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Study · Animal study (in vivo) · rat · 2006

4 results

Administration of kisspeptin-54 into discrete regions of the hypothalamus potently increases plasma luteinising hormone and testosterone in male adult rats.

Patterson M, Murphy KG, Thompson EL, Patel S, Ghatei MA, Bloom SR

Journal of neuroendocrinology1 May 2006Cited by 61 (Europe PMC)

PMID16629833 (opens in a new tab)DOI10.1111/j.1365-2826.2006.01420.x (opens in a new tab)PepBankPUB-16629833
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In adult male rats, kisspeptin‑54 injected into the medial preoptic area significantly increased plasma LH at 60 minutes at doses of 1, 10 and 100 pmol.

    In plain wordsIn male rats, kisspeptin‑54 injected into a brain region raised LH in the blood.

    Peptide
    Kisspeptin-54 (metastin)
    Outcome
    IncreasePlasma LH after kisspeptin-54 into MPOA
    Study

    ratn: not reported in source

    Adult male Wistar rats
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    1, 10 or 100 pmol · intrahypothalamic injectionAs given in this study (rat).

    Source sentences

    Summary
    At 60 min following injection of 1, 10 or 100 pmol kisspeptin-54, plasma luteinising hormone (LH) and total testosterone levels were significantly increased.
    1 context sentence
    Summary · context
    Kisspeptin-54 was injected into the MPOA at doses of 0.01, 0.1, 1, 10 and 100 pmol.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In adult male rats, kisspeptin‑54 injected into the medial preoptic area significantly increased total testosterone at 60 minutes at doses of 1, 10 and 100 pmol.

    In plain wordsIn male rats, kisspeptin‑54 injected into a brain region raised testosterone in the blood.

    Peptide
    Kisspeptin-54 (metastin)
    Outcome
    IncreasePlasma total testosterone after kisspeptin-54 into MPOA
    Study

    ratn: not reported in source

    Adult male Wistar rats
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    1, 10 or 100 pmol · intrahypothalamic injectionAs given in this study (rat).

    Source sentences

    Summary
    At 60 min following injection of 1, 10 or 100 pmol kisspeptin-54, plasma luteinising hormone (LH) and total testosterone levels were significantly increased.
    1 context sentence
    Summary · context
    Kisspeptin-54 was injected into the MPOA at doses of 0.01, 0.1, 1, 10 and 100 pmol.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In adult male rats, 1 pmol kisspeptin‑54 injected into the RPOA, MPOA, PVN or arcuate nucleus significantly increased circulating LH at 60 minutes.

    In plain wordsIn male rats, a small kisspeptin‑54 dose in four brain regions raised LH in the blood.

    Peptide
    Kisspeptin-54 (metastin)
    Outcome
    IncreasePlasma LH after 1 pmol kisspeptin-54 into hypothalamic regions
    Study

    ratn: not reported in source

    Adult male Wistar rats
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    1 pmol · intrahypothalamic injectionAs given in this study (rat).

    Source sentences

    Summary
    The circulating levels of LH and total testosterone were significantly increased 60 min postinjection of kisspeptin-54 into the RPOA, MPOA, PVN and arcuate nucleus.
    1 context sentence
    Summary · context
    A dose of 1 pmol kisspeptin-54 was administered into all areas.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In adult male rats, 1 pmol kisspeptin‑54 injected into the RPOA, MPOA, PVN or arcuate nucleus significantly increased circulating total testosterone at 60 minutes.

    In plain wordsIn male rats, a small kisspeptin‑54 dose in four brain regions raised testosterone in the blood.

    Peptide
    Kisspeptin-54 (metastin)
    Outcome
    IncreasePlasma total testosterone after 1 pmol kisspeptin-54 into hypothalamic regions
    Study

    ratn: not reported in source

    Adult male Wistar rats
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    1 pmol · intrahypothalamic injectionAs given in this study (rat).

    Source sentences

    Summary
    The circulating levels of LH and total testosterone were significantly increased 60 min postinjection of kisspeptin-54 into the RPOA, MPOA, PVN and arcuate nucleus.
    1 context sentence
    Summary · context
    A dose of 1 pmol kisspeptin-54 was administered into all areas.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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