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Study · Animal study (in vivo) · rat · 2006

9 results

Hypothalamic expression of KiSS-1 system and gonadotropin-releasing effects of kisspeptin in different reproductive states of the female Rat.

Roa J, Vigo E, Castellano JM, Navarro VM, Fernández-Fernández R, Casanueva FF, Dieguez C, Aguilar E, Pinilla L, Tena-Sempere M

Endocrinology9 Mar 2006Cited by 140 (Europe PMC)

PMID16527840 (opens in a new tab)DOI10.1210/en.2005-1463 (opens in a new tab)PepBankPUB-16527840
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study9

7 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In adult female rats, kisspeptin‑10 elicited robust LH bursts at all phases of the estrous cycle, with maximal responses at estrus.

    In plain wordsIn female rats, kisspeptin‑10 caused strong LH surges at every stage of the cycle, strongest at estrus.

    Peptide
    Kisspeptin-10
    Outcome
    IncreaseLH bursts across the estrous cycle
    Study

    ratn: not reported in source

    Adult female rat
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    1 nmol · intracerebroventricularAs given in this study (rat).

    Source sentences

    Summary
    was able to elicit robust LH bursts at all phases of the estrous cycle, with maximal responses at estrus
    1 context sentence
    Summary · context
    In this work, we evaluated maximal LH and FSH secretory responses to kisspeptin-10, as well as changes in sensitivity and hypothalamic expression of KiSS-1 and GPR54 genes, in different physiological and experimental models in the adult female rat.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In diestrus adult female rats, LH responses to kisspeptin‑10 were detected at doses as low as 0.1 pmol.

    In plain wordsIn female rats at one stage of the cycle, even a very small dose of kisspeptin‑10 raised LH.

    Peptide
    Kisspeptin-10
    Outcome
    IncreaseLH sensitivity to kisspeptin-10 in diestrus
    Study

    ratn: not reported in source

    Adult female rat
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    as low as 0.1 pmol · intracerebroventricularAs given in this study (rat).

    Source sentences

    Summary
    in diestrus LH, responses to kisspeptin were detected at doses as low as 0.1 pmol.
    1 context sentence
    Summary · context
    In this work, we evaluated maximal LH and FSH secretory responses to kisspeptin-10, as well as changes in sensitivity and hypothalamic expression of KiSS-1 and GPR54 genes, in different physiological and experimental models in the adult female rat.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In adult female rats, high doses of kisspeptin stimulated FSH secretion only at diestrus.

    In plain wordsIn female rats, high doses of kisspeptin raised FSH only at one stage of the cycle.

    Peptide
    Kisspeptin-10
    Outcome
    IncreaseFSH secretion by high-dose kisspeptin
    Study

    ratn: not reported in source

    Adult female rat
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In contrast, high doses of kisspeptin only stimulated FSH secretion at diestrus.
    1 context sentence
    Summary · context
    In this work, we evaluated maximal LH and FSH secretory responses to kisspeptin-10, as well as changes in sensitivity and hypothalamic expression of KiSS-1 and GPR54 genes, in different physiological and experimental models in the adult female rat.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In ovariectomized female rats, removal of ovarian sex steroids did not blunt kisspeptin-stimulated LH and FSH secretion.

    In plain wordsIn female rats without ovaries, kisspeptin still raised LH and FSH.

    Peptide
    Kisspeptin-10
    Outcome
    No significant changeLH and FSH response after removal of ovarian steroids
    Study

    ratn: not reported in source

    Adult female rat
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Removal of ovarian sex steroids did not blunt the ability of kisspeptin to further elicit stimulated LH and FSH secretion
    1 context sentence
    Summary · context
    In this work, we evaluated maximal LH and FSH secretory responses to kisspeptin-10, as well as changes in sensitivity and hypothalamic expression of KiSS-1 and GPR54 genes, in different physiological and experimental models in the adult female rat.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In ovariectomized female rats, restoration of maximal responses to kisspeptin required replacement with estradiol and progesterone.

    In plain wordsIn female rats without ovaries, the full response to kisspeptin returned only when estradiol and progesterone were given back.

