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Study · Measured the body's own peptide · 2006

5 results

Postnatal development of kisspeptin neurons in mouse hypothalamus; sexual dimorphism and projections to gonadotropin-releasing hormone neurons.

Clarkson J, Herbison AE

Endocrinology7 Sept 2006Cited by 646 (Europe PMC)

PMID16959837 (opens in a new tab)PMCIDPMC6098691 (opens in a new tab)DOI10.1210/en.2006-0787 (opens in a new tab)PepBankPUB-16959837
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

No result from this study comes from a test of the peptide.

Natural levels measured5

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01AnimalEndogenous levelAnimal study (in vivo)Other

    In mice, three populations of kisspeptin neurons were identified in the AVPV/PeN, dorsomedial hypothalamus and arcuate nucleus.

    In plain wordsIn mice, the body's own kisspeptin is made by brain cells in three regions.

    Peptide
    Kisspeptin-10
    Outcome
    Not applicableKisspeptin neuron populations in mouse hypothalamus
    Study

    mousen: not reported in source

    Mouse hypothalamus, postnatal development
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health

    Source sentences

    Summary
    Three populations of kisspeptin neurons located in the 1) anteroventral periventricular nucleus (AVPV) and the preoptic periventricular nucleus (PeN), 2) dorsomedial hypothalamus, and 3) arcuate nucleus were identified using an antisera raised against mouse kisspeptin-10.
    1 context sentence
    Summary · context
    We examined here the postnatal development of kisspeptin neuronal populations and their projections to GnRH neurons in the mouse.

    This result measures the body's own Kisspeptin-10. Nobody was given the peptide. It is not evidence about taking it.

  2. 02AnimalEndogenous levelAnimal study (in vivo)Other

    In mice, the AVPV/PeN had about 10-fold more kisspeptin neurons in females than in males (P<0.01), with no sex difference elsewhere.

    In plain wordsIn mice, females had about ten times more of the body's own kisspeptin-making brain cells than males in one region.

    Peptide
    Kisspeptin-10
    Outcome
    IncreaseKisspeptin neuron numbers in AVPV/PeN, female versus male
    Study

    mousen: not reported in source

    Mouse hypothalamus, postnatal development
    Comparator
    Males
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health

    Measurements

    Sex difference in neuron number
    10 fold
    AVPV/PeN, female versus male

    Source sentences

    Summary
    A marked 10-fold (P<0.01), female-dominant sex difference in the numbers of kisspeptin neurons existed in the AVPV/PeN but not elsewhere.
    1 context sentence
    Summary · context
    We examined here the postnatal development of kisspeptin neuronal populations and their projections to GnRH neurons in the mouse.

    This result measures the body's own Kisspeptin-10. Nobody was given the peptide. It is not evidence about taking it.

  3. 03AnimalEndogenous levelAnimal study (in vivo)Other

    In mice of both sexes, AVPV/PeN kisspeptin neurons were absent at postnatal day 10 and increased from day 25 to adult levels by puberty onset (P<0.01).

    In plain wordsIn mice, the body's own kisspeptin-making brain cells appeared after day 10 and reached adult numbers by puberty.

    Peptide
    Kisspeptin-10
    Outcome
    IncreaseKisspeptin neuron numbers in AVPV/PeN across postnatal development
    Study

    mousen: not reported in source

    Mouse hypothalamus, postnatal development
    Comparator
    Postnatal day 10
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health

    Source sentences

    Summary
    Kisspeptin neurons in the AVPV/PeN of both sexes displayed a similar pattern of postnatal development with no cells detected at postnatal day (P) 10, followed by increases from P25 to reach adult levels by puberty onset (P<0.01; P31 females and P45 males).
    1 context sentence
    Summary · context
    We examined here the postnatal development of kisspeptin neuronal populations and their projections to GnRH neurons in the mouse.

    This result measures the body's own Kisspeptin-10. Nobody was given the peptide. It is not evidence about taking it.

  4. 04AnimalEndogenous levelAnimal study (in vivo)Other

    In mice, the postnatal increase of kisspeptin neurons seen in the AVPV/PeN was not found in the dorsomedial hypothalamus or arcuate nucleus.

    In plain wordsIn mice, this rise in the body's own kisspeptin-making cells did not occur in two other brain regions.

    Peptide
    Kisspeptin-10
    Outcome
    No significant changeKisspeptin neuron development in dorsomedial hypothalamus and arcuate nucleus
    Study

    mousen: not reported in source

    Mouse hypothalamus, postnatal development
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health

    Source sentences

    Summary
    This pattern was not found in the dorsomedial hypothalamus or arcuate nucleus.
    1 context sentence
    Summary · context
    We examined here the postnatal development of kisspeptin neuronal populations and their projections to GnRH neurons in the mouse.

    This result measures the body's own Kisspeptin-10. Nobody was given the peptide. It is not evidence about taking it.

  5. 05AnimalEndogenous levelAnimal study (in vivo)Other

    In mice of both sexes, close appositions between kisspeptin fibers and GnRH neuron cell bodies were first apparent at postnatal day 25 and increased across postnatal development.

    In plain wordsIn mice, the body's own kisspeptin nerve fibers moved closer to GnRH cells from day 25 and kept increasing with age.

    Peptide
    Kisspeptin-10
    Outcome
    IncreaseKisspeptin fiber appositions with GnRH neuron cell bodies
    Study

    mousen: not reported in source

    Mouse hypothalamus, postnatal development
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health

    Source sentences

    Summary
    Dual immunofluorescence experiments demonstrated close appositions between kisspeptin fibers and GnRH neuron cell bodies that were first apparent at P25 and increased across postnatal development in both sexes.
    1 context sentence
    Summary · context
    We examined here the postnatal development of kisspeptin neuronal populations and their projections to GnRH neurons in the mouse.

    This result measures the body's own Kisspeptin-10. Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 09:43 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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