Levels of apoptosis in human granulosa cells seem to be comparable after therapy with a gonadotropin-releasing hormone agonist or antagonist.

Giampietro F, Sancilio S, Tiboni GM, Rana RA, Di Pietro R

Fertility and sterility1 Feb 2006Cited by 30 (Europe PMC)

PMID16595220DOI10.1016/j.fertnstert.2005.08.020PepBankPUB-16595220

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study11

11 results from studies that gave the peptide. 11 results from people.

01HumanRandomized controlled trialEfficacy outcome
In women undergoing assisted reproduction, triptorelin and cetrorelix regimens produced comparable granulosa cell apoptosis by Annexin V and TUNEL assays.
In plain wordsIn women undergoing assisted reproduction, triptorelin and cetrorelix regimens produced similar granulosa cell apoptosis.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
No significant changeGranulosa cell apoptosis
Study
n = 32
Comparator
Cetrorelix with recombinant FSH
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
Dose not stated
Source sentences
Summary
Annexin V binding and TUNEL assays revealed comparable percentages of apoptosis in the two groups under investigation.
3 context sentences(design, population, supporting numbers)
Summary · context
To compare levels of apoptosis in granulosa cells from women treated with the gonadotropin-releasing hormone (GnRH) agonist triptorelin or the GnRH antagonist cetrorelix.
Summary · context
Randomized, prospective study.
Summary · context
Thirty-two women undergoing assisted reproduction techniques after ovulation induction with recombinant follicle-stimulating hormone (FSH) plus GnRH agonist or antagonist.
Report a problemFND-1659522001
02HumanRandomized controlled trialEfficacy outcome
In women undergoing assisted reproduction, granulosa cell cycle distribution was similar with triptorelin and cetrorelix regimens.
In plain wordsIn women undergoing assisted reproduction, triptorelin and cetrorelix regimens produced similar granulosa cell cycle distributions.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
No significant changeGranulosa cell cycle distribution
Study
n = 32
Comparator
Cetrorelix with recombinant FSH
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
Dose not stated
Source sentences
Summary
Analysis of DNA histograms revealed a similar cell cycle distribution in the two groups.
3 context sentences(design, population, supporting numbers)
Summary · context
To compare levels of apoptosis in granulosa cells from women treated with the gonadotropin-releasing hormone (GnRH) agonist triptorelin or the GnRH antagonist cetrorelix.
Summary · context
Randomized, prospective study.
Summary · context
Thirty-two women undergoing assisted reproduction techniques after ovulation induction with recombinant follicle-stimulating hormone (FSH) plus GnRH agonist or antagonist.
Report a problemFND-1659522002
03HumanRandomized controlled trialEfficacy outcome
In women undergoing assisted reproduction, follicular fluid E2 was higher with the triptorelin regimen than with the cetrorelix regimen.
In plain wordsIn women undergoing assisted reproduction, follicular fluid E2 was higher with triptorelin than with cetrorelix.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
IncreaseFollicular fluid estradiol
Study
n = 32
Comparator
Cetrorelix with recombinant FSH
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
Dose not stated
Source sentences
Summary
The mean concentrations of all the follicular fluid steroid hormones evaluated (E2, T, and P) were significantly lower in the GnRH antagonist-treated group.
3 context sentences(design, population, supporting numbers)
Summary · context
To compare levels of apoptosis in granulosa cells from women treated with the gonadotropin-releasing hormone (GnRH) agonist triptorelin or the GnRH antagonist cetrorelix.
Summary · context
Randomized, prospective study.
Summary · context
Thirty-two women undergoing assisted reproduction techniques after ovulation induction with recombinant follicle-stimulating hormone (FSH) plus GnRH agonist or antagonist.
Report a problemFND-1659522003
04HumanRandomized controlled trialEfficacy outcome
In women undergoing assisted reproduction, follicular fluid T was higher with the triptorelin regimen than with the cetrorelix regimen.
In plain wordsIn women undergoing assisted reproduction, follicular fluid T was higher with triptorelin than with cetrorelix.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
IncreaseFollicular fluid testosterone
Study
n = 32
Comparator
Cetrorelix with recombinant FSH
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
Dose not stated
Source sentences
Summary
The mean concentrations of all the follicular fluid steroid hormones evaluated (E2, T, and P) were significantly lower in the GnRH antagonist-treated group.
