Skip to content

Study · In vitro (cells) · 2006

2 results

Quantitative analysis of MC1R gene expression in human skin cell cultures.

Roberts DW, Newton RA, Beaumont KA, Helen Leonard J, Sturm RA

Pigment cell research1 Feb 2006Cited by 70 (Europe PMC)

PMID16420249 (opens in a new tab)DOI10.1111/j.1600-0749.2005.00286.x (opens in a new tab)PepBankPUB-16420249
Publisher pagePubMedAsk about this study
Jump to 2 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Activity measurement

    In cultured human keratinocytes and fibroblasts, the MC1R agonist NDP-MSH did not elevate intracellular cAMP.

    In plain wordsIn cells, NDP-MSH did not raise cAMP in skin keratinocytes and fibroblasts.

    Peptide
    Melanotan I (afamelanotide)
    Outcome
    No significant changeIntracellular cAMP in keratinocytes and fibroblasts
    Study

    humann: not reported in source

    Cultured keratinocyte and fibroblast cells
    Outcome group
    Receptor activity and mechanism · Skin and wound
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Indeed, the MC1R agonist [NIe(4), D-Phe(7)] alpha-melanocyte stimulating hormone (NDP-MSH) was unable to elevate intracellular cyclic adenosine monophosphate (cAMP) levels in the keratinocyte and fibroblast cells examined, whereas a robust increase was elicited in melanocytes.
  2. 02LabIn vitro (cells)Activity measurement

    In cultured human melanocytes, the MC1R agonist NDP-MSH produced a robust increase in intracellular cAMP.

    In plain wordsIn cells, NDP-MSH clearly raised cAMP in melanocytes.

    Peptide
    Melanotan I (afamelanotide)
    Outcome
    IncreaseIntracellular cAMP in melanocytes
    Study

    humann: not reported in source

    Cultured melanocytes
    Outcome group
    Receptor activity and mechanism · Skin and wound
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Indeed, the MC1R agonist [NIe(4), D-Phe(7)] alpha-melanocyte stimulating hormone (NDP-MSH) was unable to elevate intracellular cyclic adenosine monophosphate (cAMP) levels in the keratinocyte and fibroblast cells examined, whereas a robust increase was elicited in melanocytes.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.