Ontogeny and mechanisms of action for the stimulatory effect of kisspeptin on gonadotropin-releasing hormone system of the rat.

Castellano JM, Navarro VM, Fernández-Fernández R, Castaño JP, Malagón MM, Aguilar E, Dieguez C, Magni P, Pinilla L, Tena-Sempere M

Molecular and cellular endocrinology22 Aug 2006Cited by 117 (Europe PMC)

PMID16930819DOI10.1016/j.mce.2006.07.002PepBankPUB-16930819

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

7 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In sexually immature rats, kisspeptin‑10 potently elicited LH secretion in vivo from neonatal to juvenile stages.
In plain wordsIn young rats, kisspeptin‑10 strongly raised LH release.
Peptide
Kisspeptin-10
Outcome
IncreaseLH secretion in vivo in early postnatal rats
Study
ratn: not reported in source
Rat
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
Dose not stated
Source sentences
Summary
Despite sexual immaturity, kisspeptin-10 potently elicited GnRH release ex vivo and LH secretion in vivo at early stages (neonatal to juvenile) of postnatal development.
1 context sentence(design, population, supporting numbers)
Summary · context
To cover these issues, the effects of kisspeptin-10 on GnRH and LH secretion were monitored at early stages of postnatal maturation, and potential changes in the sensitivity to kisspeptin were assessed along the pubertal transition in the rat.
Report a problemFND-1693081902
02AnimalAnimal study (in vivo)Efficacy outcome
In peri-pubertal rats, LH responsiveness to low doses of kisspeptin was enhanced.
In plain wordsIn rats near puberty, small doses of kisspeptin raised LH more strongly.
Peptide
Kisspeptin-10
Outcome
IncreaseLH responsiveness to low kisspeptin doses in peri-pubertal rats
Study
ratn: not reported in source
Rat
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
Dose not stated
Source sentences
Summary
Yet, LH responsiveness to low doses of kisspeptin was enhanced in peri-pubertal animals.
1 context sentence(design, population, supporting numbers)
Summary · context
To cover these issues, the effects of kisspeptin-10 on GnRH and LH secretion were monitored at early stages of postnatal maturation, and potential changes in the sensitivity to kisspeptin were assessed along the pubertal transition in the rat.
Report a problemFND-1693081903
03LabEx vivo tissueActivity measurement
In hypothalamic explants from sexually immature rats, kisspeptin‑10 potently elicited GnRH release ex vivo from neonatal to juvenile stages.
In plain wordsIn lab tests on young rat brain tissue, kisspeptin‑10 strongly triggered GnRH release.
Peptide
Kisspeptin-10
Outcome
IncreaseGnRH release from hypothalamic explants in early postnatal rats
Study
ratn: not reported in source
Rat hypothalamic explants
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
Dose not stated
Source sentences
Summary
Despite sexual immaturity, kisspeptin-10 potently elicited GnRH release ex vivo
1 context sentence(design, population, supporting numbers)
Summary · context
To cover these issues, the effects of kisspeptin-10 on GnRH and LH secretion were monitored at early stages of postnatal maturation, and potential changes in the sensitivity to kisspeptin were assessed along the pubertal transition in the rat.
Report a problemFND-1693081901
04LabEx vivo tissueMechanism
In rat hypothalamic explants, kisspeptin‑10-stimulated GnRH secretion required activation of phospholipase-C.
In plain wordsIn lab tests on rat brain tissue, kisspeptin‑10 needed the enzyme phospholipase-C to trigger GnRH release.
Peptide
Kisspeptin-10
Outcome
Not applicableRole of phospholipase-C in kisspeptin-induced GnRH secretion
Study
ratn: not reported in source
Rat hypothalamic explants
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
Dose not stated
Source sentences
Summary
Concerning GnRH secretion, the stimulatory action of kisspeptin-10 required activation of phospholipase-C, mobilization of intracellular Ca2+ and recruitment of ERK1/2 and p38 kinases, but was preserved after blockade of type 2 cyclo-oxygenase and prostaglandin synthesis.
