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Study · In vitro (cells) · mouse · 2007

3 results

Thymosin beta4 and thymosin beta4-derived peptides induce mast cell exocytosis.

Wyczółkowska J, Walczak-Drzewiecka A, Wagner W, Dastych J

Peptides13 Jan 2007Cited by 11 (Europe PMC)

PMID17289217 (opens in a new tab)DOI10.1016/j.peptides.2007.01.004 (opens in a new tab)PepBankPUB-17289217
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

1 result from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Activity measurement

    In murine peritoneal and human HMC-1 mast cells, Tbeta4 at 0.2-2000nM induced mediator release of up to 23% in a concentration-dependent manner.

    In plain wordsIn lab tests on mouse and human mast cells, thymosin beta‑4 caused the cells to release mediators, more with higher concentrations.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseMast cell mediator release
    Study

    mouse and humann: not reported in source

    murine peritoneal mast cells and human HMC-1 mast cells
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    0.2-2000nMAs given in this study (mouse and human).

    Measurements

    mediator release
    ≤ 23%
    murine peritoneal and HMC-1 mast cells

    Source sentences

    Summary
    Exposure to 0.2-2000nM Tbeta4 induced mediator release (up to 23%) in murine peritoneal and human HMC-1 mast cells in a concentration-dependent manner.
    1 context sentence
    Summary · context
    Mast cells are involved in these processes as well and therefore we investigated the effect of Tbeta4 on mast cells.

Studies that did not test the peptide alone2

In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Thymosin beta-4 (human).

  1. 02LabNot a test of Thymosin beta-4 (human) aloneIn vitro (cells)Activity measurement

    The Tbeta4 N-terminal fragment AcSDKP caused low but detectable mediator release in mast cells.

    In plain wordsIn lab tests, a short N-terminal piece of thymosin beta‑4 caused low but detectable mediator release from mast cells.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseMast cell mediator release by AcSDKP fragment
    Study

    mouse and humann: not reported in source

    murine peritoneal mast cells and human HMC-1 mast cells
    Outcome group
    Immune response · Immune and inflammation

    Source sentences

    Summary
    While the peptide AcSDKP, matching the 4 N-terminal amino acid residues of Tbeta4, mediated low but detectable mediator release
    1 context sentence
    Summary · context
    Mast cells are involved in these processes as well and therefore we investigated the effect of Tbeta4 on mast cells.

    In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).

  2. 03LabNot a test of Thymosin beta-4 (human) aloneIn vitro (cells)Activity measurement

    Tbeta4 fragments 16-38 and 17-23 stimulated mast cell mediator release at a level equal to or higher than native Tbeta4.

    In plain wordsIn lab tests, two pieces of thymosin beta‑4 made mast cells release mediators as much as or more than the whole peptide.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseMast cell mediator release by Tbeta4 fragments 16-38 and 17-23
    Study

    mouse and humann: not reported in source

    murine peritoneal mast cells and human HMC-1 mast cells
    Comparator
    Native Tbeta4
    Outcome group
    Immune response · Immune and inflammation

    Source sentences

    Summary
    peptides corresponding to the Tbeta4 amino acid sequences 16-38 and 17-23 stimulated mast cells mediator release on a level equal to or higher than that observed with native Tbeta4.
    1 context sentence
    Summary · context
    Mast cells are involved in these processes as well and therefore we investigated the effect of Tbeta4 on mast cells.

    In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 01:52 UTC

    Study results updated

  2. Version 1

    12 Oct 2026, 18:17 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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