Effects of a preovulatory administered depot gonadotrophin-releasing hormone agonist on reproductive hormone levels and pregnancy outcome in gilts.

Schneider F, Brüssow KP

Reproduction, fertility, and development1 Jan 2006Cited by 15 (Europe PMC)

PMID17147934DOI10.1071/rd06027PepBankPUB-17147934

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

7 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In gilts, four of six receiving depot triptorelin were pregnant on Day 28, compared with all six receiving Gonavet.
In plain wordsIn pigs, four of six receiving depot triptorelin were pregnant on Day 28, compared with all six receiving Gonavet.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
DecreasePregnancy at slaughter
Study
pign = 12
Gilts receiving preovulatory depot GnRH agonist
Comparator
Gonavet
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
Dose not stated
Measurements
Pregnant gilts
4 animals
depot triptorelin on Day 28
Pregnant gilts
6 animals
Gonavet on Day 28
Source sentences
Summary
In this treatment group (n = 6) four gilts were pregnant at slaughter on Day 28.
2 context sentences(design, population, supporting numbers)
Summary · context
In the control group receiving Gonavet, a non-formulated GnRHa (n = 6), all pigs showed LH pulses and were pregnant at slaughter on Day 28 of gestation.
Summary · context
The present study aimed to explore the influence of a preovulatory administered depot gonadotrophin-releasing hormone (GnRH) agonist (GnRHa; Decapeptyl Depot) on the endocrine parameters and pregnancy outcome of gilts (n = 6).
Report a problemFND-1714793404
02AnimalAnimal study (in vivo)Efficacy outcome
In gilts, early luteal progesterone was lower with depot triptorelin than in Gonavet-treated controls.
In plain wordsIn pigs, early luteal progesterone was lower with depot triptorelin than with Gonavet.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
DecreaseEarly luteal progesterone
Study
pign = 12
Gilts receiving preovulatory depot GnRH agonist
Comparator
Gonavet
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
Dose not stated
Source sentences
Summary
Mean progesterone concentrations were elevated in controls during the early luteal phase and were similar for both groups during the implantation period.
2 context sentences(design, population, supporting numbers)
Summary · context
In the control group receiving Gonavet, a non-formulated GnRHa (n = 6), all pigs showed LH pulses and were pregnant at slaughter on Day 28 of gestation.
Summary · context
The present study aimed to explore the influence of a preovulatory administered depot gonadotrophin-releasing hormone (GnRH) agonist (GnRHa; Decapeptyl Depot) on the endocrine parameters and pregnancy outcome of gilts (n = 6).
Report a problemFND-1714793405
03AnimalAnimal study (in vivo)Efficacy outcome
In gilts, progesterone during implantation was similar with depot triptorelin and Gonavet.
In plain wordsIn pigs, progesterone during implantation was similar with depot triptorelin and Gonavet.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
No significant changeImplantation-period progesterone
Study
pign = 12
Gilts receiving preovulatory depot GnRH agonist
Comparator
Gonavet
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
Dose not stated
Source sentences
Summary
Mean progesterone concentrations were elevated in controls during the early luteal phase and were similar for both groups during the implantation period.
2 context sentences(design, population, supporting numbers)
Summary · context
In the control group receiving Gonavet, a non-formulated GnRHa (n = 6), all pigs showed LH pulses and were pregnant at slaughter on Day 28 of gestation.
Summary · context
The present study aimed to explore the influence of a preovulatory administered depot gonadotrophin-releasing hormone (GnRH) agonist (GnRHa; Decapeptyl Depot) on the endocrine parameters and pregnancy outcome of gilts (n = 6).
Report a problemFND-1714793406
04AnimalAnimal study (in vivo)Efficacy outcome
In gilts, depot triptorelin had no treatment effect on unoccupied uterine progesterone receptor concentrations versus Gonavet.
In plain wordsIn pigs, unoccupied uterine progesterone receptor concentrations did not differ between depot triptorelin and Gonavet treatments.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
No significant changeUnoccupied uterine progesterone receptor
Study
pign = 12
Gilts receiving preovulatory depot GnRH agonist
Comparator
Gonavet
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
Dose not stated
Source sentences
Summary
Mean concentration of unoccupied progesterone receptor was significantly higher in uterine myometrium than in endometrium, but without treatment effects.
2 context sentences(design, population, supporting numbers)
Summary · context
In the control group receiving Gonavet, a non-formulated GnRHa (n = 6), all pigs showed LH pulses and were pregnant at slaughter on Day 28 of gestation.
Summary · context
The present study aimed to explore the influence of a preovulatory administered depot gonadotrophin-releasing hormone (GnRH) agonist (GnRHa; Decapeptyl Depot) on the endocrine parameters and pregnancy outcome of gilts (n = 6).
Report a problemFND-1714793407
05AnimalAnimal study (in vivo)Efficacy outcome
In gilts, a preovulatory LH surge occurred in all animals treated with depot triptorelin.
In plain wordsIn pigs, all gilts treated with depot triptorelin showed a preovulatory LH surge.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
IncreasePreovulatory LH surge
Study
pign = 6
Gilts receiving preovulatory depot GnRH agonist
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
Dose not stated
Source sentences
Summary
A GnRHa-supported preovulatory luteinising hormone (LH) surge was detected in all treated gilts.
1 context sentence(design, population, supporting numbers)
Summary · context
The present study aimed to explore the influence of a preovulatory administered depot gonadotrophin-releasing hormone (GnRH) agonist (GnRHa; Decapeptyl Depot) on the endocrine parameters and pregnancy outcome of gilts (n = 6).
Report a problemFND-1714793401
06AnimalAnimal study (in vivo)Efficacy outcome
In gilts, depot triptorelin completely abolished LH pulses on Day 7 of pregnancy.
In plain wordsIn pigs, depot triptorelin completely abolished LH pulses on Day 7 of pregnancy.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
DecreaseLH pulses on Day 7
Study
pign = 6
Gilts receiving preovulatory depot GnRH agonist
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
Dose not stated
Source sentences
Summary
LH pulses were abolished completely by depot GnRHa on Day 7 and partly on Day 21 of pregnancy.
1 context sentence(design, population, supporting numbers)
Summary · context
The present study aimed to explore the influence of a preovulatory administered depot gonadotrophin-releasing hormone (GnRH) agonist (GnRHa; Decapeptyl Depot) on the endocrine parameters and pregnancy outcome of gilts (n = 6).
Report a problemFND-1714793402
07AnimalAnimal study (in vivo)Efficacy outcome
In gilts, depot triptorelin partly abolished LH pulses on Day 21 of pregnancy.
In plain wordsIn pigs, depot triptorelin partly abolished LH pulses on Day 21 of pregnancy.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
DecreaseLH pulses on Day 21
Study
pign = 6
Gilts receiving preovulatory depot GnRH agonist
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
Dose not stated
Source sentences
Summary
LH pulses were abolished completely by depot GnRHa on Day 7 and partly on Day 21 of pregnancy.
1 context sentence(design, population, supporting numbers)
Summary · context
The present study aimed to explore the influence of a preovulatory administered depot gonadotrophin-releasing hormone (GnRH) agonist (GnRHa; Decapeptyl Depot) on the endocrine parameters and pregnancy outcome of gilts (n = 6).
Report a problemFND-1714793403

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
22 Oct 2026, 02:26 UTC
Study results updated
Version 1
21 Oct 2026, 18:59 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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Journal Article

MeSH terms

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