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Study · In vitro (cells) · rat · 2006

3 results

Actions of gonadotropin-releasing hormone analogues in pituitary gonadotrophs and their modulation by ovarian steroids.

Weiss JM, König SJ, Polack S, Emons G, Schulz KD, Diedrich K, Ortmann O

The Journal of steroid biochemistry and molecular biology7 Aug 2006Cited by 3 (Europe PMC)

PMID16891115 (opens in a new tab)DOI10.1016/j.jsbmb.2006.06.009 (opens in a new tab)PepBankPUB-16891115
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Mechanism

    In female rat pituitary cells, triptorelin reached its full suppressive effect on LH secretion after 3 h.

    In plain wordsIn cells from female rat pituitaries, triptorelin reached its full suppressive effect on LH secretion after 3 h.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    DecreaseLH secretion suppression
    Study

    ratn: not reported in source

    Female rat pituitary cells
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    0.1 nM · 3 hAs given in this study (rat).

    Source sentences

    Summary
    The suppressive effect of triptorelin on LH secretion was fully accomplished after 3 h of treatment, for cetrorelix only 10 min were sufficient.
    1 context sentence
    Summary · context
    Female rat pituitary cells were treated either with 0.1 nM triptorelin for 1, 2, 4 and 6 days or for 1, 3, 5 and 6 h or with 1, 10 or 100 nM cetrorelix for 1, 2, 3 and 5 h or for 10 min.
  2. 02LabIn vitro (cells)Mechanism

    In female rat pituitary cells, triptorelin significantly reduced total LH from 137 to 36 ng/ml after 1 h.

    In plain wordsIn cells from female rat pituitaries, triptorelin reduced total LH from 137 to 36 ng/ml after 1 h.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    DecreaseTotal LH pool
    Study

    ratn: not reported in source

    Female rat pituitary cells
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    0.1 nM · 1 hAs given in this study (rat).

    Measurements

    Total LH
    137 ng/ml
    before treatment
    Total LH
    36 ng/ml
    after 1 h

    Source sentences

    Summary
    Triptorelin suppressed total LH significantly (from 137 to 36 ng/ml) after 1 h in a time-dependent manner.
    1 context sentence
    Summary · context
    Female rat pituitary cells were treated either with 0.1 nM triptorelin for 1, 2, 4 and 6 days or for 1, 3, 5 and 6 h or with 1, 10 or 100 nM cetrorelix for 1, 2, 3 and 5 h or for 10 min.

Studies that did not test the peptide alone1

In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Triptorelin (Trelstar, Decapeptyl).

  1. 03LabNot a test of Triptorelin (Trelstar, Decapeptyl) aloneIn vitro (cells)Mechanism

    In female rat pituitary cells, steroid treatment enhanced the suppressive effects of triptorelin.

    In plain wordsIn cells from female rat pituitaries, steroids strengthened triptorelin suppression compared with cells without steroid treatment.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    IncreaseSteroid modulation of triptorelin suppression
    Study

    ratn: not reported in source

    Female rat pituitary cells
    Comparator
    Cells without steroid treatment
    Outcome group
    Sex hormones and fertility · Endocrine and hormones

    Source sentences

    Summary
    In steroid treated cells the suppressive effects of triptorelin were more distinct.
    2 context sentences
    Summary · context
    To test, whether the steroid milieu affects the actions of cetrorelix and triptorelin, cells were incubated for 52 h with 1 nM estradiol (E) alone or with combinations of 100 nM progesterone (P) for 4 or 52 h, respectively. Cells were then treated with 0.1 nM triptorelin for 9 h or 1 nM cetrorelix f…
    Summary · context
    Female rat pituitary cells were treated either with 0.1 nM triptorelin for 1, 2, 4 and 6 days or for 1, 3, 5 and 6 h or with 1, 10 or 100 nM cetrorelix for 1, 2, 3 and 5 h or for 10 min.

    In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Triptorelin (Trelstar, Decapeptyl).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Versions 3 to 4Current

    27 Oct 2026, 16:35 UTC

    The same notice was added 2 times, first on 27 Oct 2026, 16:35 UTC. The status did not change between them.

    Study data updated · source update from Europe PMC

  2. Version 2

    22 Oct 2026, 02:26 UTC

    Study results updated

  3. Version 1

    21 Oct 2026, 18:59 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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