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Study · Animal study (in vivo) · mouse · 2007

5 results

The effect of a GnRH agonist on cryopreserved human ovarian grafts in severe combined immunodeficient mice.

Maltaris T, Beckmann MW, Binder H, Mueller A, Hoffmann I, Koelbl H, Dittrich R

Reproduction (Cambridge, England)1 Feb 2007Cited by 29 (Europe PMC)

PMID17307918 (opens in a new tab)DOI10.1530/rep-06-0061 (opens in a new tab)PepBankPUB-17307918
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In SCID mice without gonadotropin stimulation, triptorelin significantly reduced ovarian-graft follicles at all developmental stages.

    In plain wordsIn mice without gonadotropin stimulation, triptorelin reduced follicles at all stages in human ovarian grafts versus no agonist.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    DecreaseFollicles at all developmental stages without gonadotropin stimulation
    Study

    mousen: not reported in source

    SCID mice with cryopreserved human ovarian xenografts
    Comparator
    No GnRH agonist, without gonadotropin stimulation
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Triptorelin, a GnRH agonist, caused a significant reduction of follicles in all developmental stages in the non-gonadotropin-stimulated animals (P<0.001).
    2 context sentences
    Summary · context
    Human ovarian tissue from seven patients was cryopreserved with an open-freezing system and xenotransplanted in SCID mice.
    Summary · context
    Development of follicles, estradiol production, vaginal cytology, and uterus weight were assessed after 15 weeks with or without gonadotropin stimulation.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In gonadotropin-stimulated SCID mice, triptorelin did not significantly change primordial follicle counts in ovarian grafts.

    In plain wordsIn mice with gonadotropin stimulation, triptorelin did not significantly change primordial follicle counts versus no agonist.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    No significant changePrimordial follicle count with gonadotropin stimulation
    Study

    mousen: not reported in source

    SCID mice with cryopreserved human ovarian xenografts
    Comparator
    No GnRH agonist, with gonadotropin stimulation
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In gonadotropin-stimulated animals, GnRH agonist treatment has no significant effect on primordial, primary and preantral follicle count, whereas the antral follicles were significantly fewer (P = 0.03).
    2 context sentences
    Summary · context
    Human ovarian tissue from seven patients was cryopreserved with an open-freezing system and xenotransplanted in SCID mice.
    Summary · context
    Development of follicles, estradiol production, vaginal cytology, and uterus weight were assessed after 15 weeks with or without gonadotropin stimulation.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In gonadotropin-stimulated SCID mice, triptorelin did not significantly change primary follicle counts in ovarian grafts.

    In plain wordsIn mice with gonadotropin stimulation, triptorelin did not significantly change primary follicle counts versus no agonist.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    No significant changePrimary follicle count with gonadotropin stimulation
    Study

    mousen: not reported in source

    SCID mice with cryopreserved human ovarian xenografts
    Comparator
    No GnRH agonist, with gonadotropin stimulation
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In gonadotropin-stimulated animals, GnRH agonist treatment has no significant effect on primordial, primary and preantral follicle count, whereas the antral follicles were significantly fewer (P = 0.03).
    2 context sentences
    Summary · context
    Human ovarian tissue from seven patients was cryopreserved with an open-freezing system and xenotransplanted in SCID mice.
    Summary · context
    Development of follicles, estradiol production, vaginal cytology, and uterus weight were assessed after 15 weeks with or without gonadotropin stimulation.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In gonadotropin-stimulated SCID mice, triptorelin did not significantly change preantral follicle counts in ovarian grafts.

    In plain wordsIn mice with gonadotropin stimulation, triptorelin did not significantly change preantral follicle counts versus no agonist.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    No significant changePreantral follicle count with gonadotropin stimulation
    Study

    mousen: not reported in source

    SCID mice with cryopreserved human ovarian xenografts
    Comparator
    No GnRH agonist, with gonadotropin stimulation
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In gonadotropin-stimulated animals, GnRH agonist treatment has no significant effect on primordial, primary and preantral follicle count, whereas the antral follicles were significantly fewer (P = 0.03).
    2 context sentences
    Summary · context
    Human ovarian tissue from seven patients was cryopreserved with an open-freezing system and xenotransplanted in SCID mice.
    Summary · context
    Development of follicles, estradiol production, vaginal cytology, and uterus weight were assessed after 15 weeks with or without gonadotropin stimulation.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In gonadotropin-stimulated SCID mice, triptorelin significantly reduced antral follicles in ovarian grafts.

    In plain wordsIn mice with gonadotropin stimulation, triptorelin reduced antral follicles in human ovarian grafts versus no agonist.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    DecreaseAntral follicle count with gonadotropin stimulation
    Study

    mousen: not reported in source

    SCID mice with cryopreserved human ovarian xenografts
    Comparator
    No GnRH agonist, with gonadotropin stimulation
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In gonadotropin-stimulated animals, GnRH agonist treatment has no significant effect on primordial, primary and preantral follicle count, whereas the antral follicles were significantly fewer (P = 0.03).
    2 context sentences
    Summary · context
    Human ovarian tissue from seven patients was cryopreserved with an open-freezing system and xenotransplanted in SCID mice.
    Summary · context
    Development of follicles, estradiol production, vaginal cytology, and uterus weight were assessed after 15 weeks with or without gonadotropin stimulation.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Registered trials1

Trials this study reports on, or that list this study as a reference. Registry data from ClinicalTrials.gov.

1 trial · 1 completed · 1 with posted results · source ClinicalTrials.gov (opens in a new tab)

CompletedPhase 3Results postedNCT02518191

Effects of GnRHa on Ovarian Function Against Chemotherapy-induced-gonadotoxicity

Xiangyun Zongn = 3451 Sept 2015 to 12 Jan 2021

Breast Cancer

Trial pageClinicalTrials.govUpdated 11 Jun 2021

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    22 Oct 2026, 02:26 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 18:59 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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