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Study · Animal study (in vivo) · rat · 2006

3 results

Stable gastric pentadecapeptide BPC 157 in trials for inflammatory bowel disease (PL-10, PLD-116, PL 14736, Pliva, Croatia). Full and distended stomach, and vascular response.

Sikiric P, Seiwerth S, Brcic L, Blagaic AB, Zoricic I, Sever M, Klicek R, Radic B, Keller N, Sipos K, Jakir A, Udovicic M and 5 more

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Tonkic A, Kokic N, Turkovic B, Mise S, Anic T

Inflammopharmacology1 Dec 2006Cited by 38 (Europe PMC)

PMID17186181 (opens in a new tab)DOI10.1007/s10787-006-1531-7 (opens in a new tab)PepBankPUB-17186181
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats with a fully distended stomach given absolute alcohol, BPC‑157 instilled into the stomach inhibited lesions of the stomach, esophagus and duodenum.

    In plain wordsIn rats given alcohol in a full stomach, BPC‑157 put into the stomach reduced damage to the stomach, gullet and duodenum.

    Peptide
    BPC-157
    Outcome
    DecreaseGastric, esophageal and duodenal lesions after alcohol
    Study

    ratn: not reported in source

    Fully distended stomach with absolute alcohol instillation
    Outcome group
    Gastrointestinal protection · Gastrointestinal
    Studied dose
    Dose not stated · intragastricAs given in this study (rat).

    Source sentences

    Summary
    lesions of stomach, esophagus, and duodenum are inhibited.
    1 context sentence
    Summary · context
    After absolute alcohol instillation in fully distended rat stomach, gastric, esophageal and duodenal lesions occur.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In rats with a fully distended stomach given absolute alcohol, the left gastric artery vessels stayed visible after BPC‑157 instillation into the stomach.

    In plain wordsIn rats given alcohol in a full stomach, blood vessels of the stomach stayed visible after BPC‑157 was put into the stomach.

    Peptide
    BPC-157
    Outcome
    Not applicableGastric artery vessel presentation after alcohol
    Study

    ratn: not reported in source

    Fully distended stomach with absolute alcohol instillation
    Outcome group
    Gastrointestinal protection · Gastrointestinal
    Studied dose
    Dose not stated · intragastricAs given in this study (rat).

    Source sentences

    Summary
    After pentadecapeptide BPC 157 instillation into the stomach the vessels presentation remains constant
    1 context sentence
    Summary · context
    After absolute alcohol instillation in fully distended rat stomach, gastric, esophageal and duodenal lesions occur.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In rats with 12-20 months of untreated esophagitis, BPC‑157 given into the stomach recovered disturbed lower esophageal and pyloric sphincter pressure.

    In plain wordsIn rats with long untreated oesophagus inflammation, BPC‑157 given into the stomach restored disturbed pressure in the two stomach sphincters.

    Peptide
    BPC-157
    Outcome
    Direction not reportedLower esophageal and pyloric sphincter pressure
    Study

    ratn: not reported in source

    Untreated esophagitis for 12-20 months
    Outcome group
    Gastrointestinal protection · Gastrointestinal
    Studied dose
    Dose not stated · intragastricAs given in this study (rat).

    Source sentences

    Summary
    Given directly into the stomach, BPC 157 instantly recovers disturbed lower esophageal and pyloric sphincter pressure in rats after 12-20 months of untreated esophagitis.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    10 Oct 2026, 10:21 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 02:56 UTC

    First added · source update from Europe PMC

Subjects

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