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Study · Non-randomized trial · n = 6 · 2007

9 results

d-Lys-GHRP-6 does not modify the endocrine response to acylated ghrelin or hexarelin in humans.

Benso A, Prodam F, Lucatello B, Gramaglia E, Riganti F, Schneider H, van der Lely AJ, Muccioli G, Ghigo E, Broglio F

Neuropeptides16 Nov 2006Cited by 6 (Europe PMC)

PMID17112585 (opens in a new tab)DOI10.1016/j.npep.2006.10.001 (opens in a new tab)PepBankPUB-17112585
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study9

4 results from studies that gave the peptide. 4 results from people.

  1. 01HumanNon-randomized trialEfficacy outcome

    In six normal volunteers, hexarelin stimulated GH secretion.

    In plain wordsIn six healthy volunteers, hexarelin raised growth hormone levels.

    Peptide
    Hexarelin
    Outcome
    IncreaseGH secretion after hexarelin
    Study

    n = 6

    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    1.0microg/kg · iv bolusAs given in this study (human).

    Source sentences

    Summary
    Acylated ghrelin and hexarelin stimulated (p<0.05) GH, PRL, ACTH and cortisol secretions.
    1 context sentence
    Summary · context
    The effects of different doses of D-Lys-GHRP-6 (2.0microg/kg iv as bolus or 2.0microg/kg/h iv as infusion) on both spontaneous and acylated ghrelin- or hexarelin (1.0microg/kg iv as bolus) -stimulated GH, PRL, ACTH and cortisol levels were studied in six normal volunteers (age [mean+/-SEM]: 25.4+/-1…
  2. 02HumanNon-randomized trialEfficacy outcome

    In six normal volunteers, hexarelin stimulated prolactin secretion.

    In plain wordsIn six healthy volunteers, hexarelin raised prolactin levels.

    Peptide
    Hexarelin
    Outcome
    IncreasePRL secretion after hexarelin
    Study

    n = 6

    Outcome group
    Pituitary hormones · Endocrine and hormones
    Studied dose
    1.0microg/kg · iv bolusAs given in this study (human).

    Source sentences

    Summary
    Acylated ghrelin and hexarelin stimulated (p<0.05) GH, PRL, ACTH and cortisol secretions.
    1 context sentence
    Summary · context
    The effects of different doses of D-Lys-GHRP-6 (2.0microg/kg iv as bolus or 2.0microg/kg/h iv as infusion) on both spontaneous and acylated ghrelin- or hexarelin (1.0microg/kg iv as bolus) -stimulated GH, PRL, ACTH and cortisol levels were studied in six normal volunteers (age [mean+/-SEM]: 25.4+/-1…
  3. 03HumanNon-randomized trialEfficacy outcome

    In six normal volunteers, hexarelin stimulated ACTH secretion.

    In plain wordsIn six healthy volunteers, hexarelin raised ACTH levels.

    Peptide
    Hexarelin
    Outcome
    IncreaseACTH secretion after hexarelin
    Study

    n = 6

    Outcome group
    Stress hormones · Endocrine and hormones
    Studied dose
    1.0microg/kg · iv bolusAs given in this study (human).

    Source sentences

    Summary
    Acylated ghrelin and hexarelin stimulated (p<0.05) GH, PRL, ACTH and cortisol secretions.
    1 context sentence
    Summary · context
    The effects of different doses of D-Lys-GHRP-6 (2.0microg/kg iv as bolus or 2.0microg/kg/h iv as infusion) on both spontaneous and acylated ghrelin- or hexarelin (1.0microg/kg iv as bolus) -stimulated GH, PRL, ACTH and cortisol levels were studied in six normal volunteers (age [mean+/-SEM]: 25.4+/-1…
  4. 04HumanNon-randomized trialEfficacy outcome

    In six normal volunteers, hexarelin stimulated cortisol secretion.

    In plain wordsIn six healthy volunteers, hexarelin raised cortisol levels.

    Peptide
    Hexarelin
    Outcome
    IncreaseCortisol secretion after hexarelin
    Study

    n = 6

    Outcome group
    Stress hormones · Endocrine and hormones
    Studied dose
    1.0microg/kg · iv bolusAs given in this study (human).

    Source sentences

    Summary
    Acylated ghrelin and hexarelin stimulated (p<0.05) GH, PRL, ACTH and cortisol secretions.
    1 context sentence
    Summary · context
    The effects of different doses of D-Lys-GHRP-6 (2.0microg/kg iv as bolus or 2.0microg/kg/h iv as infusion) on both spontaneous and acylated ghrelin- or hexarelin (1.0microg/kg iv as bolus) -stimulated GH, PRL, ACTH and cortisol levels were studied in six normal volunteers (age [mean+/-SEM]: 25.4+/-1…

Studies that did not test the peptide alone5

In this study, the peptide was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking the peptide.

  1. 05HumanNot a test of Hexarelin aloneNon-randomized trialEfficacy outcome

    In six normal volunteers, D-Lys-GHRP-6 did not modify the GH response stimulated by hexarelin.

    In plain wordsIn six healthy volunteers, D-Lys-GHRP-6 did not change the growth hormone rise caused by hexarelin.

    Peptide
    Hexarelin
    Outcome
    No significant changeEffect of D-Lys-GHRP-6 on hexarelin-stimulated GH
    Study

    n = 6

    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones

    Source sentences

    Summary
    D-Lys-GHRP-6 administered either as bolus or a continuous infusion did not modify both spontaneous and acylated ghrelin- or hexarelin-stimulated GH, PRL, ACTH and cortisol secretion.
    1 context sentence
    Summary · context
    The effects of different doses of D-Lys-GHRP-6 (2.0microg/kg iv as bolus or 2.0microg/kg/h iv as infusion) on both spontaneous and acylated ghrelin- or hexarelin (1.0microg/kg iv as bolus) -stimulated GH, PRL, ACTH and cortisol levels were studied in six normal volunteers (age [mean+/-SEM]: 25.4+/-1…

    In this study, Hexarelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Hexarelin.

