Matrix metalloproteinase activity is necessary for thymosin beta 4 promotion of epithelial cell migration.

Qiu P, Kurpakus-Wheater M, Sosne G

Journal of cellular physiology1 Jul 2007Cited by 28 (Europe PMC)

PMID17348036DOI10.1002/jcp.21012PepBankPUB-17348036

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

2 results from studies that gave the peptide. No result from this study comes from people.

01LabIn vitro (cells)Mechanism
Tbeta4 upregulated MMP-1 gene expression in primary and transformed human corneal epithelial cells after scrape wounding.
In plain wordsIn human corneal cells in the lab, thymosin beta‑4 raised MMP-1 gene activity after a scrape wound.
Peptide
Thymosin beta-4 (human)
Outcome
IncreaseMMP-1 gene expression after scrape wounding
Study
humann: not reported in source
primary human corneal epithelial cells and transformed human corneal epithelial cells
Outcome group
Wound healing · Eye
Studied dose
Dose not stated
Source sentences
Summary
Tbeta(4) upregulated MMP-1 gene and protein expression in primary human corneal epithelial cells and in transformed human corneal epithelial cells following scrape wounding.
1 context sentence(design, population, supporting numbers)
Summary · context
In this study we investigated the role of MMPs in Tbeta(4)-stimulated corneal epithelial cell migration.
Report a problemFND-1734803604
02LabIn vitro (cells)Mechanism
Tbeta4 upregulated MMP-1 protein expression in primary and transformed human corneal epithelial cells after scrape wounding.
In plain wordsIn human corneal cells in the lab, thymosin beta‑4 raised MMP-1 protein levels after a scrape wound.
Peptide
Thymosin beta-4 (human)
Outcome
IncreaseMMP-1 protein expression after scrape wounding
Study
humann: not reported in source
primary human corneal epithelial cells and transformed human corneal epithelial cells
Outcome group
Wound healing · Eye
Studied dose
Dose not stated
Source sentences
Summary
Tbeta(4) upregulated MMP-1 gene and protein expression in primary human corneal epithelial cells and in transformed human corneal epithelial cells following scrape wounding.
1 context sentence(design, population, supporting numbers)
Summary · context
In this study we investigated the role of MMPs in Tbeta(4)-stimulated corneal epithelial cell migration.
Report a problemFND-1734803605

Studies that did not test the peptide alone3

In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Thymosin beta-4 (human).

03LabNot a test of Thymosin beta-4 (human) aloneIn vitro (cells)Mechanism
In Boyden chamber assays, the MMP activation inhibitor XG076 had no effect on epithelial cell migration stimulated by exogenous activated MMP-1.
In plain wordsIn lab tests, an MMP activation blocker did not change cell migration driven by added active MMP-1.
Peptide
Thymosin beta-4 (human)
Outcome
No significant changeCell migration stimulated by activated MMP-1, with XG076
Study
n: not reported in source
corneal epithelial cells
Outcome group
Wound healing · Eye
Source sentences
Summary
In Boyden chamber assays, XG076, an inhibitor of the conversion of pro- to active MMPs, had no effect on epithelial cell migration stimulated by exogenous activated MMP-1.
1 context sentence(design, population, supporting numbers)
Summary · context
In this study we investigated the role of MMPs in Tbeta(4)-stimulated corneal epithelial cell migration.
In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).
Report a problemFND-1734803601
04LabNot a test of Thymosin beta-4 (human) aloneIn vitro (cells)Mechanism
When pro-MMP activation was blocked, XG076 significantly inhibited cell migration and wound healing in the presence or absence of Tbeta4.
In plain wordsIn lab tests, blocking MMP activation reduced cell migration and wound healing, with or without thymosin beta‑4 present.
Peptide
Thymosin beta-4 (human)
Outcome
DecreaseCell migration and wound healing with XG076, with or without Tbeta4
Study
n: not reported in source
corneal epithelial cells
Outcome group
Wound healing · Eye
Source sentences
Summary
However, in in vitro migration assays where the activation of pro-MMPs was blocked, XG076 significantly inhibited cell migration and wound healing in the presence or absence of Tbeta(4).
1 context sentence(design, population, supporting numbers)
Summary · context
In this study we investigated the role of MMPs in Tbeta(4)-stimulated corneal epithelial cell migration.
In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).
Report a problemFND-1734803602
05LabNot a test of Thymosin beta-4 (human) aloneIn vitro (cells)Mechanism
The broad-spectrum active MMP inhibitor GM6001 and selective MMP inhibitors suppressed Tbeta4-stimulated cell migration.
In plain wordsIn lab tests, MMP blockers reduced the cell migration that thymosin beta‑4 stimulated.
Peptide
Thymosin beta-4 (human)
Outcome
DecreaseTbeta4-stimulated cell migration with MMP inhibitors
Study
n: not reported in source
corneal epithelial cells
Outcome group
Wound healing · Eye
Source sentences
Summary
GM6001, a broad-spectrum inhibitor of active MMPs and selective MMP inhibitors, also suppressed Tbeta(4)-stimulated cell migration.
1 context sentence(design, population, supporting numbers)
Summary · context
In this study we investigated the role of MMPs in Tbeta(4)-stimulated corneal epithelial cell migration.
In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).
Report a problemFND-1734803603

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
13 Oct 2026, 01:52 UTC
Study results updated
Version 1
12 Oct 2026, 18:17 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

MeSH terms

PepBank is a research reference. Talk to a doctor before you use any peptide.