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Study · Animal study (in vivo) · rat · 2006

5 results

Zinc L-carnosine protects against mucosal injury in portal hypertensive gastropathy through induction of heat shock protein 72.

Mikami K, Otaka M, Watanabe D, Goto T, Endoh A, Miura K, Ohshima S, Yoneyama K, Sato M, Shibuya T, Segawa D, Kataoka E and 5 more

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Yoshino R, Takeuchi S, Sato W, Odashima M, Watanabe S

Journal of gastroenterology and hepatology1 Nov 2006Cited by 22 (Europe PMC)

PMID16984587 (opens in a new tab)DOI10.1111/j.1440-1746.2006.04328.x (opens in a new tab)PepBankPUB-16984587
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In rats with bile duct ligation, L‑carnosine induced gastric mucosal hsp72.

    In plain wordsIn rats with bile duct ligation, L‑carnosine increased gastric mucosal hsp72.

    Peptide
    L-carnosine
    Outcome
    IncreaseGastric hsp72 expression
    Study

    ratn: not reported in source

    bile duct ligation-induced portal hypertensive gastropathy
    Outcome group
    Receptor activity and mechanism · Gastrointestinal
    Studied dose
    Dose not stated · intragastricAs given in this study (rat).

    Source sentences

    Summary
    L-carnosine, zinc sulfate, and zinc L-carnosine induced hsp72 in gastric mucosa of rats with bile duct ligation.
    2 context sentences
    Summary · context
    Portal hypertensive gastropathy with liver cirrhosis was induced by bile duct ligation for 4 weeks in male Sprague-Dawley rats.
    Summary · context
    Expression of gastric mucosal hsp72 was evaluated by Western blotting at 6 h after intragastric administration of L-carnosine, zinc sulfate, or zinc L-carnosine.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats with bile duct ligation, L‑carnosine did not suppress HCl-induced gastric mucosal injury.

    In plain wordsIn rats with bile duct ligation, L‑carnosine did not suppress acid-induced stomach lining injury.

    Peptide
    L-carnosine
    Outcome
    No significant changeHCl-induced mucosal injury
    Study

    ratn: not reported in source

    bile duct ligation-induced portal hypertensive gastropathy
    Outcome group
    Gastrointestinal protection · Gastrointestinal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    However, L-carnosine could not suppress HCl-induced mucosal injury.
    2 context sentences
    Summary · context
    Portal hypertensive gastropathy with liver cirrhosis was induced by bile duct ligation for 4 weeks in male Sprague-Dawley rats.
    Summary · context
    Expression of gastric mucosal hsp72 was evaluated by Western blotting at 6 h after intragastric administration of L-carnosine, zinc sulfate, or zinc L-carnosine.

Studies that did not test the peptide alone3

In this study, L-carnosine was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking L-carnosine.

  1. 03AnimalNot a test of L-carnosine aloneAnimal study (in vivo)Mechanism

    In rats with bile duct ligation, zinc L‑carnosine induced gastric mucosal hsp72 in a dose-dependent manner.

    In plain wordsIn rats with bile duct ligation, zinc L‑carnosine increased gastric mucosal hsp72 with increasing doses.

    Peptide
    L-carnosine
    Outcome
    IncreaseGastric hsp72 expression
    Study

    ratn: not reported in source

    bile duct ligation-induced portal hypertensive gastropathy
    Outcome group
    Receptor activity and mechanism · Gastrointestinal

    Source sentences

    Summary
    Furthermore, pretreatment with zinc L-carnosine (30-300 mg/kg) increased the expression of hsp72 in gastric mucosa and prevented HCl-induced mucosal injury in rats with bile duct ligation in a dose-dependent manner.
    2 context sentences
    Summary · context
    Portal hypertensive gastropathy with liver cirrhosis was induced by bile duct ligation for 4 weeks in male Sprague-Dawley rats.
    Summary · context
    Expression of gastric mucosal hsp72 was evaluated by Western blotting at 6 h after intragastric administration of L-carnosine, zinc sulfate, or zinc L-carnosine.

    In this study, L-carnosine was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking L-carnosine.

  2. 04AnimalNot a test of L-carnosine aloneAnimal study (in vivo)Efficacy outcome

    In rats with bile duct ligation, zinc L‑carnosine prevented HCl-induced gastric mucosal injury in a dose-dependent manner.

    In plain wordsIn rats with bile duct ligation, zinc L‑carnosine prevented acid-induced stomach lining injury with increasing doses.

    Peptide
    L-carnosine
    Outcome
    DecreaseHCl-induced mucosal injury
    Study

    ratn: not reported in source

    bile duct ligation-induced portal hypertensive gastropathy
    Outcome group
    Gastrointestinal protection · Gastrointestinal

    Source sentences

    Summary
    Furthermore, pretreatment with zinc L-carnosine (30-300 mg/kg) increased the expression of hsp72 in gastric mucosa and prevented HCl-induced mucosal injury in rats with bile duct ligation in a dose-dependent manner.
    2 context sentences
    Summary · context
    Portal hypertensive gastropathy with liver cirrhosis was induced by bile duct ligation for 4 weeks in male Sprague-Dawley rats.
    Summary · context
    Expression of gastric mucosal hsp72 was evaluated by Western blotting at 6 h after intragastric administration of L-carnosine, zinc sulfate, or zinc L-carnosine.

    In this study, L-carnosine was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking L-carnosine.

  3. 05AnimalNot a test of L-carnosine aloneAnimal study (in vivo)Pharmacokinetics

    In rats with bile duct ligation, serum zinc significantly increased after zinc L‑carnosine administration.

    In plain wordsIn rats with bile duct ligation, blood zinc significantly increased after zinc L‑carnosine administration.

    Peptide
    L-carnosine
    Outcome
    IncreaseSerum zinc
    Study

    ratn: not reported in source

    bile duct ligation-induced portal hypertensive gastropathy
    Outcome group
    Pharmacokinetics · Pharmacology

    Source sentences

    Summary
    Serum zinc levels were significantly elevated after zinc L-carnosine administration.
    2 context sentences
    Summary · context
    Portal hypertensive gastropathy with liver cirrhosis was induced by bile duct ligation for 4 weeks in male Sprague-Dawley rats.
    Summary · context
    Expression of gastric mucosal hsp72 was evaluated by Western blotting at 6 h after intragastric administration of L-carnosine, zinc sulfate, or zinc L-carnosine.

    In this study, L-carnosine was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking L-carnosine.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    27 Oct 2026, 18:20 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:32 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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