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Study · Measured the body's own peptide · 2006

3 results

Humanin expression in skeletal muscles of patients with chronic progressive external ophthalmoplegia.

Kin T, Sugie K, Hirano M, Goto YI, Nishino I, Ueno S

Journal of human genetics26 Apr 2006Cited by 32 (Europe PMC)

PMID16639504 (opens in a new tab)DOI10.1007/s10038-006-0397-2 (opens in a new tab)PepBankPUB-16639504
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

No result from this study comes from a test of the peptide.

Natural levels measured3

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01HumanEndogenous levelCase report or seriesOther

    In skeletal muscle of four patients with chronic progressive external ophthalmoplegia (CPEO) with different mitochondrial DNA mutations, humanin expression was found in all of them.

    In plain wordsIn four people with a mitochondrial muscle disease, the body's own humanin was found in muscle in all four.

    Peptide
    Humanin
    Outcome
    Not applicableHumanin expression in CPEO muscle
    Study

    n = 4

    Outcome group
    Mitochondrial function · Musculoskeletal

    Source sentences

    Summary
    We found HN expression in all four patients examined, each of whom had different mitochondrial DNA mutations including two different single DNA deletions, multiple deletions, and no major mutations detected.
    1 context sentence
    Summary · context
    We showed that humanin (HN), an endogenous peptide against Alzheimer disease-related insults, was expressed in muscles of patients with chronic progressive external ophthalmoplegia (CPEO), a major mitochondrial disease.

    This result measures the body's own Humanin. Nobody was given the peptide. It is not evidence about taking it.

  2. 02HumanEndogenous levelCase report or seriesOther

    In skeletal muscle of patients with CPEO, humanin expression was not linked to focal cytochrome c deficiency.

    In plain wordsIn people with a mitochondrial muscle disease, the body's own humanin was not linked to a specific enzyme deficiency in muscle fibers.

    Peptide
    Humanin
    Outcome
    No significant changeHumanin expression versus focal cytochrome c deficiency
    Study

    n: not reported in source

    Outcome group
    Mitochondrial function · Musculoskeletal

    Source sentences

    Summary
    We also found that HN expression was not linked to focal cytochrome c deficiency, strongly associated with the subtype of CPEO with single deletions.

    This result measures the body's own Humanin. Nobody was given the peptide. It is not evidence about taking it.

  3. 03HumanEndogenous levelCase report or seriesOther

    Humanin was also expressed in non-degenerative muscle fibers of patients with CPEO or Leigh syndrome who carried the 8993T>G mutation in the mitochondrial ATPase 6 gene.

    In plain wordsIn people with mitochondrial muscle disease, the body's own humanin was also found in muscle fibers that were not degenerating.

    Peptide
    Humanin
    Outcome
    Not applicableHumanin expression in non-degenerative muscle fibers
    Study

    n: not reported in source

    Outcome group
    Mitochondrial function · Musculoskeletal

    Source sentences

    Summary
    Notably, HN was also expressed in non-degenerative muscle fibers of patients with CPEO or Leigh syndrome, who had the 8993T>G mutation in the mitochondrial ATPase 6 gene known to be associated with impaired ATP synthesis.

    This result measures the body's own Humanin. Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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