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Study · Animal study (in vivo) · rat · 2007

6 results

Inhibition of metastin (kisspeptin-54)-GPR54 signaling in the arcuate nucleus-median eminence region during lactation in rats.

Yamada S, Uenoyama Y, Kinoshita M, Iwata K, Takase K, Matsui H, Adachi S, Inoue K, Maeda KI, Tsukamura H

Endocrinology8 Feb 2007Cited by 116 (Europe PMC)

PMID17289848 (opens in a new tab)DOI10.1210/en.2006-1529 (opens in a new tab)PepBankPUB-17289848
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In lactating ovariectomized rats, metastin (kisspeptin‑54) injected into the third ventricle significantly increased LH secretion.

    In plain wordsIn lactating rats, kisspeptin‑54 injected into the brain raised LH release.

    Peptide
    Kisspeptin-54 (metastin)
    Outcome
    IncreaseLH secretion after third-ventricle metastin in lactating OVX rats
    Study

    ratn: not reported in source

    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    0.02, 0.2 and 2 nmol · third ventricle injectionAs given in this study (rat).

    Source sentences

    Summary
    Various doses of metastin (kisspeptin-54) (0.02, 0.2, and 2 nmol) injected into the third ventricle caused a significant increase in LH secretion in both lactating and nonlactating OVX rats, suggesting that lactating rats are responsive to metastin (kisspeptin-54) stimulus.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In nonlactating ovariectomized rats, metastin (kisspeptin‑54) injected into the third ventricle significantly increased LH secretion.

    In plain wordsIn nonlactating rats, kisspeptin‑54 injected into the brain raised LH release.

    Peptide
    Kisspeptin-54 (metastin)
    Outcome
    IncreaseLH secretion after third-ventricle metastin in nonlactating OVX rats
    Study

    ratn: not reported in source

    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    0.02, 0.2 and 2 nmol · third ventricle injectionAs given in this study (rat).

    Source sentences

    Summary
    Various doses of metastin (kisspeptin-54) (0.02, 0.2, and 2 nmol) injected into the third ventricle caused a significant increase in LH secretion in both lactating and nonlactating OVX rats, suggesting that lactating rats are responsive to metastin (kisspeptin-54) stimulus.

Natural levels measured4

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 03AnimalEndogenous levelAnimal study (in vivo)Other

    In lactating ovariectomized rats, natural KiSS-1 mRNA in the arcuate nucleus-median eminence region was lower than in nonlactating controls.

    In plain wordsIn lactating rats, the brain's own kisspeptin gene activity in this region was lower than in nonlactating rats.

    Peptide
    Kisspeptin-54 (metastin)
    Outcome
    DecreaseKiSS-1 mRNA in ARC-median eminence, lactating OVX rats
    Study

    ratn: not reported in source

    Comparator
    Nonlactating controls
    Outcome group
    Sex hormones and fertility · Endocrine and hormones

    Source sentences

    Summary
    Quantitative RT-PCR revealed that the KiSS-1 mRNA level was significantly lower in the arcuate nucleus (ARC)-median eminence region in lactating ovariectomized (OVX) and estrogen-treated OVX rats than in nonlactating controls.

    This result measures the body's own Kisspeptin-54 (metastin). Nobody was given the peptide. It is not evidence about taking it.

  2. 04AnimalEndogenous levelAnimal study (in vivo)Other

    In lactating estrogen-treated ovariectomized rats, natural KiSS-1 mRNA in the arcuate nucleus-median eminence region was lower than in nonlactating controls.

    In plain wordsIn lactating rats given estrogen, the brain's own kisspeptin gene activity in this region was lower than in nonlactating rats.

    Peptide
    Kisspeptin-54 (metastin)
    Outcome
    DecreaseKiSS-1 mRNA in ARC-median eminence, lactating estrogen-treated OVX rats
    Study

    ratn: not reported in source

    Comparator
    Nonlactating controls
    Outcome group
    Sex hormones and fertility · Endocrine and hormones

    Source sentences

    Summary
    Quantitative RT-PCR revealed that the KiSS-1 mRNA level was significantly lower in the arcuate nucleus (ARC)-median eminence region in lactating ovariectomized (OVX) and estrogen-treated OVX rats than in nonlactating controls.

    This result measures the body's own Kisspeptin-54 (metastin). Nobody was given the peptide. It is not evidence about taking it.

  3. 05AnimalEndogenous levelAnimal study (in vivo)Other

    In lactating and nonlactating rats, natural KiSS-1 mRNA in the anteroventral periventricular nucleus stayed at a low level despite estrogen treatment.

    In plain wordsIn lactating and nonlactating rats, the brain's own kisspeptin gene activity in this region stayed low even with estrogen.

    Peptide
    Kisspeptin-54 (metastin)
    Outcome
    No significant changeKiSS-1 mRNA in anteroventral periventricular nucleus
    Study

    ratn: not reported in source

    Comparator
    Nonlactating rats
    Outcome group
    Sex hormones and fertility · Endocrine and hormones

    Source sentences

    Summary
    KiSS-1 mRNA in the anteroventral periventricular nucleus was kept at a low level in both lactating and nonlactating rats despite estrogen treatment.

    This result measures the body's own Kisspeptin-54 (metastin). Nobody was given the peptide. It is not evidence about taking it.

  4. 06AnimalEndogenous levelAnimal study (in vivo)Other

    In lactating ovariectomized rats, few KiSS-1 mRNA-expressing cells or natural metastin immunoreactivities were found in the arcuate nucleus, compared with dense expression in nonlactating controls.

    In plain wordsIn lactating rats, the brain's own kisspeptin and the cells that make it were scarce in this region compared with nonlactating rats.

    Peptide
    Kisspeptin-54 (metastin)
    Outcome
    DecreaseKiSS-1 mRNA-expressing cells and metastin immunoreactivity in ARC
    Study

    ratn: not reported in source

    Comparator
    Nonlactating controls
    Outcome group
    Sex hormones and fertility · Endocrine and hormones

    Source sentences

    Summary
    Although KiSS-1 mRNA-expressing cells or metastin (kisspeptin-54) immunoreactivities were densely located in the ARC of nonlactating controls, few were found in the ARC of lactating OVX animals.

    This result measures the body's own Kisspeptin-54 (metastin). Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

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