3 context sentences(design, population, supporting numbers)
Summary · context
To compare levels of apoptosis in granulosa cells from women treated with the gonadotropin-releasing hormone (GnRH) agonist triptorelin or the GnRH antagonist cetrorelix.
Summary · context
Randomized, prospective study.
Summary · context
Thirty-two women undergoing assisted reproduction techniques after ovulation induction with recombinant follicle-stimulating hormone (FSH) plus GnRH agonist or antagonist.
Report a problemFND-1659522004
05HumanRandomized controlled trialEfficacy outcome
In women undergoing assisted reproduction, follicular fluid P was higher with the triptorelin regimen than with the cetrorelix regimen.
In plain wordsIn women undergoing assisted reproduction, follicular fluid P was higher with triptorelin than with cetrorelix.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
IncreaseFollicular fluid progesterone
Study
n = 32
Comparator
Cetrorelix with recombinant FSH
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
Dose not stated
Source sentences
Summary
The mean concentrations of all the follicular fluid steroid hormones evaluated (E2, T, and P) were significantly lower in the GnRH antagonist-treated group.
3 context sentences(design, population, supporting numbers)
Summary · context
To compare levels of apoptosis in granulosa cells from women treated with the gonadotropin-releasing hormone (GnRH) agonist triptorelin or the GnRH antagonist cetrorelix.
Summary · context
Randomized, prospective study.
Summary · context
Thirty-two women undergoing assisted reproduction techniques after ovulation induction with recombinant follicle-stimulating hormone (FSH) plus GnRH agonist or antagonist.
Report a problemFND-1659522005
06HumanRandomized controlled trialEfficacy outcome
In women undergoing assisted reproduction, cetrorelix and triptorelin groups had comparable granulosa-cell apoptosis percentages by Annexin V binding.
In plain wordsIn women undergoing assisted reproduction, cetrorelix and triptorelin groups had similar cell death percentages by Annexin V binding.
Peptide
Cetrorelix
Outcome
Direction not reportedApoptosis by Annexin V binding
Study
n = 32
Comparator
Triptorelin
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
Dose not stated
Source sentences
Summary
Annexin V binding and TUNEL assays revealed comparable percentages of apoptosis in the two groups under investigation.
3 context sentences(design, population, supporting numbers)
Summary · context
To compare levels of apoptosis in granulosa cells from women treated with the gonadotropin-releasing hormone (GnRH) agonist triptorelin or the GnRH antagonist cetrorelix.
Summary · context
Randomized, prospective study.
Summary · context
Thirty-two women undergoing assisted reproduction techniques after ovulation induction with recombinant follicle-stimulating hormone (FSH) plus GnRH agonist or antagonist.
Report a problemFND-1659522006
07HumanRandomized controlled trialEfficacy outcome
In women undergoing assisted reproduction, cetrorelix and triptorelin groups had comparable granulosa-cell apoptosis percentages by TUNEL assay.
In plain wordsIn women undergoing assisted reproduction, cetrorelix and triptorelin groups had similar cell death percentages by TUNEL assay.
Peptide
Cetrorelix
Outcome
Direction not reportedApoptosis by TUNEL assay
Study
n = 32
Comparator
Triptorelin
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
Dose not stated
Source sentences
Summary
Annexin V binding and TUNEL assays revealed comparable percentages of apoptosis in the two groups under investigation.
3 context sentences(design, population, supporting numbers)
Summary · context
To compare levels of apoptosis in granulosa cells from women treated with the gonadotropin-releasing hormone (GnRH) agonist triptorelin or the GnRH antagonist cetrorelix.
Summary · context
Randomized, prospective study.
Summary · context
Thirty-two women undergoing assisted reproduction techniques after ovulation induction with recombinant follicle-stimulating hormone (FSH) plus GnRH agonist or antagonist.
Report a problemFND-1659522007
08HumanRandomized controlled trialMechanism
In women undergoing assisted reproduction, cetrorelix and triptorelin groups had similar granulosa-cell cycle distributions on DNA histograms.
In plain wordsIn women undergoing assisted reproduction, cetrorelix and triptorelin groups had similar cell cycle distributions.
Peptide
Cetrorelix
Outcome
Direction not reportedCell cycle distribution
Study
n = 32
Comparator
Triptorelin
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
Dose not stated
Source sentences
Summary
Analysis of DNA histograms revealed a similar cell cycle distribution in the two groups.
