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Study · Animal study (in vivo) · mouse · 2007

10 results

A growth hormone-releasing peptide promotes mitochondrial biogenesis and a fat burning-like phenotype through scavenger receptor CD36 in white adipocytes.

Rodrigue-Way A, Demers A, Ong H, Tremblay A

Endocrinology30 Nov 2006Cited by 26 (Europe PMC)

PMID17138655 (opens in a new tab)DOI10.1210/en.2006-0975 (opens in a new tab)PepBankPUB-17138655
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study10

10 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In mice, hexarelin treatment produced a mitochondrial phenotype similar to that in cells in epididymal white fat.

    In plain wordsIn mice, hexarelin changed mitochondria in white fat in a way similar to the changes seen in fat cells in a dish.

    Peptide
    Hexarelin
    Outcome
    IncreaseMitochondrial phenotype in epididymal white fat
    Study

    mousen: not reported in source

    Mice, epididymal white fat
    Outcome group
    Mitochondrial function · Metabolic and weight
    Studied dose
    Dose not stated

    Source sentences

    Summary
    A similar mitochondrial phenotype was detected in epididymal white fat of mice treated with hexarelin
  2. 02AnimalAnimal study (in vivo)Mechanism

    In mice, hexarelin treatment increased expression of thermogenic markers in epididymal white fat.

    In plain wordsIn mice, hexarelin raised markers of heat-producing fat in white fat tissue.

    Peptide
    Hexarelin
    Outcome
    IncreaseThermogenic markers in epididymal white fat of mice
    Study

    mousen: not reported in source

    Mice, epididymal white fat
    Outcome group
    Mitochondrial function · Metabolic and weight
    Studied dose
    Dose not stated

    Source sentences

    Summary
    along with an increased expression of thermogenic markers
  3. 03AnimalAnimal study (in vivo)Mechanism

    In CD36-null mice, the hexarelin-induced increase in thermogenic markers was lost.

    In plain wordsIn mice lacking CD36, hexarelin no longer raised markers of heat-producing fat.

    Peptide
    Hexarelin
    Outcome
    No significant changeThermogenic markers in CD36-null mice
    Study

    mousen: not reported in source

    CD36-null mice
    Outcome group
    Mitochondrial function · Metabolic and weight
    Studied dose
    Dose not stated

    Source sentences

    Summary
    an increased expression of thermogenic markers that was lost in treated CD36-null mice
  4. 04LabIn vitro (cells)Efficacy outcome

    In 3T3-L1 adipocytes, hexarelin treatment depleted intracellular lipid content.

    In plain wordsIn fat cells in a dish, hexarelin lowered the amount of fat stored inside the cells.

    Peptide
    Hexarelin
    Outcome
    DecreaseIntracellular lipid content
    Study

    mousen: not reported in source

    3T3-L1 adipocytes
    Outcome group
    Lipids · Metabolic and weight
    Studied dose
    Dose not stated

    Source sentences

    Summary
    treatment of 3T3-L1 adipocytes with hexarelin, a GH-releasing peptide that interacts with CD36, resulted in a depletion of intracellular lipid content
  5. 05LabIn vitro (cells)Mechanism

    In 3T3-L1 adipocytes, hexarelin treatment caused no significant change in CD36 expression.

    In plain wordsIn fat cells in a dish, hexarelin did not significantly change the amount of the CD36 receptor.

    Peptide
    Hexarelin
    Outcome
    No significant changeCD36 expression
    Study

    mousen: not reported in source

    3T3-L1 adipocytes
    Outcome group
    Receptor activity and mechanism · Metabolic and weight
    Studied dose
    Dose not stated

    Source sentences

    Summary
    treatment of 3T3-L1 adipocytes with hexarelin, a GH-releasing peptide that interacts with CD36, resulted in a depletion of intracellular lipid content with no significant change in CD36 expression.
  6. 06LabIn vitro (cells)Mechanism

    In 3T3-L1 adipocytes, hexarelin increased expression of several genes involved in fatty acid mobilization toward mitochondrial oxidative phosphorylation.

    In plain wordsIn fat cells in a dish, hexarelin turned up genes that move fatty acids toward the cell's energy-making machinery.

    Peptide
    Hexarelin
    Outcome
    IncreaseExpression of genes for fatty acid mobilization to mitochondria
    Study

    mousen: not reported in source

    3T3-L1 adipocytes
    Outcome group
    Mitochondrial function · Metabolic and weight
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Microarray analysis revealed an increased pattern in several genes involved in fatty acid mobilization toward the mitochondrial oxidative phosphorylation process in response to hexarelin.
  7. 07LabIn vitro (cells)Mechanism

    In 3T3-L1 adipocytes, hexarelin up-regulated known PPARgamma targets such as FATP, CPT-1 and F(1)-ATPase.

    In plain wordsIn fat cells in a dish, hexarelin turned up several genes that are known targets of PPARgamma.

    Peptide
    Hexarelin
    Outcome
    IncreasePPARgamma target genes (FATP, CPT-1, F(1)-ATPase)
    Study

    mousen: not reported in source

    3T3-L1 adipocytes
    Outcome group
    Mitochondrial function · Metabolic and weight
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Interestingly, many of these up-regulated genes are known targets of peroxisomal proliferator-activated receptor (PPAR)-gamma, such as FATP, CPT-1, and F(1)-ATPase, suggesting that adipocyte response to hexarelin may involve PPARgamma activation.
  8. 08LabIn vitro (cells)Mechanism

    In 3T3-L1 adipocytes, hexarelin increased expression of the thermogenic markers PPARgamma coactivator 1alpha and uncoupling protein-1.

    In plain wordsIn fat cells in a dish, hexarelin raised markers of heat-producing fat (PGC-1alpha and UCP-1).

    Peptide
    Hexarelin
    Outcome
    IncreaseThermogenic markers PGC-1alpha and UCP-1
    Study

    mousen: not reported in source

    3T3-L1 adipocytes
    Outcome group
    Mitochondrial function · Metabolic and weight
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Expression studies also indicate an increase in thermogenic markers PPARgamma coactivator 1alpha and uncoupling protein-1, which are normally expressed in brown adipocytes.
  9. 09LabIn vitro (cells)Mechanism

    In 3T3-L1 adipocytes, hexarelin treatment produced intense, highly organized mitochondrial cristae compared with untreated cells.

    In plain wordsIn fat cells in a dish, hexarelin changed the inner structure of mitochondria compared with untreated cells.

    Peptide
    Hexarelin
    Outcome
    IncreaseMitochondrial cristae formation (electron microscopy)
    Study

    mousen: not reported in source

    3T3-L1 adipocytes
    Comparator
    Untreated cells
    Outcome group
    Mitochondrial function · Metabolic and weight
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Electron microscopy of hexarelin-treated 3T3-L1 adipocytes showed an intense and highly organized cristae formation that spans the entire width of mitochondria, compared with untreated cells
  10. 10LabIn vitro (cells)Mechanism

    In 3T3-L1 adipocytes, hexarelin enhanced cytochrome c oxidase activity.

    In plain wordsIn fat cells in a dish, hexarelin raised the activity of an enzyme that mitochondria use to make energy.

    Peptide
    Hexarelin
    Outcome
    IncreaseCytochrome c oxidase activity
    Study

    mousen: not reported in source

    3T3-L1 adipocytes
    Outcome group
    Mitochondrial function · Metabolic and weight
    Studied dose
    Dose not stated

    Source sentences

    Summary
    cytochrome c oxidase activity was enhanced by hexarelin, two features characteristic of highly oxidative tissues.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

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