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Study · Animal study (in vivo) · rat · 2006

5 results

Accelerated healing of excisional skin wounds by PL 14736 in alloxan-hyperglycemic rats.

Seveljević-Jaran D, Cuzić S, Dominis-Kramarić M, Glojnarić I, Ivetić V, Radosević S, Parnham MJ

Skin pharmacology and physiology16 Jun 2006Cited by 26 (Europe PMC)

PMID16785777 (opens in a new tab)DOI10.1159/000093982 (opens in a new tab)PepBankPUB-16785777
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In hyperglycemic rats with delayed healing, PL 14736 produced a dose-dependent acceleration of wound healing, equivalent at the highest doses to becaplermin.

    In plain wordsIn rats with high blood sugar, PL 14736 gel sped up wound healing, as much as becaplermin at the highest doses.

    Peptide
    BPC-157
    Outcome
    IncreaseWound healing by macroscopic score
    Study

    ratn: not reported in source

    Full-thickness excisional wounds in alloxan-hyperglycemic rats
    Comparator
    Becaplermin gel
    Outcome group
    Wound healing · Skin and wound
    Studied dose
    10-1,000 microg/wound · topical gelAs given in this study (rat).

    Source sentences

    Summary
    While healing was too rapid in healthy rats to observe enhancement by either treatment, in the hyperglycemic rats which exhibited delayed healing, PL 14736 (10-1,000 microg/wound) produced a dose-dependent acceleration of wound healing (determined by macroscopic scoring) equivalent at the highest do…
    1 context sentence
    Summary · context
    To investigate its possible benefit in poorly healing skin wounds, the effects of the topical application of PL 14736 in a gel formulation have been studied on full-thickness excisional wounds in rats, either healthy or made hyperglycemic by alloxan (175 mg/kg s.c.) 5 days previously.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In healthy rats, healing was too rapid to observe enhancement by PL 14736 or becaplermin.

    In plain wordsIn healthy rats, wounds healed too fast to see any added benefit from PL 14736.

    Peptide
    BPC-157
    Outcome
    No significant changeWound healing in healthy rats
    Study

    ratn: not reported in source

    Full-thickness excisional wounds in healthy rats
    Outcome group
    Wound healing · Skin and wound
    Studied dose
    Dose not stated · topical gelAs given in this study (rat).

    Source sentences

    Summary
    While healing was too rapid in healthy rats to observe enhancement by either treatment, in the hyperglycemic rats which exhibited delayed healing, PL 14736 (10-1,000 microg/wound) produced a dose-dependent acceleration of wound healing (determined by macroscopic scoring) equivalent at the highest do…
    1 context sentence
    Summary · context
    To investigate its possible benefit in poorly healing skin wounds, the effects of the topical application of PL 14736 in a gel formulation have been studied on full-thickness excisional wounds in rats, either healthy or made hyperglycemic by alloxan (175 mg/kg s.c.) 5 days previously.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In hyperglycemic rats, the healing benefit of PL 14736, like becaplermin, was associated with increased deposition of organized granulation tissue by day 7.

    In plain wordsIn rats with high blood sugar, PL 14736 gel, like becaplermin, increased well-organized new repair tissue by day 7.

    Peptide
    BPC-157
    Outcome
    IncreaseOrganized granulation tissue deposition at day 7
    Study

    ratn: not reported in source

    Full-thickness excisional wounds in alloxan-hyperglycemic rats
    Comparator
    Becaplermin gel
    Outcome group
    Wound healing · Skin and wound
    Studied dose
    10-1,000 microg/wound · topical gelAs given in this study (rat).

    Source sentences

    Summary
    The beneficial effect on healing was associated with increased deposition of organized granulation tissue by day 7 for both PL 14736 and becaplermin, as determined histologically.
    1 context sentence
    Summary · context
    To investigate its possible benefit in poorly healing skin wounds, the effects of the topical application of PL 14736 in a gel formulation have been studied on full-thickness excisional wounds in rats, either healthy or made hyperglycemic by alloxan (175 mg/kg s.c.) 5 days previously.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In hyperglycemic rats, PL 14736 tended to have a greater effect than becaplermin on formation of granulation tissue containing mature collagen.

    In plain wordsIn rats with high blood sugar, PL 14736 tended to form more mature collagen tissue than becaplermin.

    Peptide
    BPC-157
    Outcome
    IncreaseGranulation tissue with mature collagen
    Study

    ratn: not reported in source

    Full-thickness excisional wounds in alloxan-hyperglycemic rats
    Comparator
    Becaplermin gel
    Outcome group
    Wound healing · Skin and wound
    Studied dose
    Dose not stated · topical gelAs given in this study (rat).

    Source sentences

    Summary
    PL 14736 tended to have a greater effect than becaplermin on the formation of granulation tissue containing mature collagen.
    1 context sentence
    Summary · context
    To investigate its possible benefit in poorly healing skin wounds, the effects of the topical application of PL 14736 in a gel formulation have been studied on full-thickness excisional wounds in rats, either healthy or made hyperglycemic by alloxan (175 mg/kg s.c.) 5 days previously.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In hyperglycemic rats, wound contraction measured by planimetry was not significantly affected by PL 14736.

    In plain wordsIn rats with high blood sugar, PL 14736 gel did not significantly change how much wounds shrank.

    Peptide
    BPC-157
    Outcome
    No significant changeWound contraction
    Study

    ratn: not reported in source

    Full-thickness excisional wounds in alloxan-hyperglycemic rats
    Comparator
    Becaplermin gel
    Outcome group
    Wound healing · Skin and wound
    Studied dose
    Dose not stated · topical gelAs given in this study (rat).

    Source sentences

    Summary
    Wound contraction, as measured by planimetry, was not significantly affected.
    1 context sentence
    Summary · context
    To investigate its possible benefit in poorly healing skin wounds, the effects of the topical application of PL 14736 in a gel formulation have been studied on full-thickness excisional wounds in rats, either healthy or made hyperglycemic by alloxan (175 mg/kg s.c.) 5 days previously.

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    10 Oct 2026, 08:19 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 02:56 UTC

    First added · source update from Europe PMC

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