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Study · Randomized controlled trial · n = 30 · 2007

2 results

Oxytocin improves "mind-reading" in humans.

Domes G, Heinrichs M, Michel A, Berger C, Herpertz SC

Biological psychiatry29 Nov 2006Cited by 826 (Europe PMC)

PMID17137561 (opens in a new tab)DOI10.1016/j.biopsych.2006.07.015 (opens in a new tab)PepBankPUB-17137561
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. 2 results from people.

  1. 01HumanRandomized controlled trialEfficacy outcome

    In healthy men, intranasal oxytocin improved performance on the Reading the Mind in the Eyes Test compared with placebo.

    In plain wordsIn healthy men, oxytocin nasal spray improved the reading of other people's feelings from the eyes, compared with placebo.

    Peptide
    Oxytocin
    Outcome
    IncreaseReading the Mind in the Eyes Test performance
    Study

    n = 30

    Comparator
    Placebo
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    24 IU · intranasalAs given in this study (human).

    Source sentences

    Summary
    Oxytocin improved performance on the RMET compared with placebo.
    1 context sentence
    Summary · context
    In a double-blind, placebo-controlled, within-subject design, 30 healthy male volunteers were tested for their ability to infer the affective mental state of others using the Reading the Mind in the Eyes Test (RMET) after intranasal administration of 24 IU oxytocin.
  2. 02HumanRandomized controlled trialEfficacy outcome

    In healthy men, the improvement with intranasal oxytocin over placebo was pronounced for difficult items compared with easy items.

    In plain wordsIn healthy men, oxytocin's gain over placebo in reading feelings from the eyes was larger for difficult items.

    Peptide
    Oxytocin
    Outcome
    IncreaseReading the Mind in the Eyes Test, difficult versus easy items
    Study

    n = 30

    Comparator
    Placebo
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    24 IU · intranasalAs given in this study (human).

    Source sentences

    Summary
    This effect was pronounced for difficult compared with easy items.
    1 context sentence
    Summary · context
    In a double-blind, placebo-controlled, within-subject design, 30 healthy male volunteers were tested for their ability to infer the affective mental state of others using the Reading the Mind in the Eyes Test (RMET) after intranasal administration of 24 IU oxytocin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Registered trials3

Trials this study reports on, or that list this study as a reference. Registry data from ClinicalTrials.gov.

3 trials · 3 completed · 2 with posted results · source ClinicalTrials.gov (opens in a new tab)

CompletedEarly phase 1NCT03211013

Study of the Effects of Oxytocin on Attentional Bias and Startle in PTSD

Palo Alto Veterans Institute for Researchn = 1710 Jul 2017 to 9 Jun 2021

Posttraumatic Stress Disorder

Trial pageClinicalTrials.govUpdated 10 Jun 2021
CompletedPhase 1Results postedNCT01834261

Brain Dynamics of Oxytocin

Stony Brook Universityn = 51Apr 2013 to May 2015

Brain Dynamics in Healthy Adults

Trial pageClinicalTrials.govUpdated 17 Mar 2017
CompletedNot applicableResults postedNCT01312272

Does Acute Oxytocin Administration Enhance Social Cognition in Individuals With Schizophrenia?

VA Greater Los Angeles Healthcare Systemn = 24Apr 2011 to Aug 2012

Schizophrenia

Trial pageClinicalTrials.govUpdated 2 May 2014

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 01:30 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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