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Study · Animal study (in vivo) · mouse · 2006

11 results

The influence of gastric pentadecapeptide BPC 157 on acute and chronic ethanol administration in mice. The effect of N(G)-nitro-L-arginine methyl ester and L-arginine.

Boban-Blagaic A, Blagaic V, Romic Z, Jelovac N, Dodig G, Rucman R, Petek M, Turkovic B, Seiwerth S, Sikiric P

Medical science monitor : international medical journal of experimental and clinical research19 Dec 2005Cited by 15 (Europe PMC)

PMID16369461 (opens in a new tab)PepBankPUB-16369461
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study11

6 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In mice with acute ethanol intoxication, BPC‑157 rapidly opposed sustained ethanol anesthesia.

    In plain wordsIn mice given alcohol, BPC‑157 quickly reduced the long-lasting anesthesia caused by ethanol.

    Peptide
    BPC-157
    Outcome
    DecreaseSustained ethanol anesthesia in acute intoxication
    Study

    mousen: not reported in source

    Acute ethanol intoxication
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    10 microg/kg · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    BPC 157 rapidly opposes the strongest disturbance presentations in acute intoxication (sustained ethanol anesthesia, complete loss of righting reflex, no reaction to external stimuli, hypothermia, 25% mortality) and withdrawal (prominent seizures).
    1 context sentence
    Summary · context
    Mice received intraperitoneally (i.p.) BPC 157 (10 microg/kg), L-NAME (10 mg/kg), and L-arginine (400 mg/kg), alone or in combination, 5 minutes before or after acute ethanol (4 g/kg i.p.) intoxication or after 0, 3, or 7 hours of withdrawal after drinking 20% alcohol for 13 days.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In mice with acute ethanol intoxication, BPC‑157 rapidly opposed the complete loss of righting reflex.

    In plain wordsIn mice given alcohol, BPC‑157 quickly counteracted the loss of the reflex to turn upright.

    Peptide
    BPC-157
    Outcome
    DecreaseLoss of righting reflex in acute intoxication
    Study

    mousen: not reported in source

    Acute ethanol intoxication
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    10 microg/kg · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    BPC 157 rapidly opposes the strongest disturbance presentations in acute intoxication (sustained ethanol anesthesia, complete loss of righting reflex, no reaction to external stimuli, hypothermia, 25% mortality) and withdrawal (prominent seizures).
    1 context sentence
    Summary · context
    Mice received intraperitoneally (i.p.) BPC 157 (10 microg/kg), L-NAME (10 mg/kg), and L-arginine (400 mg/kg), alone or in combination, 5 minutes before or after acute ethanol (4 g/kg i.p.) intoxication or after 0, 3, or 7 hours of withdrawal after drinking 20% alcohol for 13 days.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In mice with acute ethanol intoxication, BPC‑157 rapidly opposed the lack of reaction to external stimuli.

    In plain wordsIn mice given alcohol, BPC‑157 quickly counteracted the lack of response to outside stimuli.

    Peptide
    BPC-157
    Outcome
    DecreaseReaction to external stimuli in acute intoxication
    Study

    mousen: not reported in source

    Acute ethanol intoxication
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    10 microg/kg · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    BPC 157 rapidly opposes the strongest disturbance presentations in acute intoxication (sustained ethanol anesthesia, complete loss of righting reflex, no reaction to external stimuli, hypothermia, 25% mortality) and withdrawal (prominent seizures).
    1 context sentence
    Summary · context
    Mice received intraperitoneally (i.p.) BPC 157 (10 microg/kg), L-NAME (10 mg/kg), and L-arginine (400 mg/kg), alone or in combination, 5 minutes before or after acute ethanol (4 g/kg i.p.) intoxication or after 0, 3, or 7 hours of withdrawal after drinking 20% alcohol for 13 days.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In mice with acute ethanol intoxication, BPC‑157 rapidly opposed hypothermia.

    In plain wordsIn mice given alcohol, BPC‑157 quickly counteracted the drop in body temperature.

    Peptide
    BPC-157
    Outcome
    DecreaseHypothermia in acute intoxication
    Study

    mousen: not reported in source

    Acute ethanol intoxication
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    10 microg/kg · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    BPC 157 rapidly opposes the strongest disturbance presentations in acute intoxication (sustained ethanol anesthesia, complete loss of righting reflex, no reaction to external stimuli, hypothermia, 25% mortality) and withdrawal (prominent seizures).
    1 context sentence
    Summary · context
    Mice received intraperitoneally (i.p.) BPC 157 (10 microg/kg), L-NAME (10 mg/kg), and L-arginine (400 mg/kg), alone or in combination, 5 minutes before or after acute ethanol (4 g/kg i.p.) intoxication or after 0, 3, or 7 hours of withdrawal after drinking 20% alcohol for 13 days.
  5. 05AnimalAnimal study (in vivo)Safety outcome

    In mice with acute ethanol intoxication, BPC‑157 rapidly opposed the 25% mortality of intoxication.

