Melanocortin modulation of inflammatory cytokine and neuroendocrine responses to endotoxin in the monkey.

Vulliémoz NR, Xiao E, Xia-Zhang L, Ferin M, Wardlaw SL

Endocrinology12 Jan 2006Cited by 13 (Europe PMC)

PMID16410297DOI10.1210/en.2005-1430PepBankPUB-16410297

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In ovariectomized monkeys, NDP-MSH infusion decreased the TNF-alpha response to endotoxin by 61% (AUC).
In plain wordsIn monkeys, NDP-MSH lowered the TNF-alpha inflammation response to endotoxin compared with saline.
Peptide
Melanotan I (afamelanotide)
Outcome
DecreaseTNF-alpha response to endotoxin (AUC)
Study
monkeyn = 6
Ovariectomized monkeys with endotoxin challenge
Comparator
Saline
Outcome group
Inflammation markers · Immune and inflammation
Studied dose
Dose not stated · intravenous · 7 h infusionAs given in this study (monkey).
Measurements
AUC decrease
61%
TNF-alpha
Source sentences
Summary
The area under the response curve (AUC) decreased by 61% for TNF-alpha (P = 0.02)
1 context sentence(design, population, supporting numbers)
Summary · context
In the first study NDP-MSH or SHU9119 was infused iv for 7 h starting at 0800 h, endotoxin was injected at 1000 h, and serial blood samples were collected (n = 6).
Report a problemFND-1641029701
02AnimalAnimal study (in vivo)Efficacy outcome
In ovariectomized monkeys, NDP-MSH infusion decreased the IL-1beta response to endotoxin by 47% (AUC).
In plain wordsIn monkeys, NDP-MSH lowered the IL-1beta inflammation response to endotoxin compared with saline.
Peptide
Melanotan I (afamelanotide)
Outcome
DecreaseIL-1beta response to endotoxin (AUC)
Study
monkeyn = 6
Ovariectomized monkeys with endotoxin challenge
Comparator
Saline
Outcome group
Inflammation markers · Immune and inflammation
Studied dose
Dose not stated · intravenous · 7 h infusionAs given in this study (monkey).
Measurements
AUC decrease
47%
IL-1beta
Source sentences
Summary
47% for IL-1beta (P = 0.02), and 41% for IL-6 (P = 0.04); there was no effect on IL-1ra or IL-10.
1 context sentence(design, population, supporting numbers)
Summary · context
In the first study NDP-MSH or SHU9119 was infused iv for 7 h starting at 0800 h, endotoxin was injected at 1000 h, and serial blood samples were collected (n = 6).
Report a problemFND-1641029702
03AnimalAnimal study (in vivo)Efficacy outcome
In ovariectomized monkeys, NDP-MSH infusion decreased the IL-6 response to endotoxin by 41% (AUC).
In plain wordsIn monkeys, NDP-MSH lowered the IL-6 inflammation response to endotoxin compared with saline.
Peptide
Melanotan I (afamelanotide)
Outcome
DecreaseIL-6 response to endotoxin (AUC)
Study
monkeyn = 6
Ovariectomized monkeys with endotoxin challenge
Comparator
Saline
Outcome group
Inflammation markers · Immune and inflammation
Studied dose
Dose not stated · intravenous · 7 h infusionAs given in this study (monkey).
Measurements
AUC decrease
41%
IL-6
Source sentences
Summary
41% for IL-6 (P = 0.04); there was no effect on IL-1ra or IL-10.
1 context sentence(design, population, supporting numbers)
Summary · context
In the first study NDP-MSH or SHU9119 was infused iv for 7 h starting at 0800 h, endotoxin was injected at 1000 h, and serial blood samples were collected (n = 6).
Report a problemFND-1641029703
04AnimalAnimal study (in vivo)Efficacy outcome
In ovariectomized monkeys, NDP-MSH had no effect on the IL-1ra or IL-10 responses to endotoxin.
In plain wordsIn monkeys, NDP-MSH did not change the IL-1ra or IL-10 responses to endotoxin.
Peptide
Melanotan I (afamelanotide)
Outcome
No significant changeIL-1ra and IL-10 responses to endotoxin
Study
monkeyn = 6
Ovariectomized monkeys with endotoxin challenge
Comparator
Saline
Outcome group
Inflammation markers · Immune and inflammation
Studied dose
Dose not stated · intravenous · 7 h infusionAs given in this study (monkey).
Source sentences
Summary
there was no effect on IL-1ra or IL-10.
1 context sentence(design, population, supporting numbers)
Summary · context
In the first study NDP-MSH or SHU9119 was infused iv for 7 h starting at 0800 h, endotoxin was injected at 1000 h, and serial blood samples were collected (n = 6).
Report a problemFND-1641029704
05AnimalAnimal study (in vivo)Efficacy outcome
In ovariectomized monkeys, NDP-MSH attenuated the ACTH response to endotoxin.
In plain wordsIn monkeys, NDP-MSH lowered the ACTH stress hormone response to endotoxin compared with saline.
Peptide
Melanotan I (afamelanotide)
Outcome
DecreaseACTH response to endotoxin
Study
monkeyn = 6
Ovariectomized monkeys with endotoxin challenge
Comparator
Saline
Outcome group
Endogenous peptide levels · Endocrine and hormones
Studied dose
Dose not stated · intravenous · 7 h infusionAs given in this study (monkey).
Source sentences
Summary
NDP-MSH also attenuated ACTH (P < 0.001)
1 context sentence(design, population, supporting numbers)
Summary · context
In the first study NDP-MSH or SHU9119 was infused iv for 7 h starting at 0800 h, endotoxin was injected at 1000 h, and serial blood samples were collected (n = 6).
Report a problemFND-1641029705
06AnimalAnimal study (in vivo)Efficacy outcome
In ovariectomized monkeys, NDP-MSH attenuated the cortisol response to endotoxin.
In plain wordsIn monkeys, NDP-MSH lowered the cortisol response to endotoxin compared with saline.
Peptide
Melanotan I (afamelanotide)
Outcome
DecreaseCortisol response to endotoxin
Study
monkeyn = 6
Ovariectomized monkeys with endotoxin challenge
Comparator
Saline
Outcome group
Endogenous peptide levels · Endocrine and hormones
Studied dose
Dose not stated · intravenous · 7 h infusionAs given in this study (monkey).
Source sentences
Summary
NDP-MSH also attenuated ACTH (P < 0.001) and cortisol (P = 0.02) responses.
1 context sentence(design, population, supporting numbers)
Summary · context
In the first study NDP-MSH or SHU9119 was infused iv for 7 h starting at 0800 h, endotoxin was injected at 1000 h, and serial blood samples were collected (n = 6).
Report a problemFND-1641029706

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
13 Oct 2026, 21:44 UTC
Study results updated
Version 1
13 Oct 2026, 16:31 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

MeSH terms

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