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Study · In vitro (cells) · 2005

4 results

[Regenerative medicine of skeletal muscle].

Hara T, Nakayama Y, Nara N

Rinsho shinkeigaku = Clinical neurology1 Nov 2005Cited by 4 (Europe PMC)

PMID16447752 (opens in a new tab)PepBankPUB-16447752
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Efficacy outcome

    Thymosin beta4 stimulated migration of myoblasts.

    In plain wordsIn cells, thymosin beta4 increased the movement of muscle precursor cells.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseMyoblast migration
    Study

    n: not reported in source

    myoblasts
    Outcome group
    Muscle injury and repair · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    It stimulated migration and chemotaxis of myoblasts.
    1 context sentence
    Summary · context
    To identify these factors, we searched for mRNAs affected by the mdx mutation using cDNA microarrays with newly established skeletal muscle cell lines derived from mdx and normal mice.
  2. 02LabIn vitro (cells)Efficacy outcome

    Thymosin beta4 stimulated chemotaxis of myoblasts.

    In plain wordsIn cells, thymosin beta4 drew muscle precursor cells toward it.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseMyoblast chemotaxis
    Study

    n: not reported in source

    myoblasts
    Outcome group
    Muscle injury and repair · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    It stimulated migration and chemotaxis of myoblasts.
    1 context sentence
    Summary · context
    To identify these factors, we searched for mRNAs affected by the mdx mutation using cDNA microarrays with newly established skeletal muscle cell lines derived from mdx and normal mice.

Natural levels measured2

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 03AnimalEndogenous levelAnimal study (in vivo)Mechanism

    In mdx mice, the gene encoding thymosin beta4 was up-regulated in skeletal muscle.

    In plain wordsIn mdx mice, the body's own thymosin beta4 gene was more active in skeletal muscle.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseThymosin beta4 gene expression in skeletal muscle of mdx mice
    Study

    mousen: not reported in source

    mdx mice, model of Duchenne muscular dystrophy
    Comparator
    Normal mice
    Outcome group
    Muscle injury and repair · Musculoskeletal

    Source sentences

    Summary
    We found that genes encoding thymosin beta4, frizzled related protein 2 (FRP2), and regeneration-associated muscle protease (RAMP) are up-regulated in skeletal muscle of mdx mice.
    1 context sentence
    Summary · context
    To identify these factors, we searched for mRNAs affected by the mdx mutation using cDNA microarrays with newly established skeletal muscle cell lines derived from mdx and normal mice.

    This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.

  2. 04AnimalEndogenous levelAnimal study (in vivo)Mechanism

    Thymosin beta4 was induced in both regenerating muscle fibers and inflammatory cells after muscle injury.

    In plain wordsIn injured mouse muscle, the body's own thymosin beta4 rose in regenerating muscle fibers and inflammatory cells.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseThymosin beta4 induction after muscle injury
    Study

    mousen: not reported in source

    injured skeletal muscle
    Outcome group
    Muscle injury and repair · Musculoskeletal

    Source sentences

    Summary
    Thymosin beta4 was induced in both regenerating muscle fibers and inflammatory cells after muscle injury.
    1 context sentence
    Summary · context
    To identify these factors, we searched for mRNAs affected by the mdx mutation using cDNA microarrays with newly established skeletal muscle cell lines derived from mdx and normal mice.

    This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 01:52 UTC

    Study results updated

  2. Version 1

    12 Oct 2026, 18:17 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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