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Study · Measured the body's own peptide · 2006

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Surfactant sodium lauryl sulfate enhances skin vaccination: molecular characterization via a novel technique using ultrafiltration capillaries and mass spectrometric proteomics.

Huang CM, Wang CC, Kawai M, Barnes S, Elmets CA

Molecular & cellular proteomics : MCP28 Nov 2005Cited by 30 (Europe PMC)

PMID16316979 (opens in a new tab)DOI10.1074/mcp.m500259-mcp200 (opens in a new tab)PepBankPUB-16316979
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Summary

The skin is a highly accessible organ and thus provides an attractive immune environment for cost-effective, simple, and needle-free delivery of vaccines and immunomodulators. In this study, we pretreated mouse skin with an anionic surfactant, sodium lauryl sulfate (SLS), for a short period of time (10 min) followed by epicutaneous vaccination with hen egg lysozyme antigen. We demonstrated for the first time that pretreatment of skin with surfactant SLS significantly enhances the production of antibody to hen egg lysozyme. Short term pretreatment with SLS disorganized the stratum corneum, extracted partial lamellar lipids, induced the maturation of Langerhans cells, and did not result in epidermis thickening. To reveal the mechanism underlying these changes, particularly at the molecular level, we used a novel proteomic technique using ultrafiltration capillaries and mass spectrometry to identify in vivo proteins/peptides secreted in the SLS-pretreated skin. Two secretory proteins, named as calcium-binding protein S100A9 and thymosin beta4, were identified by this novel technique. These two proteins thus may provide new insight into the enhancing effect of surfactants on skin vaccination.
CC BYText from Europe PMC. Highlighted sentences are the source of results.

Results from this study1

No result from this study comes from a test of the peptide.

Natural levels measured1

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01AnimalEndogenous levelAnimal study (in vivo)Other

    In mouse skin pretreated with sodium lauryl sulfate, ultrafiltration proteomics identified the body's own thymosin beta4 as one of two secreted proteins.

    In plain wordsIn mice, the body's own thymosin beta4 was found among proteins secreted in skin pretreated with a surfactant.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    Not applicableThymosin beta4 identified among proteins secreted in SLS-pretreated skin
    Study

    mousen: not reported in source

    SLS-pretreated mouse skin
    Outcome group
    Immune response · Skin and wound

    Source sentences

    Summary
    Two secretory proteins, named as calcium-binding protein S100A9 and thymosin beta4, were identified by this novel technique.
    1 context sentence
    Summary · context
    In this study, we pretreated mouse skin with an anionic surfactant, sodium lauryl sulfate (SLS), for a short period of time (10 min) followed by epicutaneous vaccination with hen egg lysozyme antigen.

    This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 01:52 UTC

    Study results updated

  2. Version 1

    12 Oct 2026, 18:17 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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