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Study · Animal study (in vivo) · rat · 2006

10 results

Effective therapy of transected quadriceps muscle in rat: Gastric pentadecapeptide BPC 157.

Staresinic M, Petrovic I, Novinscak T, Jukic I, Pevec D, Suknaic S, Kokic N, Batelja L, Brcic L, Boban-Blagaic A, Zoric Z, Ivanovic D and 8 more

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Ajduk M, Sebecic B, Patrlj L, Sosa T, Buljat G, Anic T, Seiwerth S, Sikiric P

Journal of orthopaedic research : official publication of the Orthopaedic Research Society1 May 2006Cited by 53 (Europe PMC)

PMID16609979 (opens in a new tab)DOI10.1002/jor.20089 (opens in a new tab)PepBankPUB-16609979
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study10

10 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats with transected quadriceps muscle, BPC‑157 consistently improved muscle healing throughout the whole 72-day period.

    In plain wordsIn rats with a cut thigh muscle, BPC‑157 improved muscle healing throughout the 72-day period.

    Peptide
    BPC-157
    Outcome
    IncreaseMuscle healing over 72 days
    Study

    ratn: not reported in source

    Complete quadriceps muscle transection
    Outcome group
    Muscle injury and repair · Musculoskeletal
    Studied dose
    10 microg/kg, 10 ng/kg, 10 pg/kg · intraperitoneal · once daily; 72-day periodAs given in this study (rat).

    Source sentences

    Summary
    It consistently improves muscle healing throughout the whole 72-day period.
    2 context sentences
    Summary · context
    Regularly, quadriceps muscle completely transected transversely 1.0 cm proximal to patella presents a definitive defect that cannot be compensated in rat.
    Summary · context
    BPC 157 (10 microg, 10 ng, 10 pg/kg) is given intraperitoneally, once daily; the first application 30 min posttransection, the final 24 h before sacrifice.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats with transected quadriceps muscle, BPC‑157 increased load of failure.

    In plain wordsIn rats with a cut thigh muscle, BPC‑157 increased the load the healed muscle could bear before failing.

    Peptide
    BPC-157
    Outcome
    IncreaseBiomechanics (load of failure)
    Study

    ratn: not reported in source

    Complete quadriceps muscle transection
    Outcome group
    Muscle injury and repair · Musculoskeletal
    Studied dose
    10 microg/kg, 10 ng/kg, 10 pg/kg · intraperitoneal · once daily; 72-day periodAs given in this study (rat).

    Source sentences

    Summary
    biomechanic (load of failure increased
    2 context sentences
    Summary · context
    Regularly, quadriceps muscle completely transected transversely 1.0 cm proximal to patella presents a definitive defect that cannot be compensated in rat.
    Summary · context
    BPC 157 (10 microg, 10 ng, 10 pg/kg) is given intraperitoneally, once daily; the first application 30 min posttransection, the final 24 h before sacrifice.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In rats with transected quadriceps muscle, walking recovery returned toward normal healthy values with BPC‑157.

    In plain wordsIn rats with a cut thigh muscle, BPC‑157 helped walking return toward normal.

    Peptide
    BPC-157
    Outcome
    IncreaseWalking recovery
    Study

    ratn: not reported in source

    Complete quadriceps muscle transection
    Outcome group
    Exercise and physical function · Musculoskeletal
    Studied dose
    10 microg/kg, 10 ng/kg, 10 pg/kg · intraperitoneal · once daily; 72-day periodAs given in this study (rat).

    Source sentences

    Summary
    walking recovery and extensor postural thrust/motor function index returned toward normal healthy values
    2 context sentences
    Summary · context
    Regularly, quadriceps muscle completely transected transversely 1.0 cm proximal to patella presents a definitive defect that cannot be compensated in rat.
    Summary · context
    BPC 157 (10 microg, 10 ng, 10 pg/kg) is given intraperitoneally, once daily; the first application 30 min posttransection, the final 24 h before sacrifice.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In rats with transected quadriceps muscle, extensor postural thrust and the motor function index returned toward normal healthy values with BPC‑157.

