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Study · In vitro (cells) · 2007

5 results

Internalization is essential for the antiapoptotic effects of exogenous thymosin beta-4 on human corneal epithelial cells.

Ho JH, Chuang CH, Ho CY, Shih YR, Lee OK, Su Y

Investigative ophthalmology & visual science1 Jan 2007Cited by 38 (Europe PMC)

PMID17197512 (opens in a new tab)DOI10.1167/iovs.06-0826 (opens in a new tab)PepBankPUB-17197512
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Efficacy outcome

    In human corneal epithelial T cells, pretreatment with recombinant Tbeta(4) dramatically reduced cell death induced by FasL.

    In plain wordsIn cells, thymosin beta‑4 pretreatment greatly reduced death of human corneal cells caused by FasL.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    DecreaseFasL-induced HCE-T cell death
    Study

    humann: not reported in source

    SV40-immortalized human corneal epithelial T (HCE-T) cells
    Comparator
    Cells without Tbeta(4)
    Outcome group
    Neuroprotection · Eye
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The death of HCE-T cells induced by both FasL and H(2)O(2) was dramatically reduced by the recombinant Tbeta(4) pretreatment.
    1 context sentence
    Summary · context
    HCE-T cells were incubated without or with the recombinant histidine-tagged Tbeta(4) produced by Escherichia coli before the addition of FasL or H(2)O(2).
  2. 02LabIn vitro (cells)Efficacy outcome

    In human corneal epithelial T cells, pretreatment with recombinant Tbeta(4) dramatically reduced cell death induced by hydrogen peroxide.

    In plain wordsIn cells, thymosin beta‑4 pretreatment greatly reduced death of human corneal cells caused by hydrogen peroxide.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    DecreaseH2O2-induced HCE-T cell death
    Study

    humann: not reported in source

    SV40-immortalized human corneal epithelial T (HCE-T) cells
    Comparator
    Cells without Tbeta(4)
    Outcome group
    Neuroprotection · Eye
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The death of HCE-T cells induced by both FasL and H(2)O(2) was dramatically reduced by the recombinant Tbeta(4) pretreatment.
    1 context sentence
    Summary · context
    HCE-T cells were incubated without or with the recombinant histidine-tagged Tbeta(4) produced by Escherichia coli before the addition of FasL or H(2)O(2).
  3. 03LabIn vitro (cells)Mechanism

    In HCE-T cells, preincubation with exogenous Tbeta(4) abolished FasL-mediated activation of caspases-8 and -3.

    In plain wordsIn cells, thymosin beta‑4 preincubation stopped FasL from switching on the cell-death enzymes caspase-8 and caspase-3.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    DecreaseFasL-mediated activation of caspases-8 and -3
    Study

    humann: not reported in source

    SV40-immortalized human corneal epithelial T (HCE-T) cells
    Comparator
    Cells without Tbeta(4)
    Outcome group
    Receptor activity and mechanism · Eye
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Moreover, FasL-mediated activation of caspases-8 and -3 as well as H(2)O(2)-triggered stimulation of caspases-9 and -3 in these cells was abolished by preincubating them with the exogenous Tbeta(4).
    1 context sentence
    Summary · context
    HCE-T cells were incubated without or with the recombinant histidine-tagged Tbeta(4) produced by Escherichia coli before the addition of FasL or H(2)O(2).
  4. 04LabIn vitro (cells)Mechanism

    In HCE-T cells, preincubation with exogenous Tbeta(4) abolished hydrogen peroxide-triggered activation of caspases-9 and -3.

    In plain wordsIn cells, thymosin beta‑4 preincubation stopped hydrogen peroxide from switching on the cell-death enzymes caspase-9 and caspase-3.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    DecreaseH2O2-triggered activation of caspases-9 and -3
    Study

    humann: not reported in source

    SV40-immortalized human corneal epithelial T (HCE-T) cells
    Comparator
    Cells without Tbeta(4)
    Outcome group
    Receptor activity and mechanism · Eye
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Moreover, FasL-mediated activation of caspases-8 and -3 as well as H(2)O(2)-triggered stimulation of caspases-9 and -3 in these cells was abolished by preincubating them with the exogenous Tbeta(4).
    1 context sentence
    Summary · context
    HCE-T cells were incubated without or with the recombinant histidine-tagged Tbeta(4) produced by Escherichia coli before the addition of FasL or H(2)O(2).
  5. 05LabIn vitro (cells)Mechanism

    In HCE-T cells, blocking cellular entry of Tbeta(4) with cytochalasin D abrogated its cytoprotective effects, so internalization was essential.

    In plain wordsIn cells, blocking thymosin beta‑4 from entering cells with cytochalasin D removed its protection against cell death.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    DecreaseRole of Tbeta(4) internalization in cytoprotection (cytochalasin D)
    Study

    humann: not reported in source

    SV40-immortalized human corneal epithelial T (HCE-T) cells
    Comparator
    Tbeta(4) without cytochalasin D
    Outcome group
    Receptor activity and mechanism · Eye
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Of note, internalization of this G-actin-sequestering peptide into HCE-T cells was found to be essential in cell death prevention, in that disruption of the cellular entry of Tbeta(4) by cytochalasin D abrogated its cytoprotective effects.
    1 context sentence
    Summary · context
    HCE-T cells were incubated without or with the recombinant histidine-tagged Tbeta(4) produced by Escherichia coli before the addition of FasL or H(2)O(2).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 01:52 UTC

    Study results updated

  2. Version 1

    12 Oct 2026, 18:17 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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