[Effects of noopept and cortexin on the behavior of matured rats treated with corticoliberin or 70-kDa heat shock proteins in early ontogeny].

Shabanov PD, Lebedev AA, Stetsenko VP, Lavrov NV, Sablina GV, Gudasheva TA, Ostrovaskaia RU

Eksperimental'naia i klinicheskaia farmakologiia1 Jan 2007

PMID17402584PepBankPUB-17402584

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

6 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Other
In adult rats, early CRH or HSP-70 exposure significantly altered Noopept action.
In plain wordsIn rats, early exposure to CRH or HSP-70 changed the later effects of Noopept.
Peptide
Noopept (omberacetam)
Outcome
MixedModification of drug action by early stress-system exposure
Study
ratn: not reported in source
Adult Wistar rats exposed to CRH or HSP-70 in early ontogeny
Outcome group
Receptor activity and mechanism · Mental health and mood
Studied dose
1 mg/kg · intraperitonealAs given in this study (rat).
Source sentences
Summary
The activation of stress or antistress systems with CRH or HSP-70 significantly altered the drug action.
2 context sentences(design, population, supporting numbers)
Summary · context
Young Wistar rats aged 4 days were injected intraperitoneally with corticotropin releasing hormone (CRH), which is an agent activating the stress system, or 70-kDa heat shock proteins (HSP-70)--intracellular shaperons, possessing antistress properties.
Summary · context
In grown adult rats aged 90-100 days, the effects of nootropic drugs noopept and cortexin (1 mg/kg, i.p.) were assessed.
Report a problemFND-1740258401
02AnimalAnimal study (in vivo)Other
In adult rats exposed early to CRH or HSP-70, Noopept effects differed between males and females.
In plain wordsIn rats exposed early to CRH or HSP-70, Noopept effects differed between males and females.
Peptide
Noopept (omberacetam)
Outcome
MixedSex-dependent effects
Study
ratn: not reported in source
Adult Wistar rats exposed to CRH or HSP-70 in early ontogeny
Outcome group
Receptor activity and mechanism · Mental health and mood
Studied dose
1 mg/kg · intraperitonealAs given in this study (rat).
Source sentences
Summary
The effects were different in males and females and depended on animal gender.
2 context sentences(design, population, supporting numbers)
Summary · context
Young Wistar rats aged 4 days were injected intraperitoneally with corticotropin releasing hormone (CRH), which is an agent activating the stress system, or 70-kDa heat shock proteins (HSP-70)--intracellular shaperons, possessing antistress properties.
Summary · context
In grown adult rats aged 90-100 days, the effects of nootropic drugs noopept and cortexin (1 mg/kg, i.p.) were assessed.
Report a problemFND-1740258402
03AnimalAnimal study (in vivo)Efficacy outcome
In adult rats exposed early to CRH or HSP-70, Noopept demonstrated preferential psychoactivating effects.
In plain wordsIn rats exposed early to CRH or HSP-70, Noopept showed psychoactivating effects.
Peptide
Noopept (omberacetam)
Outcome
IncreasePsychoactivating effect
Study
ratn: not reported in source
Adult Wistar rats exposed to CRH or HSP-70 in early ontogeny
Outcome group
Anxiety and mood · Mental health and mood
Studied dose
1 mg/kg · intraperitonealAs given in this study (rat).
Source sentences
Summary
The spectrum of pharmacological activity of noopept and cortexin changed: noopept demonstrated preferable psychoactivating and antiaggressive effects, whereas cortexin showed mild anxiolytic and antidepressant activity.
2 context sentences(design, population, supporting numbers)
Summary · context
Young Wistar rats aged 4 days were injected intraperitoneally with corticotropin releasing hormone (CRH), which is an agent activating the stress system, or 70-kDa heat shock proteins (HSP-70)--intracellular shaperons, possessing antistress properties.
Summary · context
In grown adult rats aged 90-100 days, the effects of nootropic drugs noopept and cortexin (1 mg/kg, i.p.) were assessed.
Report a problemFND-1740258403
04AnimalAnimal study (in vivo)Efficacy outcome
In adult rats exposed early to CRH or HSP-70, Noopept demonstrated preferential antiaggressive effects.
In plain wordsIn rats exposed early to CRH or HSP-70, Noopept showed effects that reduced aggression.
Peptide
Noopept (omberacetam)
Outcome
DecreaseAggression
Study
ratn: not reported in source
Adult Wistar rats exposed to CRH or HSP-70 in early ontogeny
Outcome group
Anxiety and mood · Mental health and mood
Studied dose
1 mg/kg · intraperitonealAs given in this study (rat).
Source sentences
Summary
The spectrum of pharmacological activity of noopept and cortexin changed: noopept demonstrated preferable psychoactivating and antiaggressive effects, whereas cortexin showed mild anxiolytic and antidepressant activity.
2 context sentences(design, population, supporting numbers)
Summary · context
Young Wistar rats aged 4 days were injected intraperitoneally with corticotropin releasing hormone (CRH), which is an agent activating the stress system, or 70-kDa heat shock proteins (HSP-70)--intracellular shaperons, possessing antistress properties.
Summary · context
In grown adult rats aged 90-100 days, the effects of nootropic drugs noopept and cortexin (1 mg/kg, i.p.) were assessed.
Report a problemFND-1740258404
05AnimalAnimal study (in vivo)Efficacy outcome
In adult rats exposed to CRH or HSP-70 early in life, Cortexin showed mild anxiolytic activity.
In plain wordsIn rats exposed to CRH or HSP-70 early in life, Cortexin showed mild anxiety-reducing activity.
Peptide
Cortexin (cortical polypeptide complex)
Outcome
DecreaseAnxiolytic activity
Study
ratn: not reported in source
Adult Wistar rats exposed to CRH or HSP-70 in early ontogeny
Outcome group
Anxiety and mood · Mental health and mood
Studied dose
1 mg/kg · intraperitonealAs given in this study (rat).
Source sentences
Summary
The spectrum of pharmacological activity of noopept and cortexin changed: noopept demonstrated preferable psychoactivating and antiaggressive effects, whereas cortexin showed mild anxiolytic and antidepressant activity.
2 context sentences(design, population, supporting numbers)
Summary · context
Young Wistar rats aged 4 days were injected intraperitoneally with corticotropin releasing hormone (CRH), which is an agent activating the stress system, or 70-kDa heat shock proteins (HSP-70)--intracellular shaperons, possessing antistress properties.
Summary · context
In grown adult rats aged 90-100 days, the effects of nootropic drugs noopept and cortexin (1 mg/kg, i.p.) were assessed.
Report a problemFND-1740258405
06AnimalAnimal study (in vivo)Efficacy outcome
In adult rats exposed to CRH or HSP-70 early in life, Cortexin showed mild antidepressant activity.
In plain wordsIn rats exposed to CRH or HSP-70 early in life, Cortexin showed mild antidepressant activity.
Peptide
Cortexin (cortical polypeptide complex)
Outcome
DecreaseAntidepressant activity
Study
ratn: not reported in source
Adult Wistar rats exposed to CRH or HSP-70 in early ontogeny
Outcome group
Anxiety and mood · Mental health and mood
Studied dose
1 mg/kg · intraperitonealAs given in this study (rat).
Source sentences
Summary
The spectrum of pharmacological activity of noopept and cortexin changed: noopept demonstrated preferable psychoactivating and antiaggressive effects, whereas cortexin showed mild anxiolytic and antidepressant activity.
2 context sentences(design, population, supporting numbers)
Summary · context
Young Wistar rats aged 4 days were injected intraperitoneally with corticotropin releasing hormone (CRH), which is an agent activating the stress system, or 70-kDa heat shock proteins (HSP-70)--intracellular shaperons, possessing antistress properties.
Summary · context
In grown adult rats aged 90-100 days, the effects of nootropic drugs noopept and cortexin (1 mg/kg, i.p.) were assessed.
Report a problemFND-1740258406

