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Study · Animal study (in vivo) · rhesus monkey · 2007

7 results

Effect of continuous intravenous administration of human metastin 45-54 on the neuroendocrine activity of the hypothalamic-pituitary-testicular axis in the adult male rhesus monkey (Macaca mulatta).

Ramaswamy S, Seminara SB, Pohl CR, DiPietro MJ, Crowley WF Jr, Plant TM

Endocrinology5 Apr 2007Cited by 103 (Europe PMC)

PMID17412800 (opens in a new tab)DOI10.1210/en.2007-0207 (opens in a new tab)PepBankPUB-17412800
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

7 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In adult male rhesus monkeys, continuous iv infusion of human metastin 45-54 (200 or 400 microg/h) raised circulating LH, which peaked 2-3 h after the start.

    In plain wordsIn adult male monkeys, a steady infusion of metastin 45-54 first raised LH clearly, peaking after 2 to 3 hours.

    Peptide
    Kisspeptin-10
    Outcome
    IncreaseCirculating LH during continuous infusion
    Study

    rhesus monkeyn: not reported in source

    Adult male rhesus monkey (Macaca mulatta)
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    200 or 400 microg/h · intravenous · continuous infusion, 24 hAs given in this study (rhesus monkey).

    Source sentences

    Summary
    Continuous iv infusion of hu metastin 45-54 at either 200 or 400 microg/h elicited a marked rise in circulating LH that peaked 2-3 h after initiation of treatment.
    1 context sentence
    Summary · context
    The present study extended this observation to the adult male monkey, a more preclinically relevant model in which robust activity in the hypothalamic-pituitary-testicular axis is present.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In adult male rhesus monkeys, LH fell back during continuous metastin 45-54 infusion and was similar to control by 24 h.

    In plain wordsIn adult male monkeys, LH fell back to the level of untreated animals within 24 hours of steady infusion.

    Peptide
    Kisspeptin-10
    Outcome
    No significant changeLH at 24 h of continuous infusion
    Study

    rhesus monkeyn: not reported in source

    Adult male rhesus monkey (Macaca mulatta)
    Comparator
    Control
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    200 or 400 microg/h · intravenous · 24 hAs given in this study (rhesus monkey).

    Source sentences

    Summary
    Thereafter, levels declined, and by 24 h, LH in metastin 45-54-infused animals was similar to control.
    1 context sentence
    Summary · context
    The present study extended this observation to the adult male monkey, a more preclinically relevant model in which robust activity in the hypothalamic-pituitary-testicular axis is present.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In adult male rhesus monkeys, LH release to a metastin 45-54 bolus was truncated at the low infusion dose and abolished at the high dose.

    In plain wordsIn adult male monkeys, after steady infusion, an extra dose of metastin 45-54 gave a smaller LH rise or none.

    Peptide
    Kisspeptin-10
    Outcome
    DecreaseLH response to iv bolus during continuous infusion
    Study

    rhesus monkeyn: not reported in source

    Adult male rhesus monkey (Macaca mulatta)
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    10-30 microg bolus during 200 or 400 microg/h infusion · intravenous · final 3 h of continuous infusionAs given in this study (rhesus monkey).

    Source sentences

    Summary
    LH release in response to an iv bolus of hu metastin 45-54 (10-30 microg) during the final 3 h of continuous infusion was truncated or abolished (low and high peptide dose, respectively).
    1 context sentence
    Summary · context
    The present study extended this observation to the adult male monkey, a more preclinically relevant model in which robust activity in the hypothalamic-pituitary-testicular axis is present.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In adult male rhesus monkeys, high-dose metastin 45-54 infusion, with GPR54 desensitization, was associated with a compromised pituitary response to a GnRH bolus.

    In plain wordsIn adult male monkeys, high-dose steady infusion was linked to a weaker pituitary response to GnRH.

    Peptide
    Kisspeptin-10
    Outcome
    DecreasePituitary response to GnRH bolus during high-dose infusion
    Study

    rhesus monkeyn: not reported in source

    Adult male rhesus monkey (Macaca mulatta)
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    400 microg/h · intravenousAs given in this study (rhesus monkey).

    Source sentences

    Summary
    GPR54 desensitization by the high-dose metastin 45-54 infusion was associated with compromised pituitary response to a bolus GnRH injection (0.3 microg).
    1 context sentence
    Summary · context
    The present study extended this observation to the adult male monkey, a more preclinically relevant model in which robust activity in the hypothalamic-pituitary-testicular axis is present.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In adult male rhesus monkeys, LH pulse amplitude was markedly suppressed during high-dose metastin 45-54 treatment.

    In plain wordsIn adult male monkeys, high-dose steady infusion strongly reduced the size of LH pulses.

    Peptide
    Kisspeptin-10
    Outcome
    DecreaseLH pulse amplitude during high-dose infusion
    Study

    rhesus monkeyn: not reported in source

    Adult male rhesus monkey (Macaca mulatta)
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    high dose · intravenousAs given in this study (rhesus monkey).

    Source sentences

    Summary
    LH pulse amplitude and pulse frequency were markedly suppressed during high-dose metastin 45-54 treatment.
    1 context sentence
    Summary · context
    The present study extended this observation to the adult male monkey, a more preclinically relevant model in which robust activity in the hypothalamic-pituitary-testicular axis is present.
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In adult male rhesus monkeys, LH pulse frequency was markedly suppressed during high-dose metastin 45-54 treatment.

    In plain wordsIn adult male monkeys, high-dose steady infusion strongly reduced how often LH pulses came.

    Peptide
    Kisspeptin-10
    Outcome
    DecreaseLH pulse frequency during high-dose infusion
    Study

    rhesus monkeyn: not reported in source

    Adult male rhesus monkey (Macaca mulatta)
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    high dose · intravenousAs given in this study (rhesus monkey).

    Source sentences

    Summary
    LH pulse amplitude and pulse frequency were markedly suppressed during high-dose metastin 45-54 treatment.
    1 context sentence
    Summary · context
    The present study extended this observation to the adult male monkey, a more preclinically relevant model in which robust activity in the hypothalamic-pituitary-testicular axis is present.
  7. 07AnimalAnimal study (in vivo)Efficacy outcome

    In adult male rhesus monkeys, at a given LH concentration, testosterone was higher during high-dose metastin 45-54 infusion than during vehicle.

    In plain wordsIn adult male monkeys, for the same LH level, testosterone was higher during high-dose infusion than with vehicle.

    Peptide
    Kisspeptin-10
    Outcome
    IncreaseTestosterone relative to LH during high-dose infusion
    Study

    rhesus monkeyn: not reported in source

    Adult male rhesus monkey (Macaca mulatta)
    Comparator
    Vehicle
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    high dose · intravenousAs given in this study (rhesus monkey).

    Source sentences

    Summary
    Thus, for a given concentration of LH, T levels were invariably higher during the high-dose metastin 45-54 infusion than during vehicle
    1 context sentence
    Summary · context
    The present study extended this observation to the adult male monkey, a more preclinically relevant model in which robust activity in the hypothalamic-pituitary-testicular axis is present.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 09:43 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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