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Study · Animal study (in vivo) · rat · 2006

9 results

Achilles detachment in rat and stable gastric pentadecapeptide BPC 157: Promoted tendon-to-bone healing and opposed corticosteroid aggravation.

Krivic A, Anic T, Seiwerth S, Huljev D, Sikiric P

Journal of orthopaedic research : official publication of the Orthopaedic Research Society1 May 2006Cited by 45 (Europe PMC)

PMID16583442 (opens in a new tab)DOI10.1002/jor.20096 (opens in a new tab)PepBankPUB-16583442
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study9

9 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats with Achilles tendon detached from bone, BPC‑157 improved healing functionally, with substantially increased Achilles functional index values.

    In plain wordsIn rats with a detached Achilles tendon, BPC‑157 improved how well the tendon worked.

    Peptide
    BPC-157
    Outcome
    IncreaseAchilles functional index (AFI)
    Study

    ratn: not reported in source

    Achilles tendon detachment from calcaneal bone
    Outcome group
    Tendon and ligament healing · Musculoskeletal
    Studied dose
    10 microg/kg, 10 ng/kg, 10 pg/kg · intraperitoneal · once daily; tested at days 1 to 21As given in this study (rat).

    Source sentences

    Summary
    functionally [Achilles functional index (AFI) values substantially increased]
    1 context sentence
    Summary · context
    After the rat's Achilles tendon was sharply transected from calcaneal bone, agents [BPC 157 (10 microg, 10 ng, 10 pg), 6alpha-methylprednisolone (1 mg), 0.9% NaCl (5 mL)] were given alone or in combination [/kg body weight (b.w.) intraperitoneally, once time daily, first 30-min after surgery, last 2…
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats with Achilles tendon detached from bone, BPC‑157 significantly increased load to failure.

    In plain wordsIn rats with a detached Achilles tendon, BPC‑157 increased the load the healed tendon could bear.

    Peptide
    BPC-157
    Outcome
    IncreaseLoad to failure
    Study

    ratn: not reported in source

    Achilles tendon detachment from calcaneal bone
    Outcome group
    Tendon and ligament healing · Musculoskeletal
    Studied dose
    10 microg/kg, 10 ng/kg, 10 pg/kg · intraperitoneal · once daily; tested at days 1 to 21As given in this study (rat).

    Source sentences

    Summary
    biomechanically (load to failure, stiffness, and Young elasticity modulus significantly increased)
    1 context sentence
    Summary · context
    After the rat's Achilles tendon was sharply transected from calcaneal bone, agents [BPC 157 (10 microg, 10 ng, 10 pg), 6alpha-methylprednisolone (1 mg), 0.9% NaCl (5 mL)] were given alone or in combination [/kg body weight (b.w.) intraperitoneally, once time daily, first 30-min after surgery, last 2…
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In rats with Achilles tendon detached from bone, BPC‑157 significantly increased stiffness.

    In plain wordsIn rats with a detached Achilles tendon, BPC‑157 increased the stiffness of the healed tendon.

    Peptide
    BPC-157
    Outcome
    IncreaseStiffness
    Study

    ratn: not reported in source

    Achilles tendon detachment from calcaneal bone
    Outcome group
    Tendon and ligament healing · Musculoskeletal
    Studied dose
    10 microg/kg, 10 ng/kg, 10 pg/kg · intraperitoneal · once daily; tested at days 1 to 21As given in this study (rat).

    Source sentences

    Summary
    biomechanically (load to failure, stiffness, and Young elasticity modulus significantly increased)
    1 context sentence
    Summary · context
    After the rat's Achilles tendon was sharply transected from calcaneal bone, agents [BPC 157 (10 microg, 10 ng, 10 pg), 6alpha-methylprednisolone (1 mg), 0.9% NaCl (5 mL)] were given alone or in combination [/kg body weight (b.w.) intraperitoneally, once time daily, first 30-min after surgery, last 2…
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In rats with Achilles tendon detached from bone, BPC‑157 significantly increased the Young elasticity modulus.

    In plain wordsIn rats with a detached Achilles tendon, BPC‑157 increased a measure of how elastic the healed tendon was.

    Peptide
    BPC-157
    Outcome
    IncreaseYoung elasticity modulus
    Study

    ratn: not reported in source

    Achilles tendon detachment from calcaneal bone
    Outcome group
    Tendon and ligament healing · Musculoskeletal
    Studied dose
    10 microg/kg, 10 ng/kg, 10 pg/kg · intraperitoneal · once daily; tested at days 1 to 21As given in this study (rat).

    Source sentences

    Summary
    biomechanically (load to failure, stiffness, and Young elasticity modulus significantly increased)
    1 context sentence
    Summary · context
    After the rat's Achilles tendon was sharply transected from calcaneal bone, agents [BPC 157 (10 microg, 10 ng, 10 pg), 6alpha-methylprednisolone (1 mg), 0.9% NaCl (5 mL)] were given alone or in combination [/kg body weight (b.w.) intraperitoneally, once time daily, first 30-min after surgery, last 2…
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In rats with Achilles tendon detached from bone, BPC‑157 improved healing macro/microscopically.

    In plain wordsIn rats with a detached Achilles tendon, BPC‑157 improved healing seen by eye and under the microscope.