1 context sentence(design, population, supporting numbers)
Summary · context
To cover these issues, the effects of kisspeptin-10 on GnRH and LH secretion were monitored at early stages of postnatal maturation, and potential changes in the sensitivity to kisspeptin were assessed along the pubertal transition in the rat.
Report a problemFND-1693081904
05LabEx vivo tissueMechanism
In rat hypothalamic explants, kisspeptin‑10-stimulated GnRH secretion required mobilization of intracellular Ca2+.
In plain wordsIn lab tests on rat brain tissue, kisspeptin‑10 needed calcium release inside cells to trigger GnRH release.
Peptide
Kisspeptin-10
Outcome
Not applicableRole of intracellular Ca2+ in kisspeptin-induced GnRH secretion
Study
ratn: not reported in source
Rat hypothalamic explants
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
Dose not stated
Source sentences
Summary
Concerning GnRH secretion, the stimulatory action of kisspeptin-10 required activation of phospholipase-C, mobilization of intracellular Ca2+ and recruitment of ERK1/2 and p38 kinases, but was preserved after blockade of type 2 cyclo-oxygenase and prostaglandin synthesis.
1 context sentence(design, population, supporting numbers)
Summary · context
To cover these issues, the effects of kisspeptin-10 on GnRH and LH secretion were monitored at early stages of postnatal maturation, and potential changes in the sensitivity to kisspeptin were assessed along the pubertal transition in the rat.
Report a problemFND-1693081905
06LabEx vivo tissueMechanism
In rat hypothalamic explants, kisspeptin‑10-stimulated GnRH secretion required recruitment of ERK1/2 and p38 kinases.
In plain wordsIn lab tests on rat brain tissue, kisspeptin‑10 needed two signalling enzymes, ERK1/2 and p38, to trigger GnRH release.
Peptide
Kisspeptin-10
Outcome
Not applicableRole of ERK1/2 and p38 kinases in kisspeptin-induced GnRH secretion
Study
ratn: not reported in source
Rat hypothalamic explants
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
Dose not stated
Source sentences
Summary
Concerning GnRH secretion, the stimulatory action of kisspeptin-10 required activation of phospholipase-C, mobilization of intracellular Ca2+ and recruitment of ERK1/2 and p38 kinases, but was preserved after blockade of type 2 cyclo-oxygenase and prostaglandin synthesis.
1 context sentence(design, population, supporting numbers)
Summary · context
To cover these issues, the effects of kisspeptin-10 on GnRH and LH secretion were monitored at early stages of postnatal maturation, and potential changes in the sensitivity to kisspeptin were assessed along the pubertal transition in the rat.
Report a problemFND-1693081906
07LabEx vivo tissueMechanism
In rat hypothalamic explants, kisspeptin‑10-stimulated GnRH secretion was preserved after blockade of type 2 cyclo-oxygenase and prostaglandin synthesis.
In plain wordsIn lab tests on rat brain tissue, blocking the prostaglandin pathway did not stop kisspeptin‑10 from triggering GnRH release.
Peptide
Kisspeptin-10
Outcome
No significant changeEffect of cyclo-oxygenase 2 blockade on kisspeptin-induced GnRH secretion
Study
ratn: not reported in source
Rat hypothalamic explants
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
Dose not stated
Source sentences
Summary
Concerning GnRH secretion, the stimulatory action of kisspeptin-10 required activation of phospholipase-C, mobilization of intracellular Ca2+ and recruitment of ERK1/2 and p38 kinases, but was preserved after blockade of type 2 cyclo-oxygenase and prostaglandin synthesis.
1 context sentence(design, population, supporting numbers)
Summary · context
To cover these issues, the effects of kisspeptin-10 on GnRH and LH secretion were monitored at early stages of postnatal maturation, and potential changes in the sensitivity to kisspeptin were assessed along the pubertal transition in the rat.
Report a problemFND-1693081907

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
10 Oct 2026, 09:43 UTC
Study results updated
Version 1
9 Oct 2026, 03:04 UTC
First added · source update from Europe PMC

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