Skip to content

Study · Non-randomized trial · n = 57 · 2006

4 results

[Pituitary response to GnRH analogue testing in girls with a polycystic ovary syndrome].

Wikiera B, Wasikowa R

Endokrynologia, diabetologia i choroby przemiany materii wieku rozwojowego : organ Polskiego Towarzystwa Endokrynologow Dzieciecych1 Jan 2006

PMID16704856 (opens in a new tab)PepBankPUB-16704856
Publisher pageAsk about this study
Jump to 4 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. 4 results from people.

  1. 01HumanNon-randomized trialActivity measurement

    In girls with hirsutism, mean LH concentration increased in all groups after GnRH analogue administration and peaked after 2 hours.

    In plain wordsIn girls with hirsutism, LH levels rose in all groups after a GnRH analogue injection and peaked after 2 hours.

    Peptide
    Gonadorelin (GnRH, LHRH)
    Outcome
    IncreaseLH response to GnRH analogue
    Study

    n = 57

    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    100 microg · subcutaneousAs given in this study (human).

    Source sentences

    Summary
    After GnRH analogue administration mean LH concentration increased in all groups and peaked after 2 hours.
    2 context sentences
    Summary · context
    57 girls with hirsutism, mean age 15.9 years, were involved in the study.
    Summary · context
    Basal blood samples were drawn at 8 a.m. GnRH analogue (Relefact LH-RH) 100 microg was then given subcutaneously and blood samples were drawn every 4 hours for 24 hours.
  2. 02HumanNon-randomized trialActivity measurement

    After GnRH analogue, FSH secretion was similar in all tested groups of girls with hirsutism.

    In plain wordsAfter a GnRH analogue injection, FSH release was similar in all three groups of girls.

    Peptide
    Gonadorelin (GnRH, LHRH)
    Outcome
    No significant changeFSH response to GnRH analogue, between groups
    Study

    n = 57

    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    100 microg · subcutaneousAs given in this study (human).

    Source sentences

    Summary
    The FSH secretion in all tested groups was similar.
    2 context sentences
    Summary · context
    57 girls with hirsutism, mean age 15.9 years, were involved in the study.
    Summary · context
    Basal blood samples were drawn at 8 a.m. GnRH analogue (Relefact LH-RH) 100 microg was then given subcutaneously and blood samples were drawn every 4 hours for 24 hours.
  3. 03HumanNon-randomized trialActivity measurement

    After GnRH analogue injection, FSH peaked after 2 hours and decreased slightly during the next 2 hours.

    In plain wordsAfter a GnRH analogue injection, FSH peaked after 2 hours and then fell slightly.

    Peptide
    Gonadorelin (GnRH, LHRH)
    Outcome
    IncreaseFSH time course after GnRH analogue
    Study

    n = 57

    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    100 microg · subcutaneousAs given in this study (human).

    Source sentences

    Summary
    It peaked, like LH, after 2 hours after GnRH analogue injection and decreased slightly during next 2 hours.
    2 context sentences
    Summary · context
    57 girls with hirsutism, mean age 15.9 years, were involved in the study.
    Summary · context
    Basal blood samples were drawn at 8 a.m. GnRH analogue (Relefact LH-RH) 100 microg was then given subcutaneously and blood samples were drawn every 4 hours for 24 hours.
  4. 04HumanNon-randomized trialActivity measurement

    After GnRH analogue, stimulated LH was highest in girls with PCOS (group I) and differed significantly from group III throughout the test.

    In plain wordsAfter a GnRH analogue injection, LH rose most in girls with PCOS, and this differed from girls in group III.

    Peptide
    Gonadorelin (GnRH, LHRH)
    Outcome
    Not applicableStimulated LH level, PCOS group versus group without menstrual or androgen abnormalities
    Study

    n: not reported in source

    Comparator
    Group III (no menstruation disorders, no elevated androgens)
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    100 microg · subcutaneousAs given in this study (human).

    Source sentences

    Summary
    Stimulated LH level was the highest in group I and differed statistically significantly from group III during the whole period of the test. The most significant difference occurred at 12 a.m. (p=0.003) and 10 a.m. (p=0.004).
    2 context sentences
    Summary · context
    57 girls with hirsutism, mean age 15.9 years, were involved in the study.
    Summary · context
    Basal blood samples were drawn at 8 a.m. GnRH analogue (Relefact LH-RH) 100 microg was then given subcutaneously and blood samples were drawn every 4 hours for 24 hours.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.