    In plain wordsIn mice given alcohol, BPC‑157 quickly counteracted the deaths caused by intoxication.

    Peptide
    BPC-157
    Outcome
    DecreaseMortality in acute intoxication
    Study

    mousen: not reported in source

    Acute ethanol intoxication
    Outcome group
    Mortality · Whole body
    Studied dose
    10 microg/kg · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    BPC 157 rapidly opposes the strongest disturbance presentations in acute intoxication (sustained ethanol anesthesia, complete loss of righting reflex, no reaction to external stimuli, hypothermia, 25% mortality) and withdrawal (prominent seizures).
    1 context sentence
    Summary · context
    Mice received intraperitoneally (i.p.) BPC 157 (10 microg/kg), L-NAME (10 mg/kg), and L-arginine (400 mg/kg), alone or in combination, 5 minutes before or after acute ethanol (4 g/kg i.p.) intoxication or after 0, 3, or 7 hours of withdrawal after drinking 20% alcohol for 13 days.
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In mice in ethanol withdrawal, BPC‑157 rapidly opposed prominent seizures.

    In plain wordsIn mice withdrawing from alcohol, BPC‑157 quickly counteracted strong seizures.

    Peptide
    BPC-157
    Outcome
    DecreaseSeizures in alcohol withdrawal
    Study

    mousen: not reported in source

    Ethanol withdrawal after drinking 20% alcohol for 13 days
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    10 microg/kg · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    BPC 157 rapidly opposes the strongest disturbance presentations in acute intoxication (sustained ethanol anesthesia, complete loss of righting reflex, no reaction to external stimuli, hypothermia, 25% mortality) and withdrawal (prominent seizures).
    2 context sentences
    Summary · context
    after 0, 3, or 7 hours of withdrawal after drinking 20% alcohol for 13 days.
    Summary · context
    Mice received intraperitoneally (i.p.) BPC 157 (10 microg/kg), L-NAME (10 mg/kg), and L-arginine (400 mg/kg), alone or in combination, 5 minutes before or after acute ethanol (4 g/kg i.p.) intoxication or after 0, 3, or 7 hours of withdrawal after drinking 20% alcohol for 13 days.

Studies that did not test the peptide alone5

In this study, BPC-157 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking BPC-157.

  1. 07AnimalNot a test of BPC-157 aloneAnimal study (in vivo)Efficacy outcome

    In mice with acute ethanol intoxication, BPC157 combined with L-NAME followed the presentation of L-NAME alone.

    In plain wordsIn mice given alcohol, BPC‑157 plus L-NAME looked like L-NAME alone, which aggravates intoxication.

    Peptide
    BPC-157
    Outcome
    Not applicableBPC 157 plus L-NAME in acute intoxication
    Study

    mousen: not reported in source

    Acute ethanol intoxication
    Outcome group
    Neuroprotection · Nervous system and cognition

    Source sentences

    Summary
    BPC157+NO-agent: In acute intoxication (L-NAME predominating in NO-system functioning to aggravate intoxication), both BPC157+L-NAME and BPC157+L-arginine follow the presentation of L-NAME, but without worsened mortality.
    1 context sentence
    Summary · context
    Mice received intraperitoneally (i.p.) BPC 157 (10 microg/kg), L-NAME (10 mg/kg), and L-arginine (400 mg/kg), alone or in combination, 5 minutes before or after acute ethanol (4 g/kg i.p.) intoxication or after 0, 3, or 7 hours of withdrawal after drinking 20% alcohol for 13 days.

    In this study, BPC-157 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking BPC-157.

  2. 08AnimalNot a test of BPC-157 aloneAnimal study (in vivo)Efficacy outcome

    In mice with acute ethanol intoxication, BPC157 combined with L-arginine followed the presentation of L-NAME.

    In plain wordsIn mice given alcohol, BPC‑157 plus L-arginine looked like L-NAME alone, which aggravates intoxication.

