Effects of single or repeated intravenous administration of kisspeptin upon dynamic LH secretion in conscious male rats.

Tovar S, Vázquez MJ, Navarro VM, Fernández-Fernández R, Castellano JM, Vigo E, Roa J, Casanueva FF, Aguilar E, Pinilla L, Dieguez C, Tena-Sempere M

Endocrinology2 Mar 2006Cited by 81 (Europe PMC)

PMID16513831DOI10.1210/en.2005-1397PepBankPUB-16513831

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

8 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In conscious male rats, intravenous kisspeptin‑10 at doses as low as 0.3 nmol/kg evoked robust LH bursts.
In plain wordsIn rats, very low intravenous doses of kisspeptin‑10 triggered strong LH bursts.
Peptide
Kisspeptin-10
Outcome
IncreaseLH burst at low dose
Study
ratn: not reported in source
conscious, freely moving male rats
Outcome group
Sex hormones and fertility · Endocrine and hormones
Studied dose
0.3 nmol/kg · intravenousAs given in this study (rat).
Measurements
lowest effective dose
0.3 nmol/kg
kisspeptin-10
Source sentences
Summary
LH responsiveness to peripheral administration of kisspeptin appeared extremely sensitive, as doses as low as 0.3 nmol/kg (0.1 microg/rat) evoked robust LH bursts, the magnitude of which was dose-dependent and apparently maximal in response to 3.0 and 30 nmol/kg kisspeptin-10.
1 context sentence(design, population, supporting numbers)
Summary · context
In this study, dynamic LH secretory responses to iv administration of kisspeptin-10 in different experimental settings are presented, and compared with those evoked by kisspeptin-52, using a protocol of serial blood sampling in conscious, freely moving male rats.
Report a problemFND-1651383101
02AnimalAnimal study (in vivo)Efficacy outcome
In conscious male rats, the LH burst after intravenous kisspeptin‑10 was dose-dependent and apparently maximal at 3.0 and 30 nmol/kg.
In plain wordsIn rats, bigger kisspeptin‑10 doses gave bigger LH bursts, with the largest response at 3.0 and 30 nmol/kg.
Peptide
Kisspeptin-10
Outcome
IncreaseDose dependence of LH burst magnitude
Study
ratn: not reported in source
conscious, freely moving male rats
Outcome group
Sex hormones and fertility · Endocrine and hormones
Studied dose
0.3 to 30 nmol/kg · intravenousAs given in this study (rat).
Source sentences
Summary
LH responsiveness to peripheral administration of kisspeptin appeared extremely sensitive, as doses as low as 0.3 nmol/kg (0.1 microg/rat) evoked robust LH bursts, the magnitude of which was dose-dependent and apparently maximal in response to 3.0 and 30 nmol/kg kisspeptin-10.
1 context sentence(design, population, supporting numbers)
Summary · context
In this study, dynamic LH secretory responses to iv administration of kisspeptin-10 in different experimental settings are presented, and compared with those evoked by kisspeptin-52, using a protocol of serial blood sampling in conscious, freely moving male rats.
Report a problemFND-1651383102
03AnimalAnimal study (in vivo)Efficacy outcome
In conscious male rats, the LH response to kisspeptin‑10 was preserved after short-term fasting and doubled in relative terms, despite lower baseline LH.
In plain wordsIn rats, kisspeptin‑10 still raised LH after a short fast, and the relative rise was twice as large.
Peptide
Kisspeptin-10
Outcome
IncreaseLH response to kisspeptin-10 after short-term fasting
Study
ratn: not reported in source
conscious, freely moving male rats
Outcome group
Sex hormones and fertility · Endocrine and hormones
Studied dose
Dose not stated · intravenousAs given in this study (rat).
Source sentences
Summary
The ability of kisspeptin-10 to stimulate LH release was fully preserved, and even doubled in terms of relative increases, after short-term fasting despite suppression of prevailing LH levels.
1 context sentence(design, population, supporting numbers)
Summary · context
In this study, dynamic LH secretory responses to iv administration of kisspeptin-10 in different experimental settings are presented, and compared with those evoked by kisspeptin-52, using a protocol of serial blood sampling in conscious, freely moving male rats.
Report a problemFND-1651383103
04AnimalAnimal study (in vivo)Efficacy outcome
In conscious male rats, four repeated kisspeptin‑10 boluses at 75-min intervals evoked LH pulses of constant magnitude.
In plain wordsIn rats, repeated kisspeptin‑10 injections gave LH pulses of the same size each time.
Peptide
Kisspeptin-10
Outcome
No significant changeLH pulse magnitude with repeated kisspeptin-10 injections
Study
ratn: not reported in source
conscious, freely moving male rats
Outcome group
Sex hormones and fertility · Endocrine and hormones
Studied dose
Dose not stated · intravenous · four boluses at 75-min intervalsAs given in this study (rat).
Source sentences
Summary
Repeated injections of kisspeptin-10 (four boluses, at 75-min intervals) evoked associated LH secretory pulses, the magnitude of which remained constant along the study period.
1 context sentence(design, population, supporting numbers)
Summary · context
In this study, dynamic LH secretory responses to iv administration of kisspeptin-10 in different experimental settings are presented, and compared with those evoked by kisspeptin-52, using a protocol of serial blood sampling in conscious, freely moving male rats.
Report a problemFND-1651383104
05AnimalAnimal study (in vivo)Efficacy outcome
In male rats given repeated kisspeptin‑10, the in vivo LH response to a terminal GnRH injection was preserved.
In plain wordsIn rats given repeated kisspeptin‑10, the LH response to a GnRH injection stayed intact.
Peptide
Kisspeptin-10
Outcome
No significant changeLH response to GnRH after repeated kisspeptin-10
Study
ratn: not reported in source
conscious, freely moving male rats
Outcome group
Sex hormones and fertility · Endocrine and hormones
Studied dose
Dose not stated · intravenousAs given in this study (rat).
Source sentences
Summary
in vivo LH responses to a terminal injection of GnRH were preserved
2 context sentences(design, population, supporting numbers)
Summary · context
Repeated injections of kisspeptin-10 (four boluses, at 75-min intervals) evoked associated LH secretory pulses, the magnitude of which remained constant along the study period.
Summary · context
In this study, dynamic LH secretory responses to iv administration of kisspeptin-10 in different experimental settings are presented, and compared with those evoked by kisspeptin-52, using a protocol of serial blood sampling in conscious, freely moving male rats.
Report a problemFND-1651383105
06AnimalAnimal study (in vivo)Efficacy outcome
In male rats given repeated kisspeptin‑10, basal GnRH release measured ex vivo was significantly enhanced.
In plain wordsIn rats given repeated kisspeptin‑10, tissue taken afterwards released more GnRH at baseline.
Peptide
Kisspeptin-10
Outcome
IncreaseBasal GnRH release ex vivo after repeated kisspeptin-10
Study
ratn: not reported in source
conscious, freely moving male rats
Outcome group
Sex hormones and fertility · Endocrine and hormones
Studied dose
Dose not stated · intravenousAs given in this study (rat).
Source sentences
Summary
basal and depolarization-induced GnRH release ex vivo was significantly enhanced.
2 context sentences(design, population, supporting numbers)
Summary · context
Repeated injections of kisspeptin-10 (four boluses, at 75-min intervals) evoked associated LH secretory pulses, the magnitude of which remained constant along the study period.
Summary · context
In this study, dynamic LH secretory responses to iv administration of kisspeptin-10 in different experimental settings are presented, and compared with those evoked by kisspeptin-52, using a protocol of serial blood sampling in conscious, freely moving male rats.
Report a problemFND-1651383106
07AnimalAnimal study (in vivo)Efficacy outcome
In male rats given repeated kisspeptin‑10, depolarization-induced GnRH release measured ex vivo was significantly enhanced.
In plain wordsIn rats given repeated kisspeptin‑10, tissue taken afterwards released more GnRH when stimulated.
Peptide
Kisspeptin-10
Outcome
IncreaseDepolarization-induced GnRH release ex vivo after repeated kisspeptin-10
Study
ratn: not reported in source
conscious, freely moving male rats
Outcome group
Sex hormones and fertility · Endocrine and hormones
Studied dose
Dose not stated · intravenousAs given in this study (rat).
Source sentences
Summary
basal and depolarization-induced GnRH release ex vivo was significantly enhanced.
2 context sentences(design, population, supporting numbers)
Summary · context
Repeated injections of kisspeptin-10 (four boluses, at 75-min intervals) evoked associated LH secretory pulses, the magnitude of which remained constant along the study period.
Summary · context
In this study, dynamic LH secretory responses to iv administration of kisspeptin-10 in different experimental settings are presented, and compared with those evoked by kisspeptin-52, using a protocol of serial blood sampling in conscious, freely moving male rats.
Report a problemFND-1651383107
08AnimalAnimal study (in vivo)Efficacy outcome
In conscious male rats, intravenous kisspeptin‑10 evoked LH responses analogous to kisspeptin-52, but of slightly smaller net magnitude and duration.
In plain wordsIn rats, kisspeptin‑10 raised LH in a similar way to kisspeptin-52, but slightly less strongly and for a shorter time.
Peptide
Kisspeptin-10
Outcome
DecreaseLH response magnitude and duration versus kisspeptin-52
Study
ratn: not reported in source
conscious, freely moving male rats
Comparator
kisspeptin-52
Outcome group
Sex hormones and fertility · Endocrine and hormones
Studied dose
Dose not stated · intravenousAs given in this study (rat).
Source sentences
Summary
Finally, iv administration of kisspeptin-52 elicited dynamic LH responses analogous to that of kisspeptin-10; yet, their net magnitude and duration was slightly greater.
1 context sentence(design, population, supporting numbers)
Summary · context
In this study, dynamic LH secretory responses to iv administration of kisspeptin-10 in different experimental settings are presented, and compared with those evoked by kisspeptin-52, using a protocol of serial blood sampling in conscious, freely moving male rats.
Report a problemFND-1651383108

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PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
10 Oct 2026, 09:43 UTC
Study results updated
Version 1
9 Oct 2026, 03:04 UTC
First added · source update from Europe PMC

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