Studies that did not test the peptide alone2

In this study, Cortexin (cortical polypeptide complex) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Cortexin (cortical polypeptide complex).

07AnimalNot a test of Cortexin (cortical polypeptide complex) aloneAnimal study (in vivo)Mechanism
In adult rats, early CRH or HSP-70 exposure altered nootropic drug action, without a separate Cortexin estimate.
In plain wordsIn rats, early CRH or HSP-70 exposure altered drug effects. The abstract gives no separate Cortexin estimate.
Peptide
Cortexin (cortical polypeptide complex)
Outcome
MixedEarly stress-system modulation of drug action
Study
ratn: not reported in source
Adult Wistar rats exposed to CRH or HSP-70 in early ontogeny
Outcome group
Anxiety and mood · Mental health and mood
Source sentences
Summary
The activation of stress or antistress systems with CRH or HSP-70 significantly altered the drug action.
2 context sentences(design, population, supporting numbers)
Summary · context
Young Wistar rats aged 4 days were injected intraperitoneally with corticotropin releasing hormone (CRH), which is an agent activating the stress system, or 70-kDa heat shock proteins (HSP-70)--intracellular shaperons, possessing antistress properties.
Summary · context
In grown adult rats aged 90-100 days, the effects of nootropic drugs noopept and cortexin (1 mg/kg, i.p.) were assessed.
In this study, Cortexin (cortical polypeptide complex) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cortexin (cortical polypeptide complex).
Report a problemFND-1740258407
08AnimalNot a test of Cortexin (cortical polypeptide complex) aloneAnimal study (in vivo)Mechanism
In adult rats, nootropic drug effects differed between males and females, without a separate Cortexin estimate.
In plain wordsIn rats, drug effects differed between males and females. The abstract gives no separate Cortexin estimate.
Peptide
Cortexin (cortical polypeptide complex)
Outcome
MixedSex-dependent drug effects
Study
ratn: not reported in source
Adult Wistar rats exposed to CRH or HSP-70 in early ontogeny
Outcome group
Anxiety and mood · Mental health and mood
Source sentences
Summary
The effects were different in males and females and depended on animal gender.
2 context sentences(design, population, supporting numbers)
Summary · context
Young Wistar rats aged 4 days were injected intraperitoneally with corticotropin releasing hormone (CRH), which is an agent activating the stress system, or 70-kDa heat shock proteins (HSP-70)--intracellular shaperons, possessing antistress properties.
Summary · context
In grown adult rats aged 90-100 days, the effects of nootropic drugs noopept and cortexin (1 mg/kg, i.p.) were assessed.
In this study, Cortexin (cortical polypeptide complex) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cortexin (cortical polypeptide complex).
Report a problemFND-1740258408

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 3Current
21 Oct 2026, 18:59 UTC
Study data updated · source update from Europe PMC
Version 2
21 Oct 2026, 15:58 UTC
Study results updated
Version 1
21 Oct 2026, 12:50 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

Journal Article

MeSH terms

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