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Study · Not a test of the peptide alone · 2006

1 result

Point mutations in the melanocortin-4 receptor cause variable obesity in mice.

Meehan TP, Tabeta K, Du X, Woodward LS, Firozi K, Beutler B, Justice MJ

Mammalian genome : official journal of the International Mammalian Genome Society1 Dec 2006Cited by 17 (Europe PMC)

PMID17143585 (opens in a new tab)DOI10.1007/s00335-006-0073-z (opens in a new tab)PepBankPUB-17143585
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study1

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone1

In this study, Melanotan I (afamelanotide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Melanotan I (afamelanotide).

  1. 01LabNot a test of Melanotan I (afamelanotide) aloneIn vitro (cells)Activity measurement

    In HEK 293 cells, the Southbeach (L300P) mutant MC4R displayed minimal signaling when stimulated with NDP-alpha-MSH.

    In plain wordsIn cells, the Southbeach mutant receptor barely responded when NDP-alpha-MSH was applied.

    Peptide
    Melanotan I (afamelanotide)
    Outcome
    DecreaseReceptor signaling of Southbeach (L300P) MC4R
    Study

    n: not reported in source

    HEK 293 cells expressing mutant MC4R
    Outcome group
    Receptor activity and mechanism · Pharmacology

    Source sentences

    Summary
    In contrast, Southbeach (L300P) displays minimal receptor signaling when stimulated with the natural ligand alpha-MSH or the synthetic agonist NDP-alpha-MSH.
    1 context sentence
    Summary · context
    Expression of the mutant receptors in HEK 293 cells revealed defects in receptor signaling.

    In this study, Melanotan I (afamelanotide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Melanotan I (afamelanotide).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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