Thymosin beta4 is a determinant of the transformed phenotype and invasiveness of S-adenosylmethionine decarboxylase-transfected fibroblasts.

Nummela P, Yin M, Kielosto M, Leaner V, Birrer MJ, Hölttä E

Cancer research1 Jan 2006Cited by 25 (Europe PMC)

PMID16423999DOI10.1158/0008-5472.can-05-2421PepBankPUB-16423999

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

No result from this study comes from a test of the peptide.

Natural levels measured3

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

01LabEndogenous levelIn vitro (cells)Other
In AdoMetDC-transfected murine fibroblasts, up-regulation of Tbeta4 was the most prominent change in gene expression versus normal counterpart cells.
In plain wordsIn cells, the body's own Tbeta4 was strongly raised in transformed fibroblasts compared with normal cells.
Peptide
Thymosin beta-4 (human)
Outcome
IncreaseTbeta4 expression in AdoMetDC transformants
Study
mousen: not reported in source
AdoMetDC-transfected murine fibroblasts
Comparator
Normal counterpart cells
Outcome group
Tumor growth · Cancer
Source sentences
Summary
Up-regulation of the actin sequestering molecule thymosin beta4 was the most prominent change in both cell lines.
1 context sentence(design, population, supporting numbers)
Summary · context
Here, the gene expression profiles of these cells were compared with their normal counterpart by microarray analyses (Incyte Genomics, Palo Alto, CA, and Affymetrix, Santa Clara, CA).
This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-1642399901
02LabEndogenous levelIn vitro (cells)Mechanism
In AdoMetDC transformants, reversal of transformation by dominant-negative c-Jun (TAM67) reduced Tbeta4 mRNA.
In plain wordsIn cells, reversing transformation with a c-Jun mutant lowered the body's own Tbeta4 mRNA.
Peptide
Thymosin beta-4 (human)
Outcome
DecreaseTbeta4 mRNA after reversal of transformation by TAM67
Study
mousen: not reported in source
AdoMetDC-transfected murine fibroblasts
Outcome group
Tumor growth · Cancer
Source sentences
Summary
Further, reversal of transformation by dominant-negative mutant of c-Jun (TAM67) caused reduction in thymosin beta4 mRNA.
1 context sentence(design, population, supporting numbers)
Summary · context
Here, the gene expression profiles of these cells were compared with their normal counterpart by microarray analyses (Incyte Genomics, Palo Alto, CA, and Affymetrix, Santa Clara, CA).
This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-1642399903
03LabEndogenous levelIn vitro (cells)Other
Tbeta4 was up-regulated in ras-transformed fibroblasts and in metastatic human melanoma cells.
In plain wordsIn cells, the body's own Tbeta4 was raised in ras-transformed fibroblasts and metastatic melanoma cells.
Peptide
Thymosin beta-4 (human)
Outcome
IncreaseTbeta4 up-regulation in ras-transformed fibroblasts and melanoma cells
Study
n: not reported in source
ras-transformed fibroblasts and metastatic human melanoma cells
Outcome group
Tumor growth · Cancer
Source sentences
Summary
Up-regulation of thymosin beta4 was also found in ras-transformed fibroblasts and metastatic human melanoma cells.
1 context sentence(design, population, supporting numbers)
Summary · context
Here, the gene expression profiles of these cells were compared with their normal counterpart by microarray analyses (Incyte Genomics, Palo Alto, CA, and Affymetrix, Santa Clara, CA).
This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-1642399904

Studies that did not test the peptide alone1

In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Thymosin beta-4 (human).

04LabNot a test of Thymosin beta-4 (human) aloneIn vitro (cells)Mechanism
In AdoMetDC transformants, tetracycline-inducible Tbeta4 antisense RNA partially reversed the transformed phenotype.
In plain wordsIn cells, lowering Tbeta4 with antisense RNA partly reversed the transformed state of the fibroblasts.
Peptide
Thymosin beta-4 (human)
Outcome
DecreaseTransformed phenotype after Tbeta4 antisense RNA
Study
mousen: not reported in source
AdoMetDC-transfected murine fibroblasts
Outcome group
Tumor growth · Cancer
Source sentences
Summary
Tetracycline-inducible expression of thymosin beta4 antisense RNA caused a partial reversal of the transformed phenotype.
1 context sentence(design, population, supporting numbers)
Summary · context
Here, the gene expression profiles of these cells were compared with their normal counterpart by microarray analyses (Incyte Genomics, Palo Alto, CA, and Affymetrix, Santa Clara, CA).
In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).
Report a problemFND-1642399902

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
13 Oct 2026, 01:52 UTC
Study results updated
Version 1
12 Oct 2026, 18:17 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

MeSH terms

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