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Study · Non-randomized trial · n = 6 · 1994

4 results

Effect of lanreotide, a somatostatin analogue, on urea synthesis in normal man.

Wolthers T, Grøfte T, Orskov H, Hamberg O, Foegh M, Vilstrup H

Clinical nutrition (Edinburgh, Scotland)1 Apr 1994Cited by 1 (Europe PMC)

PMID16843368 (opens in a new tab)DOI10.1016/0261-5614(94)90068-x (opens in a new tab)PepBankPUB-16843368
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC-ND. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. 4 results from people.

  1. 01HumanNon-randomized trialEfficacy outcome

    In healthy men, low-dose lanreotide reduced urea nitrogen synthesis during amino acid infusion versus saline, with maxima of 85 +/- 12 versus 117 +/- 8 mmol/h.

    In plain wordsIn healthy men, low-dose lanreotide reduced urea nitrogen synthesis during amino acid infusion compared with saline.

    Peptide
    Lanreotide
    Outcome
    DecreaseUrea nitrogen synthesis rate
    Study

    n = 6

    Comparator
    Saline
    Outcome group
    Protein and amino acid metabolism · Metabolic and weight
    Studied dose
    5 mug/kgAs given in this study (human).

    Measurements

    Maximum urea nitrogen synthesis rate
    85 mmol/h
    lanreotide 5 mug/kg
    SE
    12 mmol/h
    lanreotide 5 mug/kg
    Maximum urea nitrogen synthesis rate
    117 mmol/h
    saline
    SE
    8 mmol/h
    saline

    Source sentences

    Summary
    Lanreotide decreased urea nitrogen synthesis rate (mmol/h) during amino acid infusion significantly compared to saline, independent of dose of lanreotide (max +/- SE of urea nitrogen synthesis rate measurements in each study: 117 +/- 8 mmol/h (saline), 85 +/- 10 mmol/h (high dose) and 85 +/- 12 mmol/h (low dose)).
    2 context sentences
    Summary · context
    We investigated the effect of lanreotide by measuring urea nitrogen synthesis rate (UNSR) and blood alpha-amino nitrogen levels before, during and after a 30 min iv infusion of 25 g of an electrolyte-free amino acid solution.
    Summary · context
    6 healthy male subjects were studied following, i) placebo (saline), ii) lanreotide 5 mug/kg, and iii) lanreotide 80 mug/kg.
  2. 02HumanNon-randomized trialEfficacy outcome

    In healthy men, high-dose lanreotide reduced urea nitrogen synthesis during amino acid infusion versus saline, with maxima of 85 +/- 10 versus 117 +/- 8 mmol/h.

    In plain wordsIn healthy men, high-dose lanreotide reduced urea nitrogen synthesis during amino acid infusion compared with saline.

    Peptide
    Lanreotide
    Outcome
    DecreaseUrea nitrogen synthesis rate
    Study

    n = 6

    Comparator
    Saline
    Outcome group
    Protein and amino acid metabolism · Metabolic and weight
    Studied dose
    80 mug/kgAs given in this study (human).

    Measurements

    Maximum urea nitrogen synthesis rate
    85 mmol/h
    lanreotide 80 mug/kg
    SE
    10 mmol/h
    lanreotide 80 mug/kg
    Maximum urea nitrogen synthesis rate
    117 mmol/h
    saline
    SE
    8 mmol/h
    saline

    Source sentences

    Summary
    Lanreotide decreased urea nitrogen synthesis rate (mmol/h) during amino acid infusion significantly compared to saline, independent of dose of lanreotide (max +/- SE of urea nitrogen synthesis rate measurements in each study: 117 +/- 8 mmol/h (saline), 85 +/- 10 mmol/h (high dose) and 85 +/- 12 mmol/h (low dose)).
    2 context sentences
    Summary · context
    We investigated the effect of lanreotide by measuring urea nitrogen synthesis rate (UNSR) and blood alpha-amino nitrogen levels before, during and after a 30 min iv infusion of 25 g of an electrolyte-free amino acid solution.
    Summary · context
    6 healthy male subjects were studied following, i) placebo (saline), ii) lanreotide 5 mug/kg, and iii) lanreotide 80 mug/kg.
  3. 03HumanNon-randomized trialEfficacy outcome

    In healthy men, low-dose lanreotide increased peak alpha-amino nitrogen to 4.8 +/- 0.2 versus 3.7 +/- 0.1 mmol/l with placebo (p < 0.01).

