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Study · In vitro (cells) · 2006

3 results

Thymosin beta4 inhibits benzalkonium chloride-mediated apoptosis in corneal and conjunctival epithelial cells in vitro.

Sosne G, Albeiruti AR, Hollis B, Siddiqi A, Ellenberg D, Kurpakus-Wheater M

Experimental eye research21 Apr 2006Cited by 38 (Europe PMC)

PMID16630613 (opens in a new tab)DOI10.1016/j.exer.2006.02.001 (opens in a new tab)PepBankPUB-16630613
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Activity measurement

    In human conjunctival and corneal epithelial cells, Tbeta4 did not protect against BAK-induced inhibition of proliferation.

    In plain wordsIn cells, Tbeta4 did not protect eye surface cells from the slowing of growth caused by BAK.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    No significant changeBAK-induced inhibition of DNA synthesis
    Study

    humann: not reported in source

    human conjunctival (HC0597) and corneal (HCET, HCEC) epithelial cells exposed to BAK
    Outcome group
    Wound healing · Eye
    Studied dose
    1 microg/ml · 3 or 24 hAs given in this study (human).

    Source sentences

    Summary
    Tbeta(4) did not protect the epithelial cells from BAK-induced inhibition of proliferation.
    1 context sentence
    Summary · context
    Human conjunctival epithelial cells (HC0597) or human corneal epithelial cells (HCET) were treated with 0%, 0.001%, 0.01%, or 0.1% BAK for 15 min. After 3 or 24h of recovery in culture medium containing 1 microg/ml Tbeta(4), a dosage that has been demonstrated effective in several published studies,…
  2. 02LabIn vitro (cells)Activity measurement

    In human conjunctival epithelial cells (HC0597), Tbeta4 significantly inhibited apoptosis initiated by BAK.

    In plain wordsIn cells, Tbeta4 reduced BAK-triggered cell death in human conjunctival cells.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    DecreaseBAK-induced apoptosis in HC0597 conjunctival cells
    Study

    humann: not reported in source

    human conjunctival (HC0597) and corneal (HCET, HCEC) epithelial cells exposed to BAK
    Comparator
    BAK alone
    Outcome group
    Wound healing · Eye
    Studied dose
    Dose not stated · up to 5 daysAs given in this study (human).

    Source sentences

    Summary
    Treatment of HC0597 cells with Tbeta(4) significantly inhibited the apoptosis shown to be initiated by BAK.
  3. 03LabIn vitro (cells)Activity measurement

    In non-transformed human corneal epithelial cells (HCEC), Tbeta4 significantly inhibited BAK-initiated apoptosis at later times in culture.

    In plain wordsIn cells, Tbeta4 reduced BAK-triggered cell death in human corneal cells at later times.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    DecreaseBAK-induced apoptosis in non-transformed corneal cells
    Study

    humann: not reported in source

    human conjunctival (HC0597) and corneal (HCET, HCEC) epithelial cells exposed to BAK
    Comparator
    BAK alone
    Outcome group
    Wound healing · Eye
    Studied dose
    Dose not stated · up to 5 daysAs given in this study (human).

    Source sentences

    Summary
    Treatment of non-transformed human corneal epithelial cells (HCEC) with Tbeta(4) also significantly inhibited the apoptosis shown to be initiated by BAK at later times in culture.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 01:52 UTC

    Study results updated

  2. Version 1

    12 Oct 2026, 18:17 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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