    Peptide
    BPC-157
    Outcome
    IncreaseMacroscopic and microscopic healing
    Study

    ratn: not reported in source

    Achilles tendon detachment from calcaneal bone
    Outcome group
    Tendon and ligament healing · Musculoskeletal
    Studied dose
    10 microg/kg, 10 ng/kg, 10 pg/kg · intraperitoneal · once daily; tested at days 1 to 21As given in this study (rat).

    Source sentences

    Summary
    macro/microscopically
    1 context sentence
    Summary · context
    After the rat's Achilles tendon was sharply transected from calcaneal bone, agents [BPC 157 (10 microg, 10 ng, 10 pg), 6alpha-methylprednisolone (1 mg), 0.9% NaCl (5 mL)] were given alone or in combination [/kg body weight (b.w.) intraperitoneally, once time daily, first 30-min after surgery, last 2…
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In rats with Achilles tendon detached from bone, BPC‑157 gave better organization of collagen fibers on immunohistochemistry.

    In plain wordsIn rats with a detached Achilles tendon, BPC‑157 gave better organized collagen fibers.

    Peptide
    BPC-157
    Outcome
    IncreaseCollagen fiber organization
    Study

    ratn: not reported in source

    Achilles tendon detachment from calcaneal bone
    Outcome group
    Tendon and ligament healing · Musculoskeletal
    Studied dose
    10 microg/kg, 10 ng/kg, 10 pg/kg · intraperitoneal · once daily; tested at days 1 to 21As given in this study (rat).

    Source sentences

    Summary
    better organization of collagen fibers
    1 context sentence
    Summary · context
    After the rat's Achilles tendon was sharply transected from calcaneal bone, agents [BPC 157 (10 microg, 10 ng, 10 pg), 6alpha-methylprednisolone (1 mg), 0.9% NaCl (5 mL)] were given alone or in combination [/kg body weight (b.w.) intraperitoneally, once time daily, first 30-min after surgery, last 2…
  7. 07AnimalAnimal study (in vivo)Efficacy outcome

    In rats with Achilles tendon detached from bone, BPC‑157 gave an advanced vascular appearance on immunohistochemistry.

    In plain wordsIn rats with a detached Achilles tendon, BPC‑157 gave a more advanced blood vessel appearance.

    Peptide
    BPC-157
    Outcome
    IncreaseVascular appearance
    Study

    ratn: not reported in source

    Achilles tendon detachment from calcaneal bone
    Outcome group
    Tendon and ligament healing · Musculoskeletal
    Studied dose
    10 microg/kg, 10 ng/kg, 10 pg/kg · intraperitoneal · once daily; tested at days 1 to 21As given in this study (rat).

    Source sentences

    Summary
    advanced vascular appearance
    1 context sentence
    Summary · context
    After the rat's Achilles tendon was sharply transected from calcaneal bone, agents [BPC 157 (10 microg, 10 ng, 10 pg), 6alpha-methylprednisolone (1 mg), 0.9% NaCl (5 mL)] were given alone or in combination [/kg body weight (b.w.) intraperitoneally, once time daily, first 30-min after surgery, last 2…
  8. 08AnimalAnimal study (in vivo)Efficacy outcome

    In rats with Achilles tendon detached from bone, BPC‑157 gave more collagen type I on immunohistochemistry.

    In plain wordsIn rats with a detached Achilles tendon, BPC‑157 gave more collagen type I.

    Peptide
    BPC-157
    Outcome
    IncreaseCollagen type I
    Study

    ratn: not reported in source

    Achilles tendon detachment from calcaneal bone
    Outcome group
    Tendon and ligament healing · Musculoskeletal
    Studied dose
    10 microg/kg, 10 ng/kg, 10 pg/kg · intraperitoneal · once daily; tested at days 1 to 21As given in this study (rat).

    Source sentences

    Summary
    more collagen type I
    1 context sentence
    Summary · context
    After the rat's Achilles tendon was sharply transected from calcaneal bone, agents [BPC 157 (10 microg, 10 ng, 10 pg), 6alpha-methylprednisolone (1 mg), 0.9% NaCl (5 mL)] were given alone or in combination [/kg body weight (b.w.) intraperitoneally, once time daily, first 30-min after surgery, last 2…
  9. 09AnimalAnimal study (in vivo)Efficacy outcome

    In rats with Achilles tendon detached from bone, BPC‑157 substantially reduced the aggravation of healing caused by 6alpha-methylprednisolone.

    In plain wordsIn rats with a detached Achilles tendon, BPC‑157 reduced the healing damage caused by a corticosteroid.

    Peptide
    BPC-157
    Outcome
    DecreaseMethylprednisolone-aggravated healing
    Study

    ratn: not reported in source

    Achilles tendon detachment from calcaneal bone
    Comparator
    6alpha-methylprednisolone alone
    Outcome group
    Tendon and ligament healing · Musculoskeletal
    Studied dose
    10 microg/kg, 10 ng/kg, 10 pg/kg · intraperitoneal · once daily; tested at days 1 to 21As given in this study (rat).

    Source sentences

    Summary
    BPC 157 substantially reduces 6alpha-methylprednisolone healing aggravation
    1 context sentence
    Summary · context
    After the rat's Achilles tendon was sharply transected from calcaneal bone, agents [BPC 157 (10 microg, 10 ng, 10 pg), 6alpha-methylprednisolone (1 mg), 0.9% NaCl (5 mL)] were given alone or in combination [/kg body weight (b.w.) intraperitoneally, once time daily, first 30-min after surgery, last 2…

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    9 Oct 2026, 18:17 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 02:56 UTC

    First added · source update from Europe PMC

Subjects

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