tbeta4 complex for mutants
    Study

    n: not reported in source

    purified MgATP-actin monomers with Tbeta4 mutants
    Comparator
    Wild-type Tbeta4
    Outcome group
    Receptor activity and mechanism · Pharmacology

    Source sentences

    Summary
    but also show small increases in the rate of association.
    1 context sentence
    Summary · context
    We have used site-directed mutagenesis to investigate the contributions of widely distributed residues in the thymosin beta-4 (Tbeta4) sequence to the formation and stability of the actin-Tbeta4 complex.

    In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 01:52 UTC

    Study results updated

  2. Version 1

    12 Oct 2026, 18:17 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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