Skip to content

Study · Animal study (in vivo) · mouse · 2006

9 results

Humanin is a novel neuroprotective agent against stroke.

Xu X, Chua CC, Gao J, Hamdy RC, Chua BH

Stroke7 Sept 2006Cited by 154 (Europe PMC)

PMID16960089 (opens in a new tab)DOI10.1161/01.str.0000242772.94277.1f (opens in a new tab)PepBankPUB-16960089
Publisher pagePubMedAsk about this study
Jump to 9 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study9

9 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In mice with middle cerebral artery occlusion, HNG pretreatment (0.1 microg, intracerebroventricular) reduced cerebral infarct volume from 56.2% to 26.1%.

    In plain wordsIn mice with induced stroke, HNG given before the stroke reduced the size of the brain damage.

    Peptide
    Humanin
    Outcome
    DecreaseCerebral infarct volume, pretreatment 0.1 microg intracerebroventricular
    Study

    mousen: not reported in source

    middle cerebral artery occlusion with reperfusion
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    0.1 microg · intracerebroventricularAs given in this study (mouse).

    Measurements

    Infarct volume
    56.2%
    comparison group (not named)
    Infarct volume
    26.1%
    HNG 0.1 microg pretreatment

    Source sentences

    Summary
    Pretreatment with 0.1 microg HNG (intracerebroventricularly) 30 minutes before ischemia reduced cerebral infarct volume from 56.2+/-3.0% to 26.1+/-1.4% (P<0.01).
    1 context sentence
    Summary · context
    Mice underwent middle cerebral artery occlusion for 75 minutes followed by 24-hour reperfusion.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In mice with middle cerebral artery occlusion, HNG posttreatment after 4 hours of reperfusion reduced cerebral infarct volume to 45.6%.

    In plain wordsIn mice with induced stroke, HNG given 4 hours after the stroke reduced the size of the brain damage.

    Peptide
    Humanin
    Outcome
    DecreaseCerebral infarct volume, posttreatment after 4 hours of reperfusion
    Study

    mousen: not reported in source

    middle cerebral artery occlusion with reperfusion
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    0.1 microg · intracerebroventricularAs given in this study (mouse).

    Measurements

    Infarct volume
    45.6%
    HNG posttreatment after 4 hours of reperfusion

    Source sentences

    Summary
    HNG posttreatment after 4 hours of reperfusion reduced cerebral infarct volume to 45.6+/-2.6% (P<0.05).
    1 context sentence
    Summary · context
    Mice underwent middle cerebral artery occlusion for 75 minutes followed by 24-hour reperfusion.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In mice with middle cerebral artery occlusion, intraperitoneal HNG pretreatment (1 microg) 1 hour before ischemia significantly reduced cerebral infarct volume.

    In plain wordsIn mice with induced stroke, HNG injected into the abdomen before the stroke reduced the size of the brain damage.

    Peptide
    Humanin
    Outcome
    DecreaseCerebral infarct volume, intraperitoneal pretreatment 1 microg
    Study

    mousen: not reported in source

    middle cerebral artery occlusion with reperfusion
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    1 microg · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    Pretreatment with 1 microg HNG (intraperitoneally) 1 hour before ischemia
    2 context sentences
    Summary · context
    reduced cerebral infarct volume significantly.
    Summary · context
    Mice underwent middle cerebral artery occlusion for 75 minutes followed by 24-hour reperfusion.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In mice with middle cerebral artery occlusion, HNG posttreatment after 2 hours of reperfusion significantly reduced cerebral infarct volume.

    In plain wordsIn mice with induced stroke, HNG given 2 hours after the stroke reduced the size of the brain damage.

    Peptide
    Humanin
    Outcome
    DecreaseCerebral infarct volume, posttreatment after 2 hours of reperfusion
    Study

    mousen: not reported in source

    middle cerebral artery occlusion with reperfusion
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated · intracerebroventricularAs given in this study (mouse).

    Source sentences

    Summary
    Pretreatment with 1 microg HNG (intraperitoneally) 1 hour before ischemia or posttreatment after 2 hours of reperfusion reduced cerebral infarct volume significantly.
    1 context sentence
    Summary · context
    Mice underwent middle cerebral artery occlusion for 75 minutes followed by 24-hour reperfusion.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In mice with middle cerebral artery occlusion, HNG significantly improved neurological function.

    In plain wordsIn mice with induced stroke, HNG improved nerve function.

    Peptide
    Humanin
    Outcome
    IncreaseNeurological function
    Study

    mousen: not reported in source

    middle cerebral artery occlusion with reperfusion
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    HNG also significantly improved neurological function and inhibited both neuronal apoptosis as well as poly(ADP-ribose) polymerase activation.
    1 context sentence
    Summary · context
    Mice underwent middle cerebral artery occlusion for 75 minutes followed by 24-hour reperfusion.
  6. 06AnimalAnimal study (in vivo)Mechanism

    In mice with middle cerebral artery occlusion, HNG significantly inhibited neuronal apoptosis.

    In plain wordsIn mice with induced stroke, HNG reduced the death of nerve cells.

    Peptide
    Humanin
    Outcome
    DecreaseNeuronal apoptosis (TUNEL)
    Study

    mousen: not reported in source

    middle cerebral artery occlusion with reperfusion
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    HNG also significantly improved neurological function and inhibited both neuronal apoptosis as well as poly(ADP-ribose) polymerase activation.
    1 context sentence
    Summary · context
    Mice underwent middle cerebral artery occlusion for 75 minutes followed by 24-hour reperfusion.
  7. 07AnimalAnimal study (in vivo)Mechanism

    In mice with middle cerebral artery occlusion, HNG significantly inhibited poly(ADP-ribose) polymerase activation.

    In plain wordsIn mice with induced stroke, HNG reduced activation of a cell-death enzyme.

    Peptide
    Humanin
    Outcome
    DecreasePoly(ADP-ribose) polymerase activation
    Study

    mousen: not reported in source

    middle cerebral artery occlusion with reperfusion
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    HNG also significantly improved neurological function and inhibited both neuronal apoptosis as well as poly(ADP-ribose) polymerase activation.
    1 context sentence
    Summary · context
    Mice underwent middle cerebral artery occlusion for 75 minutes followed by 24-hour reperfusion.
  8. 08AnimalAnimal study (in vivo)Mechanism

    In mice with middle cerebral artery occlusion, HNG treatment significantly decreased phospho-ERK.

    In plain wordsIn mice with induced stroke, HNG lowered the level of active ERK, a cell signal protein.

    Peptide
    Humanin
    Outcome
    DecreasePhospho-ERK level
    Study

    mousen: not reported in source

    middle cerebral artery occlusion with reperfusion
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    A significant decrease of phospho-ERK was observed in mice treated with HNG
    1 context sentence
    Summary · context
    Mice underwent middle cerebral artery occlusion for 75 minutes followed by 24-hour reperfusion.
  9. 09AnimalAnimal study (in vivo)Mechanism

    In mice with middle cerebral artery occlusion, HNG treatment did not alter phospho-JNK or phospho-p38 levels.

    In plain wordsIn mice with induced stroke, HNG did not change the levels of two other cell signal proteins, JNK and p38.

    Peptide
    Humanin
    Outcome
    No significant changePhospho-JNK and phospho-p38 levels
    Study

    mousen: not reported in source

    middle cerebral artery occlusion with reperfusion
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    whereas phospho-JNK and phospho-p38 levels were not altered.
    1 context sentence
    Summary · context
    Mice underwent middle cerebral artery occlusion for 75 minutes followed by 24-hour reperfusion.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.