    Peptide
    Kisspeptin-10
    Outcome
    IncreaseMaximal LH and FSH response with estradiol and progesterone replacement
    Study

    ratn: not reported in source

    Adult female rat
    Comparator
    Ovariectomy without replacement
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    but restoration of maximal responses required replacement with estradiol and progesterone.
    1 context sentence
    Summary · context
    In this work, we evaluated maximal LH and FSH secretory responses to kisspeptin-10, as well as changes in sensitivity and hypothalamic expression of KiSS-1 and GPR54 genes, in different physiological and experimental models in the adult female rat.
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In pregnant and lactating female rats, LH and FSH responses to kisspeptin were preserved despite suppressed basal levels.

    In plain wordsIn pregnant and nursing female rats, kisspeptin still raised LH and FSH.

    Peptide
    Kisspeptin-10
    Outcome
    No significant changeLH and FSH responses in pregnant and lactating rats
    Study

    ratn: not reported in source

    Adult female rat
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Finally, despite suppressed basal levels, LH and FSH secretory responses to kisspeptin were preserved in pregnant and lactating females
    1 context sentence
    Summary · context
    In this work, we evaluated maximal LH and FSH secretory responses to kisspeptin-10, as well as changes in sensitivity and hypothalamic expression of KiSS-1 and GPR54 genes, in different physiological and experimental models in the adult female rat.
  7. 07AnimalAnimal study (in vivo)Efficacy outcome

    In female rats, the magnitude of LH bursts and the sensitivity to kisspeptin were much higher in pregnant dams.

    In plain wordsIn female rats, pregnant animals gave bigger LH surges and reacted to smaller kisspeptin doses than other animals.

    Peptide
    Kisspeptin-10
    Outcome
    IncreaseLH burst magnitude and sensitivity in pregnant dams
    Study

    ratn: not reported in source

    Adult female rat
    Comparator
    Other reproductive states
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    although the magnitude of LH bursts and the sensitivity to kisspeptin were much higher in pregnant dams.
    1 context sentence
    Summary · context
    In this work, we evaluated maximal LH and FSH secretory responses to kisspeptin-10, as well as changes in sensitivity and hypothalamic expression of KiSS-1 and GPR54 genes, in different physiological and experimental models in the adult female rat.

Natural levels measured2

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 08AnimalEndogenous levelAnimal study (in vivo)Mechanism

    In female rats, hypothalamic KiSS-1 gene expression significantly increased during pregnancy.

    In plain wordsIn female rats, the body's own kisspeptin gene became more active in the brain during pregnancy.

    Peptide
    Kisspeptin-10
    Outcome
    IncreaseHypothalamic KiSS-1 expression in pregnancy
    Study

    ratn: not reported in source

    Adult female rat
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health

    Source sentences

    Summary
    Interestingly, hypothalamic KiSS-1 gene expression significantly increased during pregnancy
    1 context sentence
    Summary · context
    In this work, we evaluated maximal LH and FSH secretory responses to kisspeptin-10, as well as changes in sensitivity and hypothalamic expression of KiSS-1 and GPR54 genes, in different physiological and experimental models in the adult female rat.

    This result measures the body's own Kisspeptin-10. Nobody was given the peptide. It is not evidence about taking it.

  2. 09AnimalEndogenous levelAnimal study (in vivo)Mechanism

    In female rats, hypothalamic GPR54 mRNA levels remained unaltered during pregnancy.

    In plain wordsIn female rats, the body's own kisspeptin receptor gene did not change in the brain during pregnancy.

    Peptide
    Kisspeptin-10
    Outcome
    No significant changeHypothalamic GPR54 mRNA in pregnancy
    Study

    ratn: not reported in source

    Adult female rat
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health

    Source sentences

    Summary
    Interestingly, hypothalamic KiSS-1 gene expression significantly increased during pregnancy, whereas GPR54 mRNA levels remained unaltered.
    1 context sentence
    Summary · context
    In this work, we evaluated maximal LH and FSH secretory responses to kisspeptin-10, as well as changes in sensitivity and hypothalamic expression of KiSS-1 and GPR54 genes, in different physiological and experimental models in the adult female rat.

    This result measures the body's own Kisspeptin-10. Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 09:43 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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