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Study · Ex vivo tissue · 2007

5 results

Thymosin beta4 induces adult epicardial progenitor mobilization and neovascularization.

Smart N, Risebro CA, Melville AA, Moses K, Schwartz RJ, Chien KR, Riley PR

Nature15 Nov 2006Cited by 510 (Europe PMC)

PMID17108969 (opens in a new tab)DOI10.1038/nature05383 (opens in a new tab)PepBankPUB-17108969
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabEx vivo tissueEfficacy outcome

    Thymosin beta4 stimulated significant outgrowth from quiescent adult epicardial explants.

    In plain wordsIn lab tests, thymosin beta4 stimulated significant outgrowth from resting adult heart-surface tissue samples.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseOutgrowth from adult epicardial explants
    Study

    n: not reported in source

    Adult epicardial explants
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Tbeta4 stimulates significant outgrowth from quiescent adult epicardial explants
  2. 02LabEx vivo tissueMechanism

    In adult epicardial explants, thymosin beta4 restored pluripotency.

    In plain wordsIn lab tests, thymosin beta4 restored the ability of adult heart-surface cells to become many cell types.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseRestoration of pluripotency in adult epicardial explants
    Study

    n: not reported in source

    Adult epicardial explants
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    restoring pluripotency
  3. 03LabEx vivo tissueMechanism

    In adult epicardial explants, thymosin beta4 triggered differentiation of fibroblasts, smooth muscle cells and endothelial cells.

    In plain wordsIn lab tests, thymosin beta4 triggered adult heart-surface cells to become fibroblasts, smooth muscle cells and endothelial cells.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseDifferentiation into fibroblasts, smooth muscle cells and endothelial cells
    Study

    n: not reported in source

    Adult epicardial explants
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    triggering differentiation of fibroblasts, smooth muscle cells and endothelial cells.

Studies that did not test the peptide alone2

In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Thymosin beta-4 (human).

  1. 04AnimalNot a test of Thymosin beta-4 (human) aloneAnimal study (in vivo)Mechanism

    In mice, thymosin beta4 was essential for all aspects of coronary vessel development.

    In plain wordsIn mice, thymosin beta4 was needed for all aspects of coronary blood vessel development.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    Not applicableCoronary vessel development in Tbeta4 mutant mice
    Study

    mousen: not reported in source

    Outcome group
    Heart function · Cardiovascular

    Source sentences

    Summary
    Here we identify thymosin beta4 (Tbeta4) as essential for all aspects of coronary vessel development in mice

    In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).

  2. 05AnimalNot a test of Thymosin beta-4 (human) aloneAnimal study (in vivo)Mechanism

    In the heart, thymosin beta4 knockdown was accompanied by a significant reduction in its cleavage product AcSDKP.

    In plain wordsIn animals, lowering thymosin beta4 in the heart came with much less of its breakdown product AcSDKP.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    DecreaseAcSDKP level after Tbeta4 knockdown in the heart
    Study

    n: not reported in source

    Outcome group
    Heart function · Cardiovascular

    Source sentences

    Summary
    Tbeta4 knockdown in the heart is accompanied by significant reduction in the pro-angiogenic cleavage product N-acetyl-seryl-aspartyl-lysyl-proline (AcSDKP).

    In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 01:52 UTC

    Study results updated

  2. Version 1

    12 Oct 2026, 18:17 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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