    Peptide
    BPC-157
    Outcome
    Not applicableBPC 157 plus L-arginine in acute intoxication
    Study

    mousen: not reported in source

    Acute ethanol intoxication
    Outcome group
    Neuroprotection · Nervous system and cognition

    Source sentences

    Summary
    BPC157+NO-agent: In acute intoxication (L-NAME predominating in NO-system functioning to aggravate intoxication), both BPC157+L-NAME and BPC157+L-arginine follow the presentation of L-NAME, but without worsened mortality.
    1 context sentence
    Summary · context
    Mice received intraperitoneally (i.p.) BPC 157 (10 microg/kg), L-NAME (10 mg/kg), and L-arginine (400 mg/kg), alone or in combination, 5 minutes before or after acute ethanol (4 g/kg i.p.) intoxication or after 0, 3, or 7 hours of withdrawal after drinking 20% alcohol for 13 days.

    In this study, BPC-157 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking BPC-157.

  3. 09AnimalNot a test of BPC-157 aloneAnimal study (in vivo)Safety outcome

    In mice with acute ethanol intoxication, BPC157 combined with L-NAME or L-arginine did not worsen mortality.

    In plain wordsIn mice given alcohol, BPC‑157 plus L-NAME or L-arginine did not make deaths more likely.

    Peptide
    BPC-157
    Outcome
    No significant changeMortality with BPC 157 plus NO-agent in acute intoxication
    Study

    mousen: not reported in source

    Acute ethanol intoxication
    Outcome group
    Mortality · Whole body

    Source sentences

    Summary
    BPC157+NO-agent: In acute intoxication (L-NAME predominating in NO-system functioning to aggravate intoxication), both BPC157+L-NAME and BPC157+L-arginine follow the presentation of L-NAME, but without worsened mortality.
    1 context sentence
    Summary · context
    Mice received intraperitoneally (i.p.) BPC 157 (10 microg/kg), L-NAME (10 mg/kg), and L-arginine (400 mg/kg), alone or in combination, 5 minutes before or after acute ethanol (4 g/kg i.p.) intoxication or after 0, 3, or 7 hours of withdrawal after drinking 20% alcohol for 13 days.

    In this study, BPC-157 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking BPC-157.

  4. 10AnimalNot a test of BPC-157 aloneAnimal study (in vivo)Efficacy outcome

    In mice in ethanol withdrawal, BPC157 combined with L-NAME followed the presentation of L-NAME.

    In plain wordsIn mice withdrawing from alcohol, BPC‑157 plus L-NAME looked like L-NAME alone.

    Peptide
    BPC-157
    Outcome
    Not applicableBPC 157 plus L-NAME in withdrawal
    Study

    mousen: not reported in source

    Ethanol withdrawal after drinking 20% alcohol for 13 days
    Outcome group
    Neuroprotection · Nervous system and cognition

    Source sentences

    Summary
    In withdrawal (L-arginine predominating in NO-system functioning to oppose disturbance symptoms), BPC157+L-NAME follows the presentation of L-NAME, while BPC 157+L-arginine imitates that of L-arginine.
    1 context sentence
    Summary · context
    Mice received intraperitoneally (i.p.) BPC 157 (10 microg/kg), L-NAME (10 mg/kg), and L-arginine (400 mg/kg), alone or in combination, 5 minutes before or after acute ethanol (4 g/kg i.p.) intoxication or after 0, 3, or 7 hours of withdrawal after drinking 20% alcohol for 13 days.

    In this study, BPC-157 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking BPC-157.

  5. 11AnimalNot a test of BPC-157 aloneAnimal study (in vivo)Efficacy outcome

    In mice in ethanol withdrawal, BPC‑157 combined with L-arginine imitated the presentation of L-arginine.

    In plain wordsIn mice withdrawing from alcohol, BPC‑157 plus L-arginine looked like L-arginine alone, which opposes withdrawal symptoms.

    Peptide
    BPC-157
    Outcome
    Not applicableBPC 157 plus L-arginine in withdrawal
    Study

    mousen: not reported in source

    Ethanol withdrawal after drinking 20% alcohol for 13 days
    Outcome group
    Neuroprotection · Nervous system and cognition

    Source sentences

    Summary
    In withdrawal (L-arginine predominating in NO-system functioning to oppose disturbance symptoms), BPC157+L-NAME follows the presentation of L-NAME, while BPC 157+L-arginine imitates that of L-arginine.
    1 context sentence
    Summary · context
    Mice received intraperitoneally (i.p.) BPC 157 (10 microg/kg), L-NAME (10 mg/kg), and L-arginine (400 mg/kg), alone or in combination, 5 minutes before or after acute ethanol (4 g/kg i.p.) intoxication or after 0, 3, or 7 hours of withdrawal after drinking 20% alcohol for 13 days.

    In this study, BPC-157 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking BPC-157.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    10 Oct 2026, 08:19 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 02:56 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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