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Study · Measured the body's own peptide · 2006

4 results

Conjunctival expression of thymosin-beta4 in vernal keratoconjunctivitis.

Micera A, Bonini S, Lambiase A, Lapucci G, Bonini S, Rasi G

Molecular vision20 Dec 2006Cited by 2 (Europe PMC)

PMID17200658 (opens in a new tab)PepBankPUB-17200658
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

No result from this study comes from a test of the peptide.

Natural levels measured4

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01HumanEndogenous levelObservational studyOther

    In patients with vernal keratoconjunctivitis, the body's own Tbeta4 mRNA was upregulated in conjunctival biopsies compared with healthy specimens.

    In plain wordsIn people with vernal keratoconjunctivitis, the body's own thymosin beta4 mRNA was higher in eye tissue than in healthy people.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseTbeta4 mRNA in conjunctival biopsies
    Study

    n = 12

    Comparator
    Healthy conjunctiva
    Outcome group
    Inflammation markers · Eye

    Source sentences

    Summary
    Compared to healthy specimens, Tbeta4 mRNA appeared upregulated in VKC conjunctival biopsies as detected by real-time PCR.
    1 context sentence
    Summary · context
    Conjunctival tissues, obtained from seven VKC patients and five sex/age-matched healthy subjects, were evaluated for Tbeta4 expression by relative real time-PCR and light/confocal microscopy.

    This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.

  2. 02HumanEndogenous levelObservational studyOther

    In vernal keratoconjunctivitis, the body's own Tbeta4 immunoreactivity was selectively increased in the conjunctival stroma.

    In plain wordsIn people with vernal keratoconjunctivitis, the body's own thymosin beta4 was higher in the deeper eye tissue.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseTbeta4 immunoreactivity in conjunctival stroma
    Study

    n = 12

    Comparator
    Healthy conjunctiva
    Outcome group
    Inflammation markers · Eye

    Source sentences

    Summary
    In VKC conjunctival sections, Tbeta4 immunoreactivity was selectively increased in the stroma where, by confocal analysis of VKC papillary formations, Tbeta4 appeared to be mostly localized in eosinophils and activated fibroblasts/myofibroblasts.
    1 context sentence
    Summary · context
    Conjunctival tissues, obtained from seven VKC patients and five sex/age-matched healthy subjects, were evaluated for Tbeta4 expression by relative real time-PCR and light/confocal microscopy.

    This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.

  3. 03HumanEndogenous levelObservational studyOther

    In vernal keratoconjunctivitis papillary formations, the body's own Tbeta4 appeared mostly in eosinophils and activated fibroblasts or myofibroblasts.

    In plain wordsIn people with vernal keratoconjunctivitis, the body's own thymosin beta4 was found mostly in eosinophils and activated fibroblasts.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    Not applicableCellular localization of Tbeta4 in VKC lesions
    Study

    n = 7

    Outcome group
    Inflammation markers · Eye

    Source sentences

    Summary
    by confocal analysis of VKC papillary formations, Tbeta4 appeared to be mostly localized in eosinophils and activated fibroblasts/myofibroblasts.
    1 context sentence
    Summary · context
    Conjunctival tissues, obtained from seven VKC patients and five sex/age-matched healthy subjects, were evaluated for Tbeta4 expression by relative real time-PCR and light/confocal microscopy.

    This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.

  4. 04HumanEndogenous levelObservational studyOther

    In healthy conjunctiva, the body's own Tbeta4 protein was confined to the epithelium, with weak staining in the stroma.

    In plain wordsIn healthy eye tissue, the body's own thymosin beta4 was found mainly in the surface layer.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    Not applicableTbeta4 protein in healthy conjunctiva
    Study

    n = 5

    Outcome group
    Inflammation markers · Eye

    Source sentences

    Summary
    In the healthy conjunctiva, Tbeta4 protein expression was confined to the conjunctival epithelium, while a weak staining was observed in the stroma.
    1 context sentence
    Summary · context
    Conjunctival tissues, obtained from seven VKC patients and five sex/age-matched healthy subjects, were evaluated for Tbeta4 expression by relative real time-PCR and light/confocal microscopy.

    This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 01:52 UTC

    Study results updated

  2. Version 1

    12 Oct 2026, 18:17 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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