3 context sentences(design, population, supporting numbers)
Summary · context
To compare levels of apoptosis in granulosa cells from women treated with the gonadotropin-releasing hormone (GnRH) agonist triptorelin or the GnRH antagonist cetrorelix.
Summary · context
Randomized, prospective study.
Summary · context
Thirty-two women undergoing assisted reproduction techniques after ovulation induction with recombinant follicle-stimulating hormone (FSH) plus GnRH agonist or antagonist.
Report a problemFND-1659522008
09HumanRandomized controlled trialEfficacy outcome
In women undergoing assisted reproduction, follicular fluid E2 concentrations were significantly lower with cetrorelix than with triptorelin.
In plain wordsIn women undergoing assisted reproduction, follicular fluid E2 levels were significantly lower with cetrorelix than with triptorelin.
Peptide
Cetrorelix
Outcome
DecreaseFollicular fluid E2 concentration
Study
n = 32
Comparator
Triptorelin
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
Dose not stated
Source sentences
Summary
The mean concentrations of all the follicular fluid steroid hormones evaluated (E2, T, and P) were significantly lower in the GnRH antagonist-treated group.
3 context sentences(design, population, supporting numbers)
Summary · context
To compare levels of apoptosis in granulosa cells from women treated with the gonadotropin-releasing hormone (GnRH) agonist triptorelin or the GnRH antagonist cetrorelix.
Summary · context
Randomized, prospective study.
Summary · context
Thirty-two women undergoing assisted reproduction techniques after ovulation induction with recombinant follicle-stimulating hormone (FSH) plus GnRH agonist or antagonist.
Report a problemFND-1659522009
10HumanRandomized controlled trialEfficacy outcome
In women undergoing assisted reproduction, follicular fluid T concentrations were significantly lower with cetrorelix than with triptorelin.
In plain wordsIn women undergoing assisted reproduction, follicular fluid T levels were significantly lower with cetrorelix than with triptorelin.
Peptide
Cetrorelix
Outcome
DecreaseFollicular fluid T concentration
Study
n = 32
Comparator
Triptorelin
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
Dose not stated
Source sentences
Summary
The mean concentrations of all the follicular fluid steroid hormones evaluated (E2, T, and P) were significantly lower in the GnRH antagonist-treated group.
3 context sentences(design, population, supporting numbers)
Summary · context
To compare levels of apoptosis in granulosa cells from women treated with the gonadotropin-releasing hormone (GnRH) agonist triptorelin or the GnRH antagonist cetrorelix.
Summary · context
Randomized, prospective study.
Summary · context
Thirty-two women undergoing assisted reproduction techniques after ovulation induction with recombinant follicle-stimulating hormone (FSH) plus GnRH agonist or antagonist.
Report a problemFND-1659522010
11HumanRandomized controlled trialEfficacy outcome
In women undergoing assisted reproduction, follicular fluid P concentrations were significantly lower with cetrorelix than with triptorelin.
In plain wordsIn women undergoing assisted reproduction, follicular fluid P levels were significantly lower with cetrorelix than with triptorelin.
Peptide
Cetrorelix
Outcome
DecreaseFollicular fluid P concentration
Study
n = 32
Comparator
Triptorelin
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
Dose not stated
Source sentences
Summary
The mean concentrations of all the follicular fluid steroid hormones evaluated (E2, T, and P) were significantly lower in the GnRH antagonist-treated group.
3 context sentences(design, population, supporting numbers)
Summary · context
To compare levels of apoptosis in granulosa cells from women treated with the gonadotropin-releasing hormone (GnRH) agonist triptorelin or the GnRH antagonist cetrorelix.
Summary · context
Randomized, prospective study.
Summary · context
Thirty-two women undergoing assisted reproduction techniques after ovulation induction with recombinant follicle-stimulating hormone (FSH) plus GnRH agonist or antagonist.
Report a problemFND-1659522011

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 3Current
27 Oct 2026, 16:35 UTC
Study data updated · source update from Europe PMC
Version 2
22 Oct 2026, 02:26 UTC
Study results updated
Version 1
21 Oct 2026, 18:59 UTC
First added · source update from Europe PMC

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Levels of apoptosis in human granulosa cells seem to be comparable after therapy with a gonadotropin-releasing hormone agonist or antagonist.

Summary

Results from this study11

Version history

Subjects

Publication types

MeSH terms