Regulation of urea synthesis by glucose and glucagon in normal man.

Hamberg O, Vilstrup H

Clinical nutrition (Edinburgh, Scotland)1 Jun 1994Cited by 42 (Europe PMC)

PMID16843380DOI10.1016/0261-5614(94)90099-xPepBankPUB-16843380

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. 4 results from people.

01HumanNon-randomized trialMechanism
In healthy subjects, low stepwise glucagon infusion abolished the reduction of the glucagon response to alanine during glucose infusion.
In plain wordsIn healthy subjects, low stepwise glucagon infusion reversed the reduced glucagon response during glucose infusion.
Peptide
Glucagon
Outcome
IncreaseGlucagon response to alanine
Study
n = 7
Comparator
Glucose and alanine without added glucagon
Outcome group
Receptor activity and mechanism · Endocrine and hormones
Studied dose
Low stepwise infusionAs given in this study (human).
Source sentences
Summary
This reduction was abolished by the low stepwise glucagon infusion, aimed at re-establishing portal glucagon levels.
3 context sentences(design, population, supporting numbers)
Summary · context
Glucose halved the glucagon response to alanine.
Summary · context
The separate effects of glucose and glucagon on alanine stimulated hepatic amino-N to urea-N conversion, quantified by the Functional Hepatic Nitrogen Clearance (FHNC) (i.e. the linear slope of the relation between urea synthesis rate and blood alpha-amino-N concentration), were studied in 7 healthy subjects.
Summary · context
FHNC was measured four times in each: during constant infusion of alanine alone; alanine superimposed on constant glucose infusion; alanine superimposed on glucose and low stepwise glucagon infusions; and alanine super-imposed on glucose and high constant glucagon infusions.
Report a problemFND-1684338001
02HumanNon-randomized trialPharmacokinetics
In healthy subjects, high glucagon infusion produced 3-fold elevated glucagon levels.
In plain wordsIn healthy subjects, high glucagon infusion produced 3-fold elevated blood glucagon levels.
Peptide
Glucagon
Outcome
IncreaseGlucagon levels
Study
n = 7
Outcome group
Pharmacokinetics · Pharmacology
Studied dose
High constant infusionAs given in this study (human).
Measurements
Glucagon level elevation
3 fold
high glucagon infusion
Source sentences
Summary
The high glucagon infusion resulted in 3-fold elevated glucagon levels.
2 context sentences(design, population, supporting numbers)
Summary · context
The separate effects of glucose and glucagon on alanine stimulated hepatic amino-N to urea-N conversion, quantified by the Functional Hepatic Nitrogen Clearance (FHNC) (i.e. the linear slope of the relation between urea synthesis rate and blood alpha-amino-N concentration), were studied in 7 healthy subjects.
Summary · context
FHNC was measured four times in each: during constant infusion of alanine alone; alanine superimposed on constant glucose infusion; alanine superimposed on glucose and low stepwise glucagon infusions; and alanine super-imposed on glucose and high constant glucagon infusions.
Report a problemFND-1684338002
03HumanNon-randomized trialMechanism
In healthy subjects, low stepwise glucagon partly restored glucose-reduced hepatic nitrogen clearance to 24.6 +/- 1.5 l/h, below alanine alone (p < 0.01).
In plain wordsIn healthy subjects, low stepwise glucagon partly restored liver nitrogen clearance during glucose infusion, but clearance remained below alanine alone.
Peptide
Glucagon
Outcome
IncreaseFunctional hepatic nitrogen clearance
Study
n = 7
Comparator
Glucose and alanine without added glucagon
Outcome group
Liver fat and liver function · Liver
Studied dose
Low stepwise infusionAs given in this study (human).
Measurements
FHNC
24.6 l/h
low stepwise glucagon; +/- 1.5
Source sentences
Summary
The low stepwise glucagon infusion only partially normalized FHNC as reduced by glucose (to 24.6 +/- 1.5 l/h, (p < 0.01 vs alanine alone)).
3 context sentences(design, population, supporting numbers)
Summary · context
Glucose reduced FHNC by 43% to 18.4 +/- 0.9 l/h (p < 0.01).
Summary · context
The separate effects of glucose and glucagon on alanine stimulated hepatic amino-N to urea-N conversion, quantified by the Functional Hepatic Nitrogen Clearance (FHNC) (i.e. the linear slope of the relation between urea synthesis rate and blood alpha-amino-N concentration), were studied in 7 healthy subjects.
Summary · context
FHNC was measured four times in each: during constant infusion of alanine alone; alanine superimposed on constant glucose infusion; alanine superimposed on glucose and low stepwise glucagon infusions; and alanine super-imposed on glucose and high constant glucagon infusions.
Report a problemFND-1684338003
04HumanNon-randomized trialMechanism
In healthy subjects, high glucagon during glucose infusion increased hepatic nitrogen clearance by 35% to 44.1 +/- 1.5 l/h versus alanine alone (p < 0.01).
In plain wordsIn healthy subjects, high glucagon during glucose infusion increased liver nitrogen clearance compared with alanine alone.
Peptide
Glucagon
Outcome
IncreaseFunctional hepatic nitrogen clearance
Study
n = 7
Comparator
Alanine infusion alone
Outcome group
Liver fat and liver function · Liver
Studied dose
High constant infusionAs given in this study (human).
Measurements
FHNC increase
35%
high glucagon infusion with glucose, versus alanine alone
FHNC
44.1 l/h
high glucagon infusion; +/- 1.5
Source sentences
Summary
The high glucagon infusion increased FHNC by 35% despite hyperglycaemia (to 44.1 +/- 1.5 l/h, (p < 0.01 vs alanine alone)).
3 context sentences(design, population, supporting numbers)
Summary · context
Glucose reduced FHNC by 43% to 18.4 +/- 0.9 l/h (p < 0.01).
Summary · context
The separate effects of glucose and glucagon on alanine stimulated hepatic amino-N to urea-N conversion, quantified by the Functional Hepatic Nitrogen Clearance (FHNC) (i.e. the linear slope of the relation between urea synthesis rate and blood alpha-amino-N concentration), were studied in 7 healthy subjects.
Summary · context
FHNC was measured four times in each: during constant infusion of alanine alone; alanine superimposed on constant glucose infusion; alanine superimposed on glucose and low stepwise glucagon infusions; and alanine super-imposed on glucose and high constant glucagon infusions.
Report a problemFND-1684338004

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
28 Oct 2026, 02:03 UTC
Study results updated
Version 1
27 Oct 2026, 16:35 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

Journal Article

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