    In plain wordsIn rats with a cut thigh muscle, BPC‑157 helped leg push strength and motor function return toward normal.

    Peptide
    BPC-157
    Outcome
    IncreaseExtensor postural thrust / motor function index
    Study

    ratn: not reported in source

    Complete quadriceps muscle transection
    Outcome group
    Exercise and physical function · Musculoskeletal
    Studied dose
    10 microg/kg, 10 ng/kg, 10 pg/kg · intraperitoneal · once daily; 72-day periodAs given in this study (rat).

    Source sentences

    Summary
    walking recovery and extensor postural thrust/motor function index returned toward normal healthy values
    2 context sentences
    Summary · context
    Regularly, quadriceps muscle completely transected transversely 1.0 cm proximal to patella presents a definitive defect that cannot be compensated in rat.
    Summary · context
    BPC 157 (10 microg, 10 ng, 10 pg/kg) is given intraperitoneally, once daily; the first application 30 min posttransection, the final 24 h before sacrifice.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In rats with transected quadriceps muscle, BPC‑157 treatment gave mostly muscle fibers connecting muscle segments and an absent gap.

    In plain wordsIn rats with a cut thigh muscle, BPC‑157 treatment gave muscle fibers that connected the cut ends with no gap.

    Peptide
    BPC-157
    Outcome
    IncreaseMuscle fiber continuity and gap
    Study

    ratn: not reported in source

    Complete quadriceps muscle transection
    Outcome group
    Muscle injury and repair · Musculoskeletal
    Studied dose
    10 microg/kg, 10 ng/kg, 10 pg/kg · intraperitoneal · once daily; 72-day periodAs given in this study (rat).

    Source sentences

    Summary
    mostly muscle fibers connect muscle segments; absent gap
    2 context sentences
    Summary · context
    Regularly, quadriceps muscle completely transected transversely 1.0 cm proximal to patella presents a definitive defect that cannot be compensated in rat.
    Summary · context
    BPC 157 (10 microg, 10 ng, 10 pg/kg) is given intraperitoneally, once daily; the first application 30 min posttransection, the final 24 h before sacrifice.
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In rats with transected quadriceps muscle, BPC‑157 treatment gave significant desmin positivity for ongoing regeneration of muscle.

    In plain wordsIn rats with a cut thigh muscle, BPC‑157 treatment gave signs of ongoing muscle regrowth.

    Peptide
    BPC-157
    Outcome
    IncreaseDesmin positivity (muscle regeneration)
    Study

    ratn: not reported in source

    Complete quadriceps muscle transection
    Outcome group
    Muscle injury and repair · Musculoskeletal
    Studied dose
    10 microg/kg, 10 ng/kg, 10 pg/kg · intraperitoneal · once daily; 72-day periodAs given in this study (rat).

    Source sentences

    Summary
    significant desmin positivity for ongoing regeneration of muscle
    2 context sentences
    Summary · context
    Regularly, quadriceps muscle completely transected transversely 1.0 cm proximal to patella presents a definitive defect that cannot be compensated in rat.
    Summary · context
    BPC 157 (10 microg, 10 ng, 10 pg/kg) is given intraperitoneally, once daily; the first application 30 min posttransection, the final 24 h before sacrifice.
  7. 07AnimalAnimal study (in vivo)Efficacy outcome

    In rats with transected quadriceps muscle, BPC‑157 treatment gave larger myofibril diameters on both sides, reaching normal healthy rat values.

    In plain wordsIn rats with a cut thigh muscle, BPC‑157 treatment gave thicker muscle fibers, reaching normal values.

    Peptide
    BPC-157
    Outcome
    IncreaseMyofibril diameter
    Study

    ratn: not reported in source

    Complete quadriceps muscle transection
    Outcome group
    Muscle injury and repair · Musculoskeletal
    Studied dose
    10 microg/kg, 10 ng/kg, 10 pg/kg · intraperitoneal · once daily; 72-day periodAs given in this study (rat).

