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Study · In vitro (cells) · 2007

4 results

Thymosin beta 4 suppression of corneal NFkappaB: a potential anti-inflammatory pathway.

Sosne G, Qiu P, Christopherson PL, Wheater MK

Experimental eye research23 Jan 2007Cited by 121 (Europe PMC)

PMID17254567 (opens in a new tab)PMCIDPMC2211446 (opens in a new tab)DOI10.1016/j.exer.2006.12.004 (opens in a new tab)PepBankPUB-17254567
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Mechanism

    In TNF-alpha-stimulated human corneal epithelial cells, Tbeta4 treatment significantly decreased nuclear NFkappaB protein levels versus non-treated controls.

    In plain wordsIn cells, thymosin beta‑4 lowered nuclear NFkappaB protein after TNF-alpha stimulation compared with untreated cells.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    DecreaseNuclear NFkappaB protein level
    Study

    humann: not reported in source

    Human corneal epithelial cells (HCET and HCEC) stimulated with TNF-alpha
    Comparator
    Non-treated controls
    Outcome group
    Inflammation markers · Eye
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Compared to non-treated controls, Tbeta4 treatment significantly decreased nuclear NFkappaB protein levels, NFkappaB activity and p65 subunit phosphorylation in corneal epithelial cells after TNF-alpha stimulation.
    1 context sentence
    Summary · context
    Transformed and primary (HCET and HCEC) human corneal epithelial cells were stimulated with the pro-inflammatory cytokine TNF-alpha and treated or not with Tbeta4.
  2. 02LabIn vitro (cells)Mechanism

    In TNF-alpha-stimulated human corneal epithelial cells, Tbeta4 treatment significantly decreased NFkappaB activity versus non-treated controls.

    In plain wordsIn cells, thymosin beta‑4 lowered NFkappaB activity after TNF-alpha stimulation compared with untreated cells.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    DecreaseNFkappaB activity
    Study

    humann: not reported in source

    Human corneal epithelial cells (HCET and HCEC) stimulated with TNF-alpha
    Comparator
    Non-treated controls
    Outcome group
    Inflammation markers · Eye
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Compared to non-treated controls, Tbeta4 treatment significantly decreased nuclear NFkappaB protein levels, NFkappaB activity and p65 subunit phosphorylation in corneal epithelial cells after TNF-alpha stimulation.
    1 context sentence
    Summary · context
    Transformed and primary (HCET and HCEC) human corneal epithelial cells were stimulated with the pro-inflammatory cytokine TNF-alpha and treated or not with Tbeta4.
  3. 03LabIn vitro (cells)Mechanism

    In TNF-alpha-stimulated human corneal epithelial cells, Tbeta4 treatment significantly decreased p65 subunit phosphorylation versus non-treated controls.

    In plain wordsIn cells, thymosin beta‑4 lowered p65 phosphorylation after TNF-alpha stimulation compared with untreated cells.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    DecreaseNFkappaB p65 subunit phosphorylation
    Study

    humann: not reported in source

    Human corneal epithelial cells (HCET and HCEC) stimulated with TNF-alpha
    Comparator
    Non-treated controls
    Outcome group
    Inflammation markers · Eye
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Compared to non-treated controls, Tbeta4 treatment significantly decreased nuclear NFkappaB protein levels, NFkappaB activity and p65 subunit phosphorylation in corneal epithelial cells after TNF-alpha stimulation.
    1 context sentence
    Summary · context
    Transformed and primary (HCET and HCEC) human corneal epithelial cells were stimulated with the pro-inflammatory cytokine TNF-alpha and treated or not with Tbeta4.
  4. 04LabIn vitro (cells)Mechanism

    In TNF-alpha-stimulated human corneal epithelial cells, Tbeta4 blocked nuclear translocation of the NFkappaB p65 subunit.

    In plain wordsIn cells, thymosin beta‑4 blocked the NFkappaB p65 protein from moving into the nucleus after TNF-alpha stimulation.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    DecreaseNFkappaB p65 nuclear translocation
    Study

    humann: not reported in source

    Human corneal epithelial cells (HCET and HCEC) stimulated with TNF-alpha
    Comparator
    Non-treated controls
    Outcome group
    Inflammation markers · Eye
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In TNF-alpha-stimulated corneal epithelial cells, NFkappaB p65 subunit translocation to the nucleus was observed using immunofluorescence microscopy. In contrast, Tbeta4 blocked nuclear translocation of the NFkappaB p65 subunit in TNF-alpha-stimulated corneal epithelial cells.
    1 context sentence
    Summary · context
    Transformed and primary (HCET and HCEC) human corneal epithelial cells were stimulated with the pro-inflammatory cytokine TNF-alpha and treated or not with Tbeta4.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 01:52 UTC

    Study results updated

  2. Version 1

    12 Oct 2026, 18:17 UTC

    First added · source update from Europe PMC

Subjects

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