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Study · Animal study (in vivo) · rat · 2007

3 results

Intranasal administration with NAD+ profoundly decreases brain injury in a rat model of transient focal ischemia.

Ying W, Wei G, Wang D, Wang Q, Tang X, Shi J, Zhang P, Lu H

Frontiers in bioscience : a journal and virtual library1 Jan 2007Cited by 92 (Europe PMC)

PMID17127275 (opens in a new tab)DOI10.2741/2267 (opens in a new tab)PepBankPUB-17127275
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Pharmacokinetics

    In rats with transient focal ischemia, intranasal NAD+ delivery increased brain NAD+ content.

    In plain wordsIn rats with brain ischemia, intranasal NAD+ increased brain NAD+ levels.

    Peptide
    NAD+ (nicotinamide adenine dinucleotide)
    Outcome
    IncreaseBrain NAD+ content
    Study

    ratn: not reported in source

    Transient focal ischemia
    Outcome group
    Pharmacokinetics · Nervous system and cognition
    Studied dose
    Dose not stated · intranasalAs given in this study (rat).

    Source sentences

    Summary
    We observed that intranasal NAD+ delivery significantly increased NAD+ contents in the brains.
    1 context sentence
    Summary · context
    In this study, we used a rat model of transient focal ischemia to test this hypothesis.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats, intranasal NAD+ given at 2 hours after ischemic onset decreased infarct formation assessed at 24 or 72 hours.

    In plain wordsIn rats, intranasal NAD+ decreased brain infarct formation after ischemia.

    Peptide
    NAD+ (nicotinamide adenine dinucleotide)
    Outcome
    DecreaseInfarct formation
    Study

    ratn: not reported in source

    Transient focal ischemia
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    10 mg/kg · intranasalAs given in this study (rat).

    Source sentences

    Summary
    Intranasal delivery with 10 mg/kg NAD+ at 2 hours after ischemic onset profoundly decreased infarct formation when assessed either at 24 or 72 hours after ischemia.
    1 context sentence
    Summary · context
    In this study, we used a rat model of transient focal ischemia to test this hypothesis.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In rats with transient focal ischemia, NAD+ administration attenuated ischemia-induced neurological deficits.

    In plain wordsIn rats with brain ischemia, NAD+ reduced neurological deficits.

    Peptide
    NAD+ (nicotinamide adenine dinucleotide)
    Outcome
    DecreaseNeurological deficits
    Study

    ratn: not reported in source

    Transient focal ischemia
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated · intranasalAs given in this study (rat).

    Source sentences

    Summary
    The NAD+ administration also significantly attenuated ischemia-induced neurological deficits.
    1 context sentence
    Summary · context
    In this study, we used a rat model of transient focal ischemia to test this hypothesis.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    14 Oct 2026, 05:02 UTC

    Study results updated

  2. Version 1

    14 Oct 2026, 01:46 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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