    In plain wordsIn healthy men, low-dose lanreotide increased peak alpha-amino nitrogen compared with placebo.

    Peptide
    Lanreotide
    Outcome
    IncreasePlasma alpha-amino nitrogen
    Study

    n = 6

    Comparator
    Saline
    Outcome group
    Protein and amino acid metabolism · Metabolic and weight
    Studied dose
    5 mug/kgAs given in this study (human).

    Measurements

    Peak alpha-amino nitrogen
    4.8 mmol/l
    lanreotide 5 mug/kg
    SE
    0.2 mmol/l
    lanreotide 5 mug/kg
    Peak alpha-amino nitrogen
    3.7 mmol/l
    placebo
    SE
    0.1 mmol/l
    placebo
    P value
    < 0.01
    low dose versus placebo

    Source sentences

    Summary
    This occurred in spite of significantly higher plasma alpha-amino nitrogen following lanreotide (peak +/- SE of alpha-amino nitrogen level in each study: 3.7 +/- 0.1 mmol/l placebo versus 4.8 +/- 0.2 mmol/l low dose and 4.7 +/- 0.4 mmol/l high dose (p < 0.01).
    2 context sentences
    Summary · context
    We investigated the effect of lanreotide by measuring urea nitrogen synthesis rate (UNSR) and blood alpha-amino nitrogen levels before, during and after a 30 min iv infusion of 25 g of an electrolyte-free amino acid solution.
    Summary · context
    6 healthy male subjects were studied following, i) placebo (saline), ii) lanreotide 5 mug/kg, and iii) lanreotide 80 mug/kg.
  4. 04HumanNon-randomized trialEfficacy outcome

    In healthy men, high-dose lanreotide increased peak alpha-amino nitrogen to 4.7 +/- 0.4 versus 3.7 +/- 0.1 mmol/l with placebo (p < 0.01).

    In plain wordsIn healthy men, high-dose lanreotide increased peak alpha-amino nitrogen compared with placebo.

    Peptide
    Lanreotide
    Outcome
    IncreasePlasma alpha-amino nitrogen
    Study

    n = 6

    Comparator
    Saline
    Outcome group
    Protein and amino acid metabolism · Metabolic and weight
    Studied dose
    80 mug/kgAs given in this study (human).

    Measurements

    Peak alpha-amino nitrogen
    4.7 mmol/l
    lanreotide 80 mug/kg
    SE
    0.4 mmol/l
    lanreotide 80 mug/kg
    Peak alpha-amino nitrogen
    3.7 mmol/l
    placebo
    SE
    0.1 mmol/l
    placebo
    P value
    < 0.01
    high dose versus placebo

    Source sentences

    Summary
    This occurred in spite of significantly higher plasma alpha-amino nitrogen following lanreotide (peak +/- SE of alpha-amino nitrogen level in each study: 3.7 +/- 0.1 mmol/l placebo versus 4.8 +/- 0.2 mmol/l low dose and 4.7 +/- 0.4 mmol/l high dose (p < 0.01).
    2 context sentences
    Summary · context
    We investigated the effect of lanreotide by measuring urea nitrogen synthesis rate (UNSR) and blood alpha-amino nitrogen levels before, during and after a 30 min iv infusion of 25 g of an electrolyte-free amino acid solution.
    Summary · context
    6 healthy male subjects were studied following, i) placebo (saline), ii) lanreotide 5 mug/kg, and iii) lanreotide 80 mug/kg.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    28 Oct 2026, 02:03 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:36 UTC

    First added · source update from Europe PMC

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