    Source sentences

    Summary
    larger myofibril diameters on both sides, distal and proximal (normal healthy rat-values reached)
    2 context sentences
    Summary · context
    Regularly, quadriceps muscle completely transected transversely 1.0 cm proximal to patella presents a definitive defect that cannot be compensated in rat.
    Summary · context
    BPC 157 (10 microg, 10 ng, 10 pg/kg) is given intraperitoneally, once daily; the first application 30 min posttransection, the final 24 h before sacrifice.
  8. 08AnimalAnimal study (in vivo)Efficacy outcome

    In rats with transected quadriceps muscle, the stumps were connected with BPC‑157 treatment.

    In plain wordsIn rats with a cut thigh muscle, the cut ends were joined after BPC‑157 treatment.

    Peptide
    BPC-157
    Outcome
    IncreaseStump connection (macroscopic)
    Study

    ratn: not reported in source

    Complete quadriceps muscle transection
    Outcome group
    Muscle injury and repair · Musculoskeletal
    Studied dose
    10 microg/kg, 10 ng/kg, 10 pg/kg · intraperitoneal · once daily; 72-day periodAs given in this study (rat).

    Source sentences

    Summary
    stumps connected
    2 context sentences
    Summary · context
    Regularly, quadriceps muscle completely transected transversely 1.0 cm proximal to patella presents a definitive defect that cannot be compensated in rat.
    Summary · context
    BPC 157 (10 microg, 10 ng, 10 pg/kg) is given intraperitoneally, once daily; the first application 30 min posttransection, the final 24 h before sacrifice.
  9. 09AnimalAnimal study (in vivo)Efficacy outcome

    In rats with transected quadriceps muscle, atrophy was markedly attenuated with BPC‑157 treatment.

    In plain wordsIn rats with a cut thigh muscle, BPC‑157 treatment markedly reduced muscle wasting.

    Peptide
    BPC-157
    Outcome
    DecreaseMuscle atrophy
    Study

    ratn: not reported in source

    Complete quadriceps muscle transection
    Outcome group
    Muscle injury and repair · Musculoskeletal
    Studied dose
    10 microg/kg, 10 ng/kg, 10 pg/kg · intraperitoneal · once daily; 72-day periodAs given in this study (rat).

    Source sentences

    Summary
    atrophy markedly attenuated
    2 context sentences
    Summary · context
    Regularly, quadriceps muscle completely transected transversely 1.0 cm proximal to patella presents a definitive defect that cannot be compensated in rat.
    Summary · context
    BPC 157 (10 microg, 10 ng, 10 pg/kg) is given intraperitoneally, once daily; the first application 30 min posttransection, the final 24 h before sacrifice.
  10. 10AnimalAnimal study (in vivo)Efficacy outcome

    In rats with transected quadriceps muscle, BPC‑157 treatment gave no postsurgery leg contracture.

    In plain wordsIn rats with a cut thigh muscle, BPC‑157 treatment was followed by no stiff, shortened leg.

    Peptide
    BPC-157
    Outcome
    DecreasePost-surgery leg contracture
    Study

    ratn: not reported in source

    Complete quadriceps muscle transection
    Outcome group
    Muscle injury and repair · Musculoskeletal
    Studied dose
    10 microg/kg, 10 ng/kg, 10 pg/kg · intraperitoneal · once daily; 72-day periodAs given in this study (rat).

    Source sentences

    Summary
    no postsurgery leg contracture
    2 context sentences
    Summary · context
    Regularly, quadriceps muscle completely transected transversely 1.0 cm proximal to patella presents a definitive defect that cannot be compensated in rat.
    Summary · context
    BPC 157 (10 microg, 10 ng, 10 pg/kg) is given intraperitoneally, once daily; the first application 30 min posttransection, the final 24 h before sacrifice.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    9 Oct 2026, 18:17 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 02:56 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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