  2. 06HumanNot a test of Hexarelin aloneNon-randomized trialEfficacy outcome

    In six normal volunteers, D-Lys-GHRP-6 did not modify the prolactin response stimulated by hexarelin.

    In plain wordsIn six healthy volunteers, D-Lys-GHRP-6 did not change the prolactin rise caused by hexarelin.

    Peptide
    Hexarelin
    Outcome
    No significant changeEffect of D-Lys-GHRP-6 on hexarelin-stimulated PRL
    Study

    n = 6

    Outcome group
    Pituitary hormones · Endocrine and hormones

    Source sentences

    Summary
    D-Lys-GHRP-6 administered either as bolus or a continuous infusion did not modify both spontaneous and acylated ghrelin- or hexarelin-stimulated GH, PRL, ACTH and cortisol secretion.
    1 context sentence
    Summary · context
    The effects of different doses of D-Lys-GHRP-6 (2.0microg/kg iv as bolus or 2.0microg/kg/h iv as infusion) on both spontaneous and acylated ghrelin- or hexarelin (1.0microg/kg iv as bolus) -stimulated GH, PRL, ACTH and cortisol levels were studied in six normal volunteers (age [mean+/-SEM]: 25.4+/-1…

    In this study, Hexarelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Hexarelin.

  3. 07HumanNot a test of Hexarelin aloneNon-randomized trialEfficacy outcome

    In six normal volunteers, D-Lys-GHRP-6 did not modify the ACTH response stimulated by hexarelin.

    In plain wordsIn six healthy volunteers, D-Lys-GHRP-6 did not change the ACTH rise caused by hexarelin.

    Peptide
    Hexarelin
    Outcome
    No significant changeEffect of D-Lys-GHRP-6 on hexarelin-stimulated ACTH
    Study

    n = 6

    Outcome group
    Stress hormones · Endocrine and hormones

    Source sentences

    Summary
    D-Lys-GHRP-6 administered either as bolus or a continuous infusion did not modify both spontaneous and acylated ghrelin- or hexarelin-stimulated GH, PRL, ACTH and cortisol secretion.
    1 context sentence
    Summary · context
    The effects of different doses of D-Lys-GHRP-6 (2.0microg/kg iv as bolus or 2.0microg/kg/h iv as infusion) on both spontaneous and acylated ghrelin- or hexarelin (1.0microg/kg iv as bolus) -stimulated GH, PRL, ACTH and cortisol levels were studied in six normal volunteers (age [mean+/-SEM]: 25.4+/-1…

    In this study, Hexarelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Hexarelin.

  4. 08HumanNot a test of Hexarelin aloneNon-randomized trialEfficacy outcome

    In six normal volunteers, D-Lys-GHRP-6 did not modify the cortisol response stimulated by hexarelin.

    In plain wordsIn six healthy volunteers, D-Lys-GHRP-6 did not change the cortisol rise caused by hexarelin.

    Peptide
    Hexarelin
    Outcome
    No significant changeEffect of D-Lys-GHRP-6 on hexarelin-stimulated cortisol
    Study

    n = 6

    Outcome group
    Stress hormones · Endocrine and hormones

    Source sentences

    Summary
    D-Lys-GHRP-6 administered either as bolus or a continuous infusion did not modify both spontaneous and acylated ghrelin- or hexarelin-stimulated GH, PRL, ACTH and cortisol secretion.
    1 context sentence
    Summary · context
    The effects of different doses of D-Lys-GHRP-6 (2.0microg/kg iv as bolus or 2.0microg/kg/h iv as infusion) on both spontaneous and acylated ghrelin- or hexarelin (1.0microg/kg iv as bolus) -stimulated GH, PRL, ACTH and cortisol levels were studied in six normal volunteers (age [mean+/-SEM]: 25.4+/-1…

    In this study, Hexarelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Hexarelin.

  5. 09HumanNot a test of GHRP-6 aloneNon-randomized trialEfficacy outcome

    In six normal volunteers, the GHRP‑6 analog D-Lys-GHRP‑6 did not modify spontaneous or ghrelin- or hexarelin-stimulated GH, PRL, ACTH and cortisol secretion.

    In plain wordsIn six healthy volunteers, the GHRP‑6 analog D-Lys-GHRP‑6 did not change hormone rises caused by ghrelin or hexarelin.

    Peptide
    GHRP-6
    Outcome
    No significant changeEffect of D-Lys-GHRP-6 on stimulated GH, PRL, ACTH and cortisol
    Study

    n = 6

    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones

    Source sentences

    Summary
    D-Lys-GHRP-6 administered either as bolus or a continuous infusion did not modify both spontaneous and acylated ghrelin- or hexarelin-stimulated GH, PRL, ACTH and cortisol secretion.
    1 context sentence
    Summary · context
    The effects of different doses of D-Lys-GHRP-6 (2.0microg/kg iv as bolus or 2.0microg/kg/h iv as infusion) on both spontaneous and acylated ghrelin- or hexarelin (1.0microg/kg iv as bolus) -stimulated GH, PRL, ACTH and cortisol levels were studied in six normal volunteers (age [mean+/-SEM]: 25.4+/-1…

    In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 2

    13 Oct 2026, 16:31 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 03:13 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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