Kisspeptin mediates the photoperiodic control of reproduction in hamsters.

Revel FG, Saboureau M, Masson-Pévet M, Pévet P, Mikkelsen JD, Simonneaux V

Current biology : CB1 Sept 2006Cited by 198 (Europe PMC)

PMID16950111DOI10.1016/j.cub.2006.07.025PepBankPUB-16950111

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

1 result from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In short-day Syrian hamsters, chronic kisspeptin‑10 administration restored testicular activity despite photoinhibitory conditions.
In plain wordsIn hamsters kept in short days, long-term kisspeptin‑10 brought back testis activity.
Peptide
Kisspeptin-10
Outcome
IncreaseTesticular activity in short-day hamsters
Study
Syrian hamstern: not reported in source
Syrian hamster, long or short photoperiod
Comparator
Short-day hamsters without kisspeptin-10
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
Dose not stated · chronic administrationAs given in this study (Syrian hamster).
Source sentences
Summary
Remarkably, a chronic administration of kisspeptin-10 restored the testicular activity of SD hamsters despite persisting photoinhibitory conditions.
1 context sentence(design, population, supporting numbers)
Summary · context
The Syrian hamster is a seasonal model in which reproductive activity is promoted by long summer days (LD) and inhibited by short winter days (SD).
Report a problemFND-1695011106

Natural levels measured5

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

02AnimalEndogenous levelAnimal study (in vivo)Mechanism
In long-day Syrian hamsters, KiSS-1 was expressed in the arcuate nucleus.
In plain wordsIn hamsters, the body's own kisspeptin gene is active in a brain region.
Peptide
Kisspeptin-10
Outcome
Not applicableKiSS-1 expression in arcuate nucleus of long-day hamsters
Study
Syrian hamstern: not reported in source
Syrian hamster, long or short photoperiod
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Source sentences
Summary
Using in situ hybridization and immunohistochemistry, we show that KiSS-1 is expressed in the arcuate nucleus of LD hamsters.
1 context sentence(design, population, supporting numbers)
Summary · context
The Syrian hamster is a seasonal model in which reproductive activity is promoted by long summer days (LD) and inhibited by short winter days (SD).
This result measures the body's own Kisspeptin-10. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-1695011101
03AnimalEndogenous levelAnimal study (in vivo)Mechanism
In Syrian hamsters, KiSS-1 mRNA level was lower in short-day animals.
In plain wordsIn hamsters, the body's own kisspeptin gene was less active on short winter days.
Peptide
Kisspeptin-10
Outcome
DecreaseKiSS-1 mRNA in short-day versus long-day hamsters
Study
Syrian hamstern: not reported in source
Syrian hamster, long or short photoperiod
Comparator
Long days
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Source sentences
Summary
Importantly, the KiSS-1 mRNA level was lower in SD animals
1 context sentence(design, population, supporting numbers)
Summary · context
The Syrian hamster is a seasonal model in which reproductive activity is promoted by long summer days (LD) and inhibited by short winter days (SD).
This result measures the body's own Kisspeptin-10. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-1695011102
04AnimalEndogenous levelAnimal study (in vivo)Mechanism
In Syrian hamsters that were refractory to short days, KiSS-1 mRNA was not lower.
In plain wordsIn hamsters that recovered from short days, the body's own kisspeptin gene stayed active.
Peptide
Kisspeptin-10
Outcome
No significant changeKiSS-1 mRNA in short-day-refractory hamsters
Study
Syrian hamstern: not reported in source
Syrian hamster, long or short photoperiod
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Source sentences
Summary
Importantly, the KiSS-1 mRNA level was lower in SD animals but not in SD-refractory animals, which spontaneously reactivated their sexual activity after several months in SD.
1 context sentence(design, population, supporting numbers)
Summary · context
The Syrian hamster is a seasonal model in which reproductive activity is promoted by long summer days (LD) and inhibited by short winter days (SD).
This result measures the body's own Kisspeptin-10. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-1695011103
05AnimalEndogenous levelAnimal study (in vivo)Mechanism
In Syrian hamsters, the seasonal changes of KiSS-1 expression were not secondary to photoperiodic variations of gonadal steroids.
In plain wordsIn hamsters, seasonal changes in the body's own kisspeptin gene were not caused by sex hormone changes.
Peptide
Kisspeptin-10
Outcome
Not applicableKiSS-1 expression changes and gonadal steroids
Study
Syrian hamstern: not reported in source
Syrian hamster, long or short photoperiod
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Source sentences
Summary
These changes of expression are not secondary to the photoperiodic variations of gonadal steroids.
1 context sentence(design, population, supporting numbers)
Summary · context
The Syrian hamster is a seasonal model in which reproductive activity is promoted by long summer days (LD) and inhibited by short winter days (SD).
This result measures the body's own Kisspeptin-10. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-1695011104
06AnimalEndogenous levelAnimal study (in vivo)Mechanism
In short-day Syrian hamsters, pineal-gland ablation prevented the downregulation of KiSS-1 expression.
In plain wordsIn hamsters, removing the pineal gland stopped the short-day drop in the body's own kisspeptin gene activity.
Peptide
Kisspeptin-10
Outcome
No significant changeKiSS-1 downregulation after pineal-gland ablation
Study
Syrian hamstern: not reported in source
Syrian hamster, long or short photoperiod
Comparator
Intact short-day hamsters
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Source sentences
Summary
In contrast, melatonin appears to be necessary for these seasonal changes because pineal-gland ablation prevented the SD-induced downregulation of KiSS-1 expression.
1 context sentence(design, population, supporting numbers)
Summary · context
The Syrian hamster is a seasonal model in which reproductive activity is promoted by long summer days (LD) and inhibited by short winter days (SD).
This result measures the body's own Kisspeptin-10. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-1695011105

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
10 Oct 2026, 09:43 UTC
Study results updated
Version 1
9 Oct 2026, 03:04 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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MeSH terms

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