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Study · Animal study (in vivo) · rhesus monkey (macaca mulatta) · 2006

3 results

Continuous human metastin 45-54 infusion desensitizes G protein-coupled receptor 54-induced gonadotropin-releasing hormone release monitored indirectly in the juvenile male Rhesus monkey (Macaca mulatta): a finding with therapeutic implications.

Seminara SB, Dipietro MJ, Ramaswamy S, Crowley WF Jr, Plant TM

Endocrinology9 Feb 2006Cited by 161 (Europe PMC)

PMID16469799 (opens in a new tab)DOI10.1210/en.2005-1550 (opens in a new tab)PepBankPUB-16469799
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In juvenile male monkeys, a bolus then continuous infusion of human metastin 45-54 elicited a brisk LH response for approximately 3 h.

    In plain wordsIn monkeys, a continuous infusion of metastin 45-54 (kisspeptin‑10) triggered a strong LH rise lasting about 3 hours.

    Peptide
    Kisspeptin-10
    Outcome
    IncreaseLH response to continuous metastin 45-54 infusion
    Study

    rhesus monkey (Macaca mulatta)n = 3

    agonadal juvenile male monkeys primed with pulsatile GnRH
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    10 µg bolus then 100 µg/h infusionAs given in this study (rhesus monkey (Macaca mulatta)).

    Source sentences

    Summary
    After bolus injection of 10 microg human (hu) metastin 45-54 (equivalent to kisspeptin 112-121), the GPR54 agonist was infused continuously at a dose of 100 microg/h and elicited a brisk LH response for approximately 3 h.
    1 context sentence
    Summary · context
    The effect of continuous administration of the C-terminal fragment of metastin, the ligand for the G protein-coupled receptor, GPR54, on GnRH-induced LH secretion was examined in three agonadal, juvenile male monkeys whose responsiveness to GnRH was heightened by pretreatment with a chronic pulsatil…
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In juvenile male monkeys, LH fell sharply after the initial rise despite continuous metastin 45-54 infusion.

    In plain wordsIn monkeys, LH dropped sharply after the first rise even though the infusion continued.

    Peptide
    Kisspeptin-10
    Outcome
    DecreaseLH decline during continued metastin 45-54 infusion
    Study

    rhesus monkey (Macaca mulatta)n = 3

    agonadal juvenile male monkeys primed with pulsatile GnRH
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    100 µg/h infusionAs given in this study (rhesus monkey (Macaca mulatta)).

    Source sentences

    Summary
    This rise was then followed by a precipitous drop in LH despite continuous exposure of GPR54 to metastin 45-54.
    1 context sentence
    Summary · context
    The effect of continuous administration of the C-terminal fragment of metastin, the ligand for the G protein-coupled receptor, GPR54, on GnRH-induced LH secretion was examined in three agonadal, juvenile male monkeys whose responsiveness to GnRH was heightened by pretreatment with a chronic pulsatil…
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In juvenile male monkeys on day 4 of continuous infusion, a metastin 45-54 bolus did not elicit an LH pulse, showing GPR54 desensitization.

    In plain wordsIn monkeys, after days of continuous metastin 45-54, a further dose no longer raised LH, which shows the receptor stopped responding.

    Peptide
    Kisspeptin-10
    Outcome
    No significant changeLH response to a metastin 45-54 bolus on day 4 of infusion
    Study

    rhesus monkey (Macaca mulatta)n = 3

    agonadal juvenile male monkeys primed with pulsatile GnRH
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    10 µg bolusAs given in this study (rhesus monkey (Macaca mulatta)).

    Source sentences

    Summary
    Although the NMDA and GnRH boluses were able to elicit LH pulses, that of hu metastin 45-54 was not, demonstrating functional integrity of GnRH neurons (NMDA) and GnRH receptors (NMDA and GnRH) but desensitization of GPR54.
    2 context sentences
    Summary · context
    On d 4, during the final 3 h of the infusion, single boluses of hu metastin 45-54 (10 microg), N-methyl-DL-aspartic acid (NMDA) (10 mg/kg) and GnRH (0.3 microg) were administered to interrogate each element of the metastin-GPR54-GnRH-GnRH receptor cascade.
    Summary · context
    The effect of continuous administration of the C-terminal fragment of metastin, the ligand for the G protein-coupled receptor, GPR54, on GnRH-induced LH secretion was examined in three agonadal, juvenile male monkeys whose responsiveness to GnRH was heightened by pretreatment with a chronic pulsatil…

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 09:43 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

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