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Study · In vitro (cells) · 2006

5 results

Thymosin beta4 and AcSDKP inhibit the proliferation of HL-60 cells and induce their differentiation and apoptosis.

Huang WQ, Wang BH, Wang QR

Cell biology international6 Mar 2006Cited by 26 (Europe PMC)

PMID16677835 (opens in a new tab)DOI10.1016/j.cellbi.2006.01.009 (opens in a new tab)PepBankPUB-16677835
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Activity measurement

    In HL-60 cells, Tbeta4 had a dose-dependent inhibitory effect on proliferation.

    In plain wordsIn cells, Tbeta4 slowed the growth of HL-60 leukemia cells in a dose-dependent way.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    DecreaseHL-60 cell proliferation
    Study

    humann: not reported in source

    HL-60 leukemic cells
    Outcome group
    Tumor growth · Cancer
    Studied dose
    10(-11)-10(-7) mol/LAs given in this study (human).

    Source sentences

    Summary
    Tbeta4 (10(-11)-10(-7)mol/L) and AcSDKP (10(-11)-10(-7)mol/L) had the dose-dependent inhibitory effect on the proliferation of HL-60 cells
    1 context sentence
    Summary · context
    This study was performed to evaluate the effect of Tbeta4 and AcSDKP on the growth of HL-60 cells.
  2. 02LabIn vitro (cells)Activity measurement

    In HL-60 cells, Tbeta4 induced differentiation based on cell morphology and NBT reduction.

    In plain wordsIn cells, Tbeta4 pushed HL-60 leukemia cells to mature.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseHL-60 cell differentiation
    Study

    humann: not reported in source

    HL-60 leukemic cells
    Outcome group
    Tumor growth · Cancer
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Based on cell morphology and NBT reduction, Tbeta4 and AcSDKP induced differentiation of HL-60 cells.
    1 context sentence
    Summary · context
    This study was performed to evaluate the effect of Tbeta4 and AcSDKP on the growth of HL-60 cells.
  3. 03LabIn vitro (cells)Activity measurement

    In HL-60 cells, Tbeta4 induced apoptosis on morphologic and DNA fragment analysis.

    In plain wordsIn cells, Tbeta4 caused HL-60 leukemia cells to die by apoptosis.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseHL-60 cell apoptosis
    Study

    humann: not reported in source

    HL-60 leukemic cells
    Outcome group
    Tumor growth · Cancer
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Morphologic and DNA fragment analysis proved that Tbeta4 and AcSDKP induced apoptosis of HL-60 cells.
    1 context sentence
    Summary · context
    This study was performed to evaluate the effect of Tbeta4 and AcSDKP on the growth of HL-60 cells.
  4. 04LabIn vitro (cells)Mechanism

    In HL-60 cells, Tbeta4 increased intracellular free Ca2+ by stimulating release from intracellular Ca2+ pools.

    In plain wordsIn cells, Tbeta4 raised calcium levels inside HL-60 leukemia cells.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseIntracellular free calcium in HL-60 cells
    Study

    humann: not reported in source

    HL-60 leukemic cells
    Outcome group
    Tumor growth · Cancer
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The results showed that Tbeta4 and AcSDKP could increased [Ca(2+)](i) by stimulating the release of Ca(2+) from intracellular Ca(2+) pool.
    1 context sentence
    Summary · context
    This study was performed to evaluate the effect of Tbeta4 and AcSDKP on the growth of HL-60 cells.
  5. 05LabIn vitro (cells)Mechanism

    In leukemic cells, Tbeta4 changed apoptosis-related gene expression, with inhibition of proliferation and induction of differentiation and apoptosis.

    In plain wordsIn cells, Tbeta4 changed genes linked to cell death in leukemia cells. The abstract does not give the direction.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    Direction not reportedApoptosis-related gene expression in leukemic cells
    Study

    humann: not reported in source

    HL-60 leukemic cells
    Outcome group
    Tumor growth · Cancer
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Tbeta4 could also change apoptotic-related gene expression in leukemic cells, and resulted in the inhibition of proliferation and induction of differentiation and apoptosis of leukemic cells.
    1 context sentence
    Summary · context
    This study was performed to evaluate the effect of Tbeta4 and AcSDKP on the growth of HL-60 cells.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 01:52 UTC

    Study results updated

  2. Version 1

    12 Oct